"Vesikar" - a drug that helps to reduce the tone of the smooth muscles of the genitourinary system. The drug belongs to the group of antispasmodics. Used to eliminate urological diseases. In this article, you can read in more detail the reviews and instructions for use with Vesicar 5 mg.
Structure
According to the instructions, Vesikar is produced in tablet form. Film-coated capsules, the drug is available in the following dosages of five and ten milligrams. The tablets are placed in blisters, a total of ten or thirty capsules.
An active microelement is solifenacin succinate. One tablet contains 5 mg of Vesicara. According to the instructions, the following components are additional substances:
- lactose;
- starch;
- hypromellose;
- a salt of magnesium and stearic acid.
Substances in the shell structure:
- ethylene glycol polymer;
- hypromellose;
- talc;
- titanium dioxide;
- dyes.
Pharmacological properties
Solifenacin has a pronounced antispasmodic effect. The active substance is a specific competitive inhibitor of serpentine receptors. Moreover, the main component does not show or has a small degree of similarity to other nerve endings and ion channels.
The pharmacological effect of the drug is observed already in the first seven days of therapy, it comes to a stable state in the next three months of taking "Vesicar". The maximum therapeutic effect is achieved after about thirty days of therapy. The effectiveness of the treatment lasts up to twelve months.
The maximum content of an active trace element in the blood is achieved eight hours after the use of the drug. In this case, the level of maximum concentration increases equivalent to an increase in dosage from five to forty milligrams. The absolute bioavailability of the active substance is ninety percent. About ninety-eight percent of the main trace element comes into contact with blood proteins. The absorption rate is not affected by eating.
Solifenacin succinate is broken down in the liver to one main and three inactive metabolic products. The half-life of the active trace element is from forty-five to sixty-eight hours. It is excreted with urine and feces.
Indications
"Vesikar" is used in symptomatic therapy of patients with hyperactivity of the bladder, which is accompanied by:
- imperative urinary incontinence;
- sudden urge to empty the bladder;
- frequent going to the toilet.
Contraindications
The following conditions are considered a ban on the use of "Vesicar":
- Ishuria (urinary retention).
- Kidney disease.
- Angle-closure glaucoma (a group of chronic diseases of the visual organ, which is characterized by attacks of increased intraocular pressure).
- Digestive disorders.
- Myasthenia gravis (autoimmune neuromuscular disease).
- Conducting hemodialysis.
- Galactosemia (a hereditary disease resulting from disorders of carbohydrate metabolism).
- Lactase deficiency (a disease that is accompanied by the inability of the human body to digest milk sugar due to insufficient production of lactase in the intestine).
- A disease that is associated with impaired absorption of simple carbohydrates in the intestine.
- Sensitivity to the main component of the drug.
- Children under eighteen.
Instructions for use
The recommended dosage of the drug for adult patients and people of retirement age is five milligrams per day. If necessary, the dosage can be increased to ten milligrams per day. Capsules are taken orally, whole, every day (at the same time), regardless of food.
Side effects
When using "Vesicar" in rare situations, negative reactions can occur. From the central nervous system, a mild headache may occur.
From the side of the visual organs:
- Poor visual perception.
- Xerostomia (dry mucous membranes of the eye).
- Glaucoma (a large group of eye diseases, characterized by an increase in intraocular pressure above normal).
From the side of the digestive system, the following can occur:
- Nausea.
- Dyspepsia (damage to the normal activity of the stomach and intestines, difficult and painful digestion).
- Pain in the abdomen.
- Chronic disease, which is characterized by constant reflux of gastric juice into the esophagus.
- Loss of appetite.
In addition to these phenomena, the following can be observed:
- Dysuria (violation of urination).
- Urinary tract infection.
- Cystitis.
- The pathological condition due to the inability to empty the bladder.
- Dry nasal mucosa.
- Dry skin.
- Urticaria (skin lesion of an allergic etiology, which is characterized by the appearance of itchy blisters).
- Erythema multiforme (acute inflammation that affects the skin and mucous membranes).
- Exfoliative dermatitis (a common disease of human skin).
If negative reactions occur, it is necessary to reduce the dosage or completely stop taking the drug, then you need to rinse your stomach and take activated charcoal. If necessary, prescribe drugs of combined action.
Features
With extreme caution, the drug is recommended for people with the following diseases:
- Violation of the natural outflow of urine in the urinary system, which is characterized by increased pressure in the ureters, bladder, kidneys.
- Esophageal and gastric motility disorders.
- A pathological condition manifested as a result of a pathological displacement of the internal organs that are located under the ribs.
- Gastroesophageal reflux.
- Autonomic neuropathy (disorders of the nervous system associated with a lesion in diabetes of small blood vessels).
- Hypokalemia (low concentration of potassium ions in the blood).
When treating with "Vesicar", it is necessary to remember the following points:
- Before therapy, make sure that there are no other reasons that can provoke involuntary urination.
- If an infection of the genitourinary system occurs, antibiotic therapy is necessary.
- There is no need to adjust the dosage for patients of retirement age.
- The drug should not be taken by persons under the age of eighteen.
- With solifenacin therapy, it is necessary to take a break of one week before using anticholinergics.
- The drug can cause damage to the organs of vision.
Interaction with other drugs
When used with M-cholinomimetics, the therapeutic effect of solifenacin is reduced. With the joint use of "Vesicar" with atropine-like drugs, the pharmacological effect and adverse reactions of solifenacin increase.
When taking "Vesicar" the therapeutic effect of medicines that stimulate the motility of the digestive system is reduced.
Do not combine solifenacin with diltiazem and phenytoin.
Can I use Vezikar during pregnancy?
Clinical information about the safety and effectiveness of taking "Vesicar" in women in position is not available, so it is necessary to take the drug with caution during pregnancy.
There is no information on the release of solifenacin into breast milk. The medicine is not recommended to be taken during lactation.
"Vesikar": analogues
The drug-substitute for the current component is the medicine "Zevesin".
The following drugs are considered analogues of "Vesicar" in therapeutic effect:
- Sibutin.
- "Novitropan".
- Spazmeks.
- "Driptan."
- "Urotol".
- "Detruzitol".
- Betmiga.
- Drimtan Apo.
- Zevesin.
The cost of "Vesicar" varies from 800 to 1500 rubles.
Driptan
The drug is an analogue of "Vesicar", according to the instructions for use, the medicine is a tool whose pharmacological effect is aimed at decreasing the tone of the smooth muscles of the genitourinary system.
"Driptan" is made in the form of tablets for oral administration. Capsules are milky in color, rounded, with a risk on one side. The drug is dispensed in pharmacies in blisters of thirty pieces. In total, one or two blisters are in the package.
The main active ingredient of "Driptan" is oxybutynin hydrochloride, one capsule contains five milligrams of the active ingredient.
The drug has an antispasmodic effect. The main trace element has an m-anticholinergic effect, relaxes smooth muscles, eliminates muscle spasm. Under the influence of the medication, the capacity of the bladder increases, the functioning of the sphincter of the bladder normalizes. The cost of the drug is 600 rubles.
How to store the drug?
"Vesikar" must be kept in a place protected from moisture and sunlight, away from children. Shelf life is thirty-six months, according to the instructions.
Vesikar: reviews
According to people, the drug does not always have the promised pharmacological effects. In addition, a large number of patients narrate in their responses about the occurrence of pronounced side effects. The price of "Vesicar" is estimated as overpriced.