Acne (or, in other words, acne) is an inflammatory disease of the skin that is caused by changes in pilosebial structures.
The causes of this disease are still unknown. The main role in the mechanism of their development is played by seborrhea, which reduces the bactericidal effect of fat and leads to the reproduction of coccal flora.
Today, there are many different drugs that effectively treat acne. One of them is the drug "Duak" (gel). The price, reviews about the external agent and the method of its use are presented below.
Form, packaging, composition
Gel "Duak" is on sale in tubes of 15 g. It contains such active ingredients as benzoyl peroxide and clindamycin. In addition, an external agent includes carbomer, disodium lauryl sulfosuccinate, dimethicone, glycerin, disodium edetate, colloidal aqueous silicon dioxide, sodium hydroxide, poloxamer, and purified water.
Pharmacological features
Duac Gel is an external treatment used to treat acne. Its effectiveness is completely due to the composition.
Clindamycin is a lincosamide antibiotic. It has a bacteriostatic effect against a wide range of anaerobic microorganisms and gram-positive aerobic bacteria.
By binding to the 23S subunit of the ribosome (bacterial), lincosamides, or rather clindamycin, inhibits the early stages of protein synthesis. This component has a predominantly bacteriostatic effect. Although its high concentrations against sensitive microorganisms can also have a bactericidal effect.
Clindamycin activity has been clinically proven during the treatment of comedones in people with acne. After using this substance, the percentage of free fatty acids located on the surface of the skin decreased from 14 to 1.
What other properties are inherent in the drug "Duak"? The gel, the price of which is indicated below, contains a component such as benzoyl peroxide. It has a keratolytic effect (very mild) against comedones at any stage of their development.
This substance is oxidizing. It has bactericidal activity against Propionibacteium acnes, which is the cause of acne vulgaris. Also, this component is a sebostatic agent. It counteracts the excessive production of sebum that is associated with acne.
Adding this ingredient to Duac gel significantly reduces the potential for clindamycin-resistant microorganisms.
Kinetic properties
Is the drug “Duak” (gel) absorbed? The instruction reports that the absorption of clindamycin through the skin is minimal. The presence of benzoyl peroxide in the composition of the drug does not have any effect on the absorption of the aforementioned substance.
Studies with radiolabeling have shown that benzoyl peroxide is absorbed through the skin only after it is converted to benzoic acid.
Indications
In what cases do you use the drug "Duak"? Acne gel, judging by the reviews, helps very well. This drug is also used topically to treat acne.
Contraindications
Like any medicine, Duac gel has contraindications. These include increased sensitivity, as well as the period of breastfeeding and the age of up to 12 years.
The drug "Duac" (gel): instructions
This medication is intended for external use only to adults and children over the age of 12 years.
The gel is applied once a day (preferably in the evening) to the affected areas of the skin after thorough washing with water and cleansing. Apply the drug carefully (in a thin layer) until it is completely absorbed.
Treatment with this agent should not exceed 12 weeks of continuous use.
Side effects
“Duac” gel can provoke the appearance of such side effects as peeling of the skin, erythema, itching and dryness at the place of application of the medicine, exacerbation of the disease.
Sometimes, against the background of its use, contact dermatitis and paresthesia may occur.
With prolonged use of the drug, the development of bacterial resistance to clindamycin is possible. This may well cause superinfection.
Also, the Duac gel promotes the development of allergic reactions.
Drug interaction
When the gel is combined with local antibiotics, medical, regular or abrasive soaps and cosmetics that have a drying effect, as well as with drugs with a high concentration of binders and alcohol, the patient may experience a cumulative irritating effect.
It is necessary to avoid the use of “Duac” simultaneously with local medicines intended for the treatment of acne, which contain derivatives of vitamin A.
Special recommendations
Treatment with this drug should be carried out with caution in people with ulcerative colitis, regional enteritis and atopic dermatitis.
If you experience diarrhea or abdominal cramps, you should refuse treatment with Duac.
The drug "Duak" (gel): reviews and cost
The price of this drug is quite high. It is about 550-650 rubles. Many patients are unhappy with the cost of the gel. Although experts say that this drug is one of the cheapest and most effective. It very quickly eliminates acne eruptions, making the skin clean and smooth.
The disadvantages of this tool include its inaccessibility (not available in all pharmacies) and the presence of a large number of side effects.