What do you know about a drug like Tiamazole? Instructions for use, price, reviews, analogues and the purpose of this medication will be presented later.
The form of the drug, its composition and description
What is the drug "Tiamazole"? Instructions, descriptions state that this tool is made in the form of round tablets, coated with a white or yellowish shell. The composition of this medicine includes the same active ingredient - tiamazole, as well as other excipients.
We can not say that the mentioned component is contained in many other drugs that have similar properties.
Pharmaceutical Action
What is Tiamazole? The instructions for use claim that this is an antithyroid drug that can disrupt the synthesis of thyroid hormones, reduce the internal secretion of T4, and also block an enzyme such as peroxidase, which is involved in the iodination of tyrone with the formation of diiodothyronine and monoiodothyronine.
It should also be noted that the active substance of this medication significantly accelerates the excretion of iodides from the thyroid gland, reduces the main metabolism, increases the excretion and reciprocal activation of the synthesis of TSH by the pituitary gland.
The therapeutic effect after the use of this drug depends on the initial concentration of T4 and T3. But as a rule, the concentration of hormones in the human body normalizes after seven weeks after constant administration of the drug in a dosage of 30 mg or after 28 days when using 40 mg of the drug.
After five days after the abolition of the drug, the concentration of hormones can again increase.
Indications for the appointment of tablets
What is the purpose of using the medicine “Tiamazole”? Instructions for use informs that this drug is intended for the treatment of thyrotoxicosis (diffuse struma). Also, it is often used in the preoperative period for the purpose of intermediate and preliminary therapy (in addition to radio treatment). In addition, this medication can be prescribed for nodular goiter and relapse (postoperative) thyrotoxicosis.
Prohibitions for appointment
When can you not use the medicine "Tiamazole"? The instruction for use states that the following conditions are contraindications for this drug:
- high sensitivity to components;
- feeding period;
- severe granulocytopenia or leukopenia (including a history).
We can not say that with caution this medication is used during pregnancy, with liver failure and large goiter, especially with narrowing of the trachea (it is allowed only as a short-term treatment during preparation for surgery).
Medication "Tiamazole": instructions for use
The composition of this drug was presented above.
How should the drug in question be used correctly? It is prescribed only inside. The daily dosage of the drug is usually divided into 2 or 3 doses.
At the very beginning of treatment, single doses of the drug are used at a strictly set time. As for the maintenance dose of the drug, it must be taken in one dose, immediately after breakfast.
For adults with thyrotoxicosis therapy, this medication is prescribed in an amount of 20-40 mg per day. In the euthyroid state, the indicated dosage is gradually reduced to a maintenance level of 5-20 mg per day (for 3-7 weeks). This administration of the drug continues for 1-1.5 years.
For pregnant women, the medication in question is prescribed in minimum doses, that is, 2.5-10 mg.
Side effects
What reactions of an undesirable nature may cause Tiamazole? Instructions for use indicate the following negative effects:
- fever, nausea, severe weakness, vomiting, agranulocytosis, epigastric pain, granulocytopenia;
- violation of the liver, aplastic anemia, hepatitis, paresthesia, cholestatic jaundice;
- thrombocytopenia, dizziness, hypoprothrombinemia, headache, itchy skin, neuritis, urticaria, polyneuritis, rash, taste disturbance;
- joint pain, autoimmune insulin syndrome, periarteritis, muscle pain, swelling, generalized lymphadenopathy, skin hyperpigmentation, sialadenopathy, lupus-like syndrome, alopecia, weight gain, nephritis, clinical and subclinical hypothyroidism.
Cost, reviews, analogues
Now you know what Tiamazole is. Instructions for use, the price of this medication is presented in this article.
You can replace the drug in question with such means as Timidazole, Antiroid, Danantisol, Bazolan, Favistan, Merkazolil, Merkazol, Metimazol, Tapazol, Metotirin, Tikapzol "And others.
The cost of "Tiamazole" is about 150-180 rubles.
Reviews about this medicine are mostly positive. Patients claim that this drug manifests itself as a highly effective antithyroid drug. Its regular use has a positive effect on the course of a disease such as thyrotoxicosis. In addition, this tool is often used as an additional drug for radioiodine therapy. It also works well with nodular goiter.
The negative sides of this drug include the presence of many side effects.