Treatment of diseases of the musculoskeletal system, removal of pain and inflammation in the joints and muscles is possible thanks to non-steroidal anti-inflammatory drugs, which include the drug “Revmoxicam”. Instructions for this tool include a description of the composition of all dosage forms, pharmacodynamic characteristics, indications and information about the features of use.
Description of the drug
The main active ingredient of this drug is the substance meloxicam from the oxycam group, the basis of which is enolic acid. This tool has a selective effect against inflammatory mediators, which is important for protecting the digestive organs from undesirable processes.
On the preparation "Revmoxicam", the instructions for use describe several dosage forms at once, which allow you to choose the appropriate method of treatment, taking into account the characteristics of the body and associated diseases.
For oral administration, a tablet form with a dosage of meloxicam in one tablet of 7.5 or 15 mg is suitable. Higher-dose tablets are at risk for breaking in half, this allows you to adjust the medication in the absence of lower dosage pills. This dosage form is suitable for long-term treatment.
The injection form is a 1% solution of the active substance, which is released in 1.5 ml ampoules of Revmoxicam. Instruction of injections on the degree and speed of action puts in the first place, which should be considered when choosing a dosage form.
For rectal administration, suppositories with a dose of meloxicam of 0.015 g are used. The basis of the suppository is animal fat, in which the active substance is evenly distributed.
How does the drug work?
The anti-inflammatory, analgesic and antipyretic effect of the drug “Revmoxicam” is based on the ability of the active substance to selectively slow down the processes associated with the synthesis of prostaglandin substances. It is these compounds that mediate inflammatory processes.
The drug "Revmoxicam" describes the instructions for use as a safer medicine compared to other non-steroidal anti-inflammatory drugs. This is due to the slowdown of the enzyme type 2 cyclooxygenase alone, resulting in a decrease in the production of prostaglandin and prostacyclin substances responsible for inflammation. The drug has a negligible effect on type 1 cyclooxygenase, which is why gastroprotective prostaglandins and thromboxanes are produced in the right amount and protect the digestive system from the development of undesirable reactions.
The active substance of the drug “Revmoxicam” (ampoules) describes the instructions for use as a component that does not have a degenerative effect on the cells of the cartilage tissue and does not inhibit the production of proteoglycans, which is observed during treatment, for example, with indomethacin.
The medication does not change platelet aggregation and the duration of bleeding, as occurs with diclofenac and ibuprofen.
Analogs
There are a number of interchangeable drugs on the pharmaceutical market that are similar in action and composition to Revmoxicam. The manual considers analogues as synonyms, which are reproduced in the same dosage form as the original German drug "Movalis" of the company "Beringer Ingelheim".
A variety of meloxicam-based drugs enables patients to be treated both with European (“Meloxicam-Teva”, “Mirlox”, “Melox”), and domestic medicines, which vary widely in price. Among the generic medicines of Russian manufacture, Movasin, Lem, Meloxicam, Arthrosam, Amelotex are distinguished.
A wide variety of synonymous drugs from various manufacturers indicates the widespread use of meloxicam-based medicines.
What is it used for?
The drug “Revmoxicam” recommends the use of injections, tablets and suppositories to eliminate pain, inflammation and degenerative processes in the musculoskeletal system, such as arthrosis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis.
According to the mechanism of action, this tool is suitable for the treatment of various inflammatory processes in the human body. Not all possible indications include the instruction for the medicine “Revmoxicam” (candles). In gynecology, the drug is widely used to treat inflammatory processes of the female genital organs, such as the ovaries. However, only the attending physician can prescribe such an appointment, who will establish the dosage and duration of treatment.
Use of tablets
The drug in tablet form is intended for oral administration. The absorption of meloxicam from the digestive system occurs quickly and amounts to 90%. Food does not affect the penetration of meloxicam through the intestinal mucosa.
The instruction recommends taking the medicine “Revmoxicam” (tablets) together with food, in order to reduce the risk of developing unwanted reactions in the digestive system. The tablet should be swallowed whole, it is not necessary to break it or grind it, it is enough to drink it with a large volume of liquid. The duration of treatment and the dosage of the drug depend on the severity of the disease and is determined by the attending physician.
Treatment of osteoarthritis in adults and adolescents from 15 years of age is carried out with a daily dose of 7.5 mg. If necessary, the doctor can double the daily dose.
Treatment of rheumatoid arthritis and ankylosing spondylitis in adults and adolescents from 15 years of age is carried out with a daily dose of 15 mg. The dosage is reduced to 7.5 mg only after receiving positive dynamics from high-dose therapy.
If there are prerequisites for the development of adverse reactions, patients are prescribed the drug in the smallest single dose of 7.5 mg.
Use of injections
For faster action, the drug “Revmoxicam” (injection) is used, the instructions for use describe parenteral intramuscular administration of the drug. This use is indicated for persons with digestive tract diseases. This is due to the fact that the stomach or intestines do not harm the tablets of the drug “Revmoxicam”. Instructions for the use of injections advises to be injected into the region of the upper outer quadrant of the buttock, deep into the muscle.
The treatment period and dosage of the medicine depend on the severity of the disease and are determined by the attending physician.
For adults and adolescents from 15 years old, sets the dose of the drug “Revmoxicam” instructions for use, injections are given 1 time per day. Typically, 0.75 to 1.5 ml of meloxicam solution is administered. The drug "Revmoxicam" in the form of an injection can be used no longer than 5 days, and then switch to the tablet form of this medication.
After the introduction of the drug, its active substance is 100% absorbed into the systemic circulation, which indicates its high bioavailability.
Not all patients may tolerate high doses of Revmoxicam; instructions for the use of injections for people with renal and hepatic insufficiency recommend that meloxicam be administered at a dose of 7.5 mg. At the same time, indicators of these organs should be monitored to prevent deterioration.
When using several forms of the Revmoxicam preparation at the same time, it is recommended to combine the injections, tablets or suppositories so that the dose recommended for daily use is not overestimated.
Instructions for the use of candles
The medication can be used rectally, by introducing a suppository into the rectum for further absorption of the active substance by the blood vessels in the rectum and further penetration of meloxicam into the bloodstream.
To implement this procedure, you must first prepare by conducting hygienic manipulations. Candles "Revmoksikam" instructions for use recommend unpack and enter with well-washed hands, so as not to bring the infection into the anus.
Candles of this drug are made of solid fat, they quickly melt in the hands, so the introduction of a suppository after opening the primary packaging should be immediate. The term of use and dose depend on the type of disease and severity, but in any case, the doctor prescribes all appointments.
The rectal use of meloxicam allows good absorption in the systemic circulation, with a bioavailability of about 90%. A stable therapeutic content in plasma occurs after 5 days from the start of therapy.
For adults and adolescents from 15 years of age, “Revmoxicam” candles are prescribed for use, using no more than 1 suppository once a day.
The maximum amount of meloxicam per day should be about 15 mg, which corresponds to 1 suppository.
According to the instructions for use, the drug can be administered rectally for no more than a week, and for further treatment it is necessary to switch to the use of the tablet form of the medicine “Revmoxicam”.
When you can not use the drug
It is not always possible to treat with Revmoxicam medication, the instructions for use include a list of contraindications for which this remedy is not used.
- With increased individual sensitivity to oksikam and other non-steroidal anti-inflammatory drugs, this drug is canceled.
- Do not use the tablet form of the drug in patients who suffer from malabsorption of glucose and galactose, with signs of lactase deficiency and individual intolerance to galactose molecules.
- Treatment with the drug is contraindicated for people with peptic ulcer in the stomach and duodenum, with liver diseases, heart failure and severe kidney and heart failure, and those who underwent coronary artery bypass grafting.
- Do not use the drug in patients who are at high risk of bleeding, especially if there was cerebrovascular or manifest gastrointestinal bleeding.
- The drug "Revmoxicam" in the form of suppositories is not used in patients who have diseases of the rectum of various origins. Contraindication is also the inflammatory process of the rectum.
- Pregnant and lactating women, children under 15 years of age, the drug is not prescribed due to its toxic effect on the growing body.
- The drug "Revmoxicam", injection, the instruction prohibits the use of intravenously, only intramuscular injection into the gluteal muscle is acceptable .
With caution, the drug is prescribed for patients who have bronchial asthma, cirrhosis of the liver, dehydration, diseases of the urinary system, congestion in heart failure, and decreased renal blood flow.
Elderly patients, people with a weakened body or who are on anticoagulant therapy should take this medication under the supervision of a doctor.
Particular caution is required when treating patients with a peptic ulcer in the stomach and duodenum and other diseases of the digestive tract in the past.
Combination with other medicines
The simultaneous combination of some drugs with the drug "Revmoxicam" can mutually enhance or reduce their effectiveness, cause unwanted reactions.
- The combined use of meloxicam and a non-narcotic pain medication leads to an increased risk of ulcers on the mucous membrane of the digestive organs or even bleeding.
- It is not recommended to combine the drug “Revmoxicam” with anticoagulant and thrombolytic drugs that provide anti-aggregation of blood cells.
- The simultaneous use of meloxicam and diuretics against the background of general dehydration of the body can provoke acute renal failure in such people. If reception cannot be refused, then constant monitoring of kidney function is needed .
- The simultaneous use can cause a decrease in the therapeutic effect of intrauterine contraceptives, beta-adrenergic blocking, vasodilating, diuretic drugs and medications involved in the inhibition of angiotensin-converting enzyme.
- In combination with methotrexate, the drug "Revmoxicam" is able to enhance the toxic effect on blood cells, while concomitant use with cyclosporine leads to a negative effect on the functioning of the kidneys. If there is a need for such a combination, then periodic monitoring of the state of the blood along the periphery and kidney function is needed.
- The effect of the drug is aimed at increasing the concentration of lithium ions in the blood plasma. The combination of colestyramine with the drug "Revmoxicam" leads to a decrease in the half-life of the active substance.
- The action of this non-steroidal anti-inflammatory drug is aimed at changing the effectiveness in the work of tablet hypoglycemic drugs, including those containing insulin. For patients with high blood sugar, taking the drug “Revmoxicam” requires monitoring glucose in the blood plasma in order to subsequently adjust the dose of sugar-lowering medications.
Reviews about the drug
As you can see, the range of use of the drug “Revmoxicam” is diverse, the instructions do not describe the reviews, but it describes all the undesirable consequences of using this drug, all contraindications and interactions. Such information does not mean that all adverse reactions must necessarily occur after taking meloxicam-based medication. Treatment can take place without significant adverse effects for the body, and the therapeutic effect will be noticeable. Each organism is individual and reacts differently to various substances.
As already noted, not all indications for use are described in the instructions, but only those that relate to the treatment of rheumatic pathologies of the musculoskeletal system.
Being an anti-inflammatory drug, the drug "Revmoxicam" has been widely used for the treatment of fractures, as part of the complex therapy of inflammation in chronic prostatitis, inflammatory processes of the gynecological area.
To quickly relieve pain, it is recommended to use injections for the Revmoxicam preparation. Reviews about the effectiveness of such injections sound mixed.
Some patients almost immediately feel better, the pain recedes, the drug is not suitable for others, and a replacement must be sought.
For the treatment of rheumatic conditions, meloxicam tablets are used, which can be taken for a long time, however, such treatment can cause digestive disorders in many, which also requires the withdrawal of the medication.
There are positive reviews about the combination therapy of adnexitis when, in combination with injectable anti-inflammatory drugs, “Revmoxicam” suppositories are used.