āAngiosil Retardā is a drug from the category of antihypoxants, which helps to improve the processing of oxygen passing through the body, as well as increase resistance to hypoxia. The drug has a direct effect on neural connections in the brain and cardiomyocytes, leading to an optimal state of their metabolic process and functioning.
Structure
"Angiosil Retard" is made in the form of biconvex round tablets, coated with a gastro-soluble pink coating. The drug is packaged in packages of 10 or 14 tablets.
The active component of the drug is trimetazidine dihydrochloride, the concentration of which in one tablet is 35 mg. In addition, the composition of the tablets is supplemented by auxiliary components:
- Iron oxide is red and yellow.
- Colloidal silicon dioxide.
- Macrogol.
- Microcrystalline cellulose.
- Polydextrose.
- Hypromellose.
- Lactose Monohydrate.
- Titanium dioxide.
- Magnesium stearate.
The release form of the drug is only tablet. The cost of āAngiosil Retardā is on average 400 rubles.
The properties
The medication helps to improve the metabolism in the myocardium, as well as neurosensitive connections, broken by coronary heart disease. The drug has a number of therapeutic properties, including antihypoxic and antianginal. The direct effect is the active component of the drug on brain neurons and cardiomyocytes, which helps to optimize metabolism.
This confirms the instructions for use for Angiosil Retard.
The cytoprotective effect of the drug is explained by an increase in the energy potential, activation of decarboxylation of the oxidative process and optimization of oxygen consumption, characterized by an increase in the intensity of aerobic glycolysis and the installation of a blockade on the oxidation of fatty acids. Angiosil Retard maintains an optimal level of myocardial contractions and prevents a decrease in ATP and phosphocreatine levels at the intracellular level.
With an increase in acidity in the body, called acidosis, the drug normalizes the work of the membrane channels of ions and prevents the accumulation of sodium and calcium in cardiomyocytes. In addition, the active component normalizes the content of potassium ions inside the cell. The drug reduces the intensity of acidosis within the cell and reduces the content of phosphates, which provoke myocardial ischemia and reperfusion.
āAngiosil Retardā suspends the pathogenic effects of free radicals, helps preserve the integrity of the cell membrane and prevents the activation of neutrophils in the ischemic region. The drug increases the duration of the electric potential and reduces the release of creatine phosphokinase from the cells and the severity of myocardial damage due to ischemia.
In the treatment of angina pectoris, the drug reduces the number of seizures against a background of reduced nitrate intake. After two weeks of therapy, there is an increase in resistance to physical activity, blood pressure decreases. When using the drug, the hearing of patients improves markedly, dizziness and tinnitus decrease, vestibular tests show results close to normal.
In the treatment of vascular eye pathologies, taking the medication helps to restore the retina.
Indications
In accordance with the instructions for use, āAngiosil Retardā is prescribed for the treatment of the following pathologies:
- Cochleovestibular disorders provoked by coronary artery disease. Such disorders are characterized by impaired auditory perception, tinnitus and dizziness.
- Disorders of the vascular system of the chorioretinal type. They are caused by an inflammatory process that negatively affects the well-being of a person.
- In the treatment of angina pectoris, the drug is included in the therapeutic regimen along with other drugs.
Contraindications
There are a number of restrictions for receiving funds. The drug is contraindicated for use in the following cases:
- Hypersensitivity to the components included in the composition of the drug, including auxiliary.
- Pathology of the liver.
- Kidney failure.
- Lactose intolerance.
- Children under the age of eighteen.
- The period of gestation and breastfeeding.
According to studies, the drug has a teratogenic effect on the fetus, which explains the ban on its use during pregnancy and breastfeeding.
Instruction manual
According to the instructions for the use of the drug āAngias Relardā, it is prescribed according to the standard scheme, which involves taking 1 tablet in the morning and evening, with meals. The duration of the therapeutic course is determined by the doctor, based on the patient's condition and the diagnosis.
Adverse reactions
Occasionally, patients experience adverse reactions to the reception of āAnguil Retardā. Most often, patients complain of the following symptoms:
- Headache and dizziness.
- Dyspeptic disorders.
- Nausea and vomiting.
- Soreness in the abdomen.
- An allergic reaction, accompanied by a rash and itching.
- Hypotension of the orthostatic type.
In addition, it should be borne in mind that the active component of the drug is capable of influencing the speed of psychomotor reactions, therefore it is not recommended to drive vehicles or perform work requiring increased concentration of attention on the background of taking Anguzil Retard tablets.
Data on overdose is currently not available, since such cases have not been reported.
Special recommendations
The price will be presented below. Trimetazidine is not intended to eliminate exacerbation of angina pectoris, as well as against the background of a progressive heart attack. In these situations, it is recommended to adjust the treatment regimen and review the prescribed dosages.
āAngiosil Retardā is not recommended at the initial stage of therapy for myocardial infarction, as well as to eliminate unstable angina.
There are no data on the use of the drug against the background of severe dysfunctional liver lesions, therefore, the appointment of antihypoxants is contraindicated in patients with similar pathologies.
The tool affects the concentration of attention and the speed of the psychomotor functions of the body. And although this effect is insignificant, it is not recommended to engage in work requiring increased concentration, against the background of drug treatment.
Reviews
āAngiosil Retardā is considered a highly effective drug intended for the treatment of coronary heart disease. Numerous positive reviews indicate its effectiveness.
Patients who have undergone a course of therapy with the drug, note its property to effectively and quickly eliminate angina attacks and normalize blood pressure. Some reviews contain information about adverse reactions to taking the drug, namely lethargy and weakness, which really do not allow you to drive a car during treatment. However, there are quite few such reviews, which indicates the relative safety of the āAngiosil Retardā. Another area of āāapplication of the drug, which found many positive responses among patients, is the elimination of auditory perception disorders that arose against the background of diseases of ENT organs.
Specialists also give a rather high rating to āAangzhyil Retardā. They often prescribe the drug to patients with coronary heart disease, accompanied by heart rhythm disturbance. At the same time, doctors note a noticeable decrease in gastric extrasystoles, as well as a decrease in the number of paroxysmal type tachycardia attacks localized in the supraventricular region.
Price
This drug can be purchased for 350-400 rubles. It depends on the region and the pharmacy network.
Analogues of āAnsangil Retardā
A number of drugs are identified that have a similar effect, as well as an identical composition. Among the most popular drug substitutes are the following:
- "Trimektal."
- "Rimekor."
- The Triducard.
- "Deprenorm."
- "Metagard."
- Carditrim.
- "Antisten" and others.
One cannot fail to mention Trimetazidine. The price of this tool is much lower than the original - 100-130 rubles.
The selection of an analogue should be carried out in agreement with the attending physician, since each drug has its own characteristics of taking and contraindications. It is impossible to prescribe any of the listed drugs on your own, as this can cause the development of undesirable consequences for the body and the deterioration of the patient's condition.