Currently, there are a very large number of medications that can help cope with any pain and problem. At the doctorās appointment, complaints are often heard of musculoskeletal pain, frequent cramps, as well as complaints of feelings of anxiety and poor sleep. In diabetics with damage to small blood vessels, complaints of nervous system disorders appear. After listening and conducting an appropriate examination, the doctor may prescribe the drug "Pregabalin Canon".
Consider the instructions for use of this drug, as well as reviews about it.
The composition and effect of the drug
The main active ingredient of the drug "Pregabalin Canon" is pregabalin. It is an analogue of gamma-aminobutyric acid ((S) -3 (Aminomethyl) -5-methylhexanoic acid).
The drug has antiepileptic and anticonvulsant properties, also an analgesic effect on the body.
What is this effect based on? How does the drug work? Its anticonvulsant and analgesic effect is explained by the fact that āPregabalinā is bound in conjunction with a2-delta protein with calcium channels in the central nervous system, while replacing gabapentin, which resembles gamma-aminobutyric acid.
When taken on an empty stomach, it is absorbed faster. The maximum concentration in the blood with a single dose is achieved after 1 hour. If you take the drug at the same time as food, the time of maximum concentration in the blood is reduced, and the time of the onset of the therapeutic effect is increased by 2.5 hours. But in general, eating does not affect the total absorption time of the active active substance. āPregabalinā does not bind to plasma proteins, penetrates well through the hematoplacental barrier, into breast milk.
āPregabalinā practically does not break down and is excreted by the kidneys unchanged, therefore, patients who have problems with the functioning of the main organ of the excretory system undergo hemodialysis, a lower dose of the drug is recommended, and it should be strictly controlled by a doctor.
With impaired liver function, the dosage does not decrease, since the drug has no effect on this organ.
Who is prescribed the drug
" Pregabalin Canon" is prescribed for patients with the following diseases:
- Fibromyalgia in adults.
- Anxiety disorders in adults.
- Pain, neuropathic in nature.
- With epilepsy as part of the complex treatment of adult patients, in cases with partial convulsive attacks.
It is worth noting that if there are any of the pathologies listed above, you should not start taking the medicine without consulting a doctor.
Who should not take the medicine
It is necessary to pay attention to those who should not take such a drug as Pregabalin Canon. The manual identifies the following categories:
- Hypersensitivity to the components of the drug.
- Children and adolescents under 17 years. No studies have been conducted in this group.
- Pregnant women are not recommended, as there have been no clinical trials.
- When breastfeeding. While taking the drug, breastfeeding should be temporarily stopped.
- Patients of childbearing age should use effective methods of contraception during drug treatment.
With caution, they are prescribed and monitored for such diseases:
- Impaired renal function.
- Heart diseases.
- With diabetes.
- Encephalopathy in the anamnesis.
- Patients over 65 years old.
- Genetic diseases in which carbohydrates are poorly absorbed, since the drug contains lactose, which is not tolerated by everyone.
We examined who is prescribed Pregabalin Canon tablets, what they help with and who should not be used. Next, let's talk about the forms of the drug and its features.
Forms of release of the drug and dosage
The drug is produced in the form of capsules with the following dosage: "Pregabalin Canon" 300, 200, 150, 75, 50 mg.
There is also the drug "Pregabalin Richter." It is also available in capsule form.
Depending on the disease and its neglect, the doctor may prescribe the following dosage of the drug:
- The drug "Pregabalin Canon" 300 mg per day is prescribed for fibromyalgia. It is possible to bring the dose to 600 mg per day.
- Treatment of neuropathic pain is recommended starting with 150 mg per day. Then after a few days, the dosage can be gradually increased and brought to 300 mg. This will depend on the outcome of the treatment. After another week, take 600 mg per day.
- The treatment of epilepsy begins with a dosage of 150 mg per day. The drug must be divided into several methods. "Pregabalin Canon" 300 mg instruction recommends starting to be used no earlier than 7 days later, bringing to this dose gradually, and after another 6 days the dosage is adjusted to 600 mg per day.
- In generalized anxiety disorder, treatment begins with a dosage of 150 mg per day and dividing the amount by three times. Then after 7 days the dose is increased to 300 mg, but if there is no positive effect of the drug, the dose is increased to 450 mg. After another 7 days, if necessary, the dosage is adjusted to the maximum.
- In case of anxiety attacks, the dosage is selected individually. The doctor must take into account the severity and characteristics of the course of the disease. Changing the dosage without consulting a doctor is not permissible.
- If the patient has impaired renal function and is on hemodialysis, treatment is adjusted for creatinine clearance. After passing the hemodialysis session, the patient is prescribed an additional dose of the drug.
You can take the drug at any time, regardless of the meal. In this case, doctors recommend in some cases to take before bedtime for less manifestation of adverse reactions.
I would like to note that it is unacceptable to skip taking Pregabalin Canon medicine. Instructions for use indicate that it is necessary to take the missed dose as soon as possible. But you can not take the missed pill if it is time to take the next one.
Increasing the dosage yourself, without consulting a doctor, can be dangerous to your health.
What is the difference between Pregabalin Richter
The drug "Pregabalin Canon" or "Pregabalin Richter" the difference is insignificant. The instructions are almost similar. They have the same indications and contraindications. Also, the dosage in the treatment of diseases coincides. The active substance is pregabalin. But in each of these drugs there is a small peculiarity:
- The drug "Pregabalin Canon" is produced by a Russian manufacturer, which is its full owner. The medicine is available in the form of capsules from 14 to 56 pcs. in the package, depending on the amount of active substance. It can be from 50 mg to 300 mg.
- The drug "Pregabalin Richter" is an analogue and is produced by a Russian company, but has a representative office in Hungary. The medicine in the form of capsules of 14 pcs. on 1 sheet. There are 4 sheets in a pack. The amount of the main active ingredient is from 75 mg to 300 mg.
I would like to note that the difference between Pregabalin Canon and Pregabalin Richter is still in price. So a Russian-made drug is cheaper than a Hungarian manufacturer.
Possible adverse reactions
If the drug is not taken correctly or its dosage is not observed, the following adverse reactions may occur:
- Drowsiness.
- Dizziness.
- Confusion.
- Lack of coordination of movement.
- Loss of field of vision.
After prolonged use or sudden withdrawal of the drug "Pregabalin Canon", the instructions for use indicate what adverse reactions may occur in this case:
- Blood and lymph system: thrombocytopenia, leukopenia.
- Heart diseases: chronic heart failure, tachycardia, sinus arrhythmia.
- Nervous system: drowsiness, involuntary trembling of limbs, dizziness, impaired attention and coordination, lack of taste sensations, memory loss, stupor, fainting, memory impairment, decreased reflexes, cramps, burning sensation on the skin, psychomotor agitation.
- Psyche: confused consciousness, euphoria, depression, decreased libido, depressed or excited mood, hallucinations, panic attacks, aggression or apathy.
- Vascular manifestations: jumps in blood pressure, cold limbs, "hot flashes."
- Organs of vision: visual impairment, pain in the eyes, dryness, swelling or tearing of the eyes, narrowing of the field of vision, increased brightness of perception, loss of peripheral vision.
- Musculoskeletal manifestations: cramping, pain in the extremities, swelling of the joints, stiffness of muscles, muscle twitching.
- Digestive organs: flatulence, bloating, vomiting, constipation, nausea, diarrhea, exacerbation of pancreatitis, dry mouth.
- Respiratory organs: nasal congestion, snoring, cough, nosebleeds, shortness of breath, dry mucous membranes, pulmonary edema.
- Reproductive and genitourinary organs: urinary incontinence, renal failure, erectile and sexual dysfunction, chest pain, amenorrhea.
- Metabolism: increase or, conversely, weight loss, anorexia, increased appetite
- Skin: rash, urticaria, increased sweating, itching, swelling.
- Immune system: allergic reactions, angioedema, hypersensitivity.
- Perhaps the development of encephalopathy.
It is also possible a feeling of intoxication, falling, pain, chills, increased fatigue, thirst. The most common side effect is confusion, feelings of anxiety and anxiety, drowsiness.
With the appearance of adverse events caused by an overdose, gastric lavage is necessary. Symptomatic therapy is carried out and, if necessary, a hemodialysis procedure.
It is worth noting that with prolonged use of the drug "Pregabalin Canon", dependence may develop. This drug can be classified as narcotic.
Therefore, before taking a drug such as "Pregabalin Canon" instructions for use, reviews should be carefully studied and reviewed. When prescribing, the doctor must take into account all factors of the current disease and the general condition of the patient's body.
Features of use
It should be noted some features of the use of the drug "Pregabalin Canon":
- In diabetics, dosage adjustment is necessary in case of an increase in body weight.
- It is necessary to be careful of older people, especially since when taking the drug, such manifestations as drowsiness, dizziness, confusion were often observed.
- Seizures or epileptic seizures are possible when taking the drug, as well as when it is canceled. Therefore, it is impractical to cancel other anticonvulsant and antiepileptic drugs.
- The manifestation of drowsiness may increase with the joint use of antispastic drugs.
- Problems with the organs of vision are temporary. They may appear or pass both when taking the drug, and after its cancellation.
- If there are problems in the work of the kidneys, after drug withdrawal they pass.
- In elderly people, while taking the drug, chronic heart failure can develop. It is necessary to carefully use this drug in this category of individuals. After its cancellation, such phenomena were not recorded.
- In case of development of angioedema, tablets should be discontinued.
- Perhaps the development of "withdrawal syndrome" after stopping its intake. Therefore, it is necessary to cancel the medicine gradually, during the week, gradually reducing the dosage.
- Cases of development of addiction are recorded. In such situations, medical supervision is necessary.
- The drug "Pregabalin Canon " can cause suicidal thoughts and behavior, so when you take it, you need constant monitoring in case of detection of depressive states, suicidal moods and behavior.
- You should refrain from driving vehicles and mechanisms, as well as from performing work that requires a large concentration of attention. The drug may cause drowsiness, dizziness, and other side effects described previously.
- It is strictly forbidden to use any alcoholic beverages while taking the drug āPregabalin Canonā.
Interaction with other drugs
Since the drug does not reduce or suppress the rate of chemical reactions in the body, it does not affect the metabolism of other drugs, and therefore does not interact with them.
However, attention should be paid to the combined use of certain drugs.
- Drugs that inhibit the central nervous system, together with "Pregabalin Canon" can cause respiratory failure, up to the onset of coma.
- Opioid analgesics in combination with "Pregabalin Canon" have a negative effect on the functioning of the gastrointestinal tract. May cause constipation, intestinal obstruction.
- The simultaneous use of Oxycodone, Lorazepam and Ethanol with Pregabalin can significantly enhance the action of ethyl alcohol and Lorazepam. This is manifested in a violation of consciousness and motor functions. No effect on breathing was detected.
- Oral contraceptives when taken together with "Pregabalin" did not change their effect on the body.
Studies have shown that the drug āPregabalin Canon ā has no interaction at the level of absorption, distribution and excretion with the following drugs:
- "Valproic acid."
- Phenytoin.
- "Carbamazepine."
- "Lamotrigine."
- Lorazepam.
- "Gabapentin."
- "Oxycodone."
- "Ethanol."
And also: "Insulin", diuretics, "Phenobarbital", "Topiramat", "Tiagabin" and oral hypoglycemic drugs.
Next, consider what the reviews on the drug "Pregabalin Canon".
Reviews of doctors about the drug
The drug has been used for a long time and is well known to doctors. About the drug "Pregabalin" reviews of doctors can be heard different. So many have a positive effect in the treatment of epilepsy. A good effect is achieved when relieving pain of a neuropathic nature. Positive results in sleep disturbance and anxiety. In this case, the dosage is strictly controlled by the doctor.
Another category of doctors refers to the drug with caution. Since this drug is used to treat drug-addicted patients. It is believed that such a medicine should be prescribed as a last resort, with very severe pain, with very small doses. The course of treatment should also be short so as not to cause addiction.
The task of each doctor is to determine the feasibility of prescribing this drug, to monitor patients who use it. And also it is necessary to warn those to whom this medicine is prescribed about all possible adverse reactions and about the effect of drug withdrawal.
It is important for the doctor to know when prescribing such a medical product as Pregabalin, the patientās reviews, the tolerance of the components of the medicine, in order to exclude possible negative side effects.
It is worth noting that the drug āPregabalin Canonā is dispensed in a pharmacy only by prescription.
What are the pregabalin drug reviews of patients will be considered further.
Reviews of patients who underwent therapy
Patients respond to the drug mainly on the positive side.
So many note a decrease in pain and the cessation of seizures. Some had a manifestation of side effects, such as drowsiness, dizziness, or urticaria at the initial stage of taking the drug. But after a few days it passed and the effect of the drug was positive.
They also describe the use of Pregabalin in conjunction with other drugs that inhibit the central nervous system. Although the instructions for using the drug describe the possible consequences, which was manifested in the patient. There was a problem with breathing. Timely assistance provided saved a personās life.
Some patients noted a manifestation of side effects with a repeated course of taking the drug. Although for the first time this was not observed. There was a feeling of euphoria or lethargy.
Has "Pregabalin Canon" reviews of various side effects with different medications. They describe it this way: oneās head is spinning, one wants to laugh, or vice versa, depressing thoughts appear, therefore they are afraid to take the drug for a long time.
It should be noted that those patients who adhered to small doses and took the drug for a long time after its withdrawal did not experience the effect of withdrawal, only a slightly depressed state, and then after a short time everything returned to normal.
With prolonged use of the drug "Pregabalin", patient reviews note a decrease in its effectiveness. Therefore, constant medical monitoring is necessary to evaluate the effectiveness of the drug and to analyze the manifestation of side effects.
To summarize, the positive side of the drug "Pregabalin Canon" is its effective action against neuropathic pain and seizures. The drug is not difficult to access, it can be freely purchased with a prescription in a pharmacy.
The negative side is a large number of side effects, as well as the ability to cause drug dependence. Therapy with such serious medicines should be carried out only under the supervision of a doctor and as prescribed.