There are many medications based on bisoprolol that are successfully used to treat high blood pressure and heart muscle failure. Among them, the domestic drug Bisoprolol-Prana is distinguished.
Characteristic
Such selective beta-blocking agent is produced by the Russian company LLC PRANAFARM.
Available in the form of round, biconvex tablets, which have a separation and coating in the form of a film shell.
When using Bisoprolol-Prana, the instructions for use are the first thing you need to pay attention to. The drug is available in the following dosages: 5 and 10 mg. The color of the shell of the smaller tablets is light yellow, and the large ones are light orange. The contents of the medication is almost white.
Structure
One tablet of Bisoprolol-Prana medicine contains 5 and 10 mg of bisoprolol hemifumarate as an active substance. The presence of magnesium stearate, corn starch, microcrystalline cellulose, crospovidone, colloidal silicon oxide, calcium dehydrated hydrogen phosphate allows you to form a medication and provide the necessary solubility and bioavailability.
In the film coating of a dosage of 5 mg, yellow iron oxide, polyethylene glycol (grade 400), titanium dioxide, and silicone are present. In the coating that envelops the large pill, there is another coloring material in the form of red iron oxide.
Mechanism of action
To the selective beta-adrenergic blocking agents that do not have their own activity of sympathomimetic type, include “Bisoprolol-Prana”. Instructions for use describe its pharmacodynamic features. Tablets have an effect on reducing pressure, normalizing rhythm and eliminating myocardial muscle ischemia. When low-dose blocking of the heart-beta-1-adrenergic receptor drug is blocked, the production of cyclic adenosine monophosphate and the flow of calcium ions inside the cells decrease. Also, a decrease in the reduction in heart rate and its frequency is observed, the processes associated with conduction and excitability are inhibited.
Antihypertensive effect is manifested when the value that determines the minute volume of blood circulation is underestimated, and the effect on the peripheral vascular bed is reduced. A decrease in high pressure occurs after a few days, and to stabilize the action, a two-month treatment is necessary.
The antiarrhythmic effect is manifested in the elimination of causes that violate the heartbeat. These include the state of tachycardia, increased activity of the nervous system in the sympathetic department, an increased content of cyclic adenosine monophosphate, and arterial hypertension.
Indications for use
Before use, it is necessary to study for which groups of patients Bisoprolol-Prana is intended. Indications for use are associated with antianginal effect. It is due to the lower need for cardiac myocardium in oxygen molecules due to a decrease in the frequency of contractions, an increase in blood supply and time during diastole.
What is the effect of a drug such as Bisoprolol-Prana tablets? What are they taken from? Given the pharmacotherapeutic characteristics, they are used for:
- arterial hypertension therapy;
- coronary heart disease;
- angina with tension;
- for the prevention of secondary myocardial infarction:
- chronic deficiency.
Here are the main groups for which the use of the drug "Bisoprolol-Prana" is desirable. Indications for use are associated with impaired cardiac function. This includes a sinus rhythm increase, supraventricular and ventricular extrasystole, a change in heartbeat when the mitral valve protrudes and hyperthyroidism.
The specifics of using the drug
Instructions for use "Bisoprolol-Prana" recommends taking the medicine in the morning before breakfast, completely without chewing.
For the treatment of hypertension, cardiac ischemia and prevention of angina pectoris , a single dose of a smaller dose of tablets, including 5 mg of bisoprolol, is used. If necessary, the dosage is doubled, but it is also used once. The maximum amount of bisoprolol should not exceed a daily dose of 20 mg.
Only the attending physician can prescribe the dosage and time of taking Bisoprolol-Prana. Indications must comply with the instructions of the drug. Before the appointment, check the frequency of contractions of the heart muscle. Possible adjustment of the number of tablets after studying the therapeutic response.
Many patients are wondering if Bisoprolol-Prana can be halved. The presence of a separator makes it possible to reduce the tablet if a different dosage is needed.
To eliminate chronic heart failure, the first week using 1.25 mg of bisoprolol. Such a dose can be obtained by dividing a tablet with an active substance content of 2.5 mg. However, it will be necessary to begin therapy with a drug from another manufacturer, since Bisoprolol-Prana is available only in 5 and 10 mg. During the second week, 2.5 mg are prescribed. From the 14th day of treatment, 3.75 mg of the drug is taken. In the fourth week, the dosage is increased to 5 mg, and after two months of therapy, 7.5 mg of bisoprolol is used. The twelfth week begins with a dose of 10 mg.
If the patient has various disorders in the functioning of the kidneys or liver, and the creatinine clearance values are less than 20 ml per 1 minute, then no more than 10 mg of the drug can be prescribed.
During a scheduled operation, bisoprolol is canceled in two days so that it does not affect anesthesia. If a tablet has been drunk, then such an anesthetic is selected that exhibits an inotropic effect, negative in the minimum size.
When an elderly patient has an attack of bradycardia with a heart rate of less than 52 beats per minute, arterial hypotension with systolic pressure of less than 100 millimeters of mercury, bronchospasm, ventricular arrhythmia, hepatic and renal work is disrupted, then the dosage is reduced, until the therapy is completely discontinued. The exclusion of bisoprolol can cause the development of a depressive state, which is caused by this beta-blocker.
Elderly do not carry out dosage adjustment.
A sharp interruption of treatment is not allowed, which can cause the development of a severe form of arrhythmia or myocardial muscle infarction. The drug is canceled due to a smooth dose reduction over 14 days. For three days, a dosage reduction of 25% is allowed.
Treatment features
For the use of Bisoprolol-Prana, the instructions for use include a list of measures that monitor the condition of a sick person. These include determining the frequency of heart contractions and measuring blood pressure daily in the initial stages, which are then checked after three months. Other important indicators are the electrocardiogram and sugar level in diabetics, which are measured no more often than after 5 months.
Elderly patients need periodic monitoring of the kidneys, which is carried out after 4 months.
Therapy of chronic heart failure at the initial stage of taking a small dose requires a four-hour examination of the patient, in which the frequency of myocardial contraction, blood pressure are checked and an electrocardiogram is done.
Before prescribing treatment with bisoprolol, the patient is taught how to calculate heart rate. In the case of low values of this indicator (up to 50 beats per minute), medical consultation is required.
Also describing the effect of the drug “Bisoprolol-Prana”, the instruction includes information on the need for studies that determine external respiration for patients with bronchopulmonary diseases.
Beta-blocking drugs do not help all patients with angina pectoris. Their inefficiency is due to the presence of severe coronary atherosclerosis, which has a low ischemic threshold. In this condition, the heart rate will be less than 100 beats per minute, and there is also an increase in the end-diastolic volume in the left ventricle with a violation of subendocardial blood flow. Bisoprolol also helps smokers worse.
People with bronchospastic disorders are prescribed such a cardioselective if there is intolerance and low effectiveness of drugs that reduce blood pressure. With an overdose, there is a high probability of bronchial spasm.
If patients with thyrotoxicosis beta-blocker are treated, then it is possible to mask individual clinical signs of excessive thyroid function, primarily tachycardia. Such patients can not abruptly discontinue the drug, in order to avoid increasing symptoms.
If patients wear contact lenses, then taking bisoprolol can cause a decrease in the production of tear fluid, which requires additional instillation of the eyes with special drops.
When the drug is used by patients with pheochromocytoma, paradoxical arterial hypertension is possible. In this case, a preliminary alpha-adrenergic blocking action is necessary.
The presence of diabetes masks the attacks of tachycardia caused by a decrease in blood glucose levels. Being a selective beta-blocker, the drug is not able to enhance the insulin hypoglycemic state and inhibit the normalization of glucose levels to the desired values.
Catecholamines, normetanephrine, antinuclear antibodies, and vanillyl mindic acid in blood and urine are determined only with the exception of Bisoprolol-Prana.
For pregnant and lactating women, the prescription of the drug is carried out, taking into account the benefits for the mother's body, however, there is the likelihood of undesirable consequences in the embryo.
Who is contraindicated for treatment?
Bisoprolol-Prana tablets are not recommended for use in patients with increased susceptibility, acute or chronic form of decompensated heart muscle failure, cardiogenic shock, sinoauricular and atrioventricular blockade of the second and third types, with a syndrome associated with weakness in the sinus node, slow heart rate with an intensity of less than 60 strokes.
Contraindication is the presence of:
- cardiomegaly with increasing size and weight of the heart muscle;
- low pressure in arteries with a systolic value of less than 90 millimeters of mercury;
- chronic obstructive pulmonary disease;
- bronchial asthma;
- circulatory disorders in the peripheral vessels in the late stages.
Undesirable consequences
The medicine “Bisoprolol-Prana” can provoke various side effects that affect the central and peripheral zones of the nervous system. They are manifested by headache, fatigue, disturbance of sleep patterns, depression and hallucinations.
Undesirable processes in the heart and blood vessels are caused by orthostatic hypotension, hot flashes, sweating, slow heartbeat and myocardial insufficiency.
Other side effects include decreased secretion of the lacrimal gland, the development of conjunctivitis, diarrhea, itching on the skin, constipation, nausea, muscle weakness, and seizures. Obstructive symptoms may appear in the bronchi.
Similar preparts
The original bisoprolol-based agent is Concor tablets. They are produced by the German company Merck.
Based on this medication, similar preparations were developed containing bisoprolol fumarate as an active component.
Russian drug manufacturers produce beta-blockers with different brand names. An example is Bisoprolol-Prana: its analogues have a dosage of 2.5 mg, 5 mg and 10 mg. These medicines include tablets:
- "Bisogamma";
- "Niperten";
- Cordinorm;
- Biprol.
Similar funds are also produced by foreign companies. There are drugs on the pharmaceutical market whose name contains the name of the company, for example, Bisoprolol-Teva, Bisoprolol-Ratiopharm, Bisoprolol-Sandoz, Bisoprolol-Lugal.
There are analogues that are simply called "Bisoprolol." Such medicines are produced by Russian factories: Verteks CJSC, Severnaya Zvezda CJSC, Ozon Pharmaceuticals LLC, Biocom CJSC.
If we compare the tablets "Bisoprolol" and "Bisoprolol-Prana", the difference will be in the qualitative and quantitative composition of auxiliary components. Such discrepancies do not affect the bioavailability and permeability of the active substance in the body, which means that the therapeutic effect of the drug will be the same.
Reviews
Many patients note the convenience of using medications containing bisoprolol, because they are taken only once a day. One tablet is enough for the whole day to normalize blood pressure.
About the tool "Bisoprolol-Prana" reviews are good. They testify to its high selectivity, which is why taking tablets is accompanied by fewer undesirable effects compared to other beta-blockers.
Patients note the ease of use and rare side effects that contribute to the transition of some patients to treatment with this drug.
Men claim that taking the drug does not cause a violation of potency. In addition, this fact has been proven through numerous studies.
The drug “Bisoprolol-Prana” exhibits metabolic neutrality with respect to cholesterol, triglyceride and glucose metabolism. This property allows you to prescribe it to patients with a second type of diabetes mellitus or a predisposition to increase glucose levels in the blood. Accordingly, such patients also leave positive reviews about the drug.
Due to the small number of adverse reactions, tablets are prescribed for patients in old age. Patients claim that the drug is more effective and safer than other antihypertensive drugs of the beta-blocker series.
The advantage of the Bisoprolol-Prana medication is its low price, which is quite affordable for low-income people, which is also reflected in grateful reviews.
But despite all the advantages of pills, only a doctor can prescribe them based on the results of the examination.