Poisoning with heavy metals, low-quality alcohol and other substances should be treated immediately. Otherwise, it can be fatal.
Modern pharmaceutical companies produce many detoxifying agents. They are necessary for the rapid removal of toxic compounds from the human body, significantly facilitating its condition.
The most popular anti-poisoning drug is Unithiol. Instructions for use, reviews of doctors about the effectiveness of this medicine, we will consider below.
Description, composition, release form of the medication and its packaging,
In what form can a drug “Unithiol” be found in a pharmacy? Instructions for use (this medication is not performed in tablets) indicates that the agent is available in the form of a clear solution, which is intended for subcutaneous or intramuscular administration. It has a faint smell of hydrogen sulfide, as well as a light pink color (may be colorless).
What are the components of the Unithiol preparation? The instruction for use states that the active ingredient of this agent is sodium dimercaptopropanesulfonate monohydrate. The medication also includes auxiliary compounds in the form of sulfuric acid, disodium edetate (Trilon B) and water for injection.
On sale, this medicine comes in ampoules of glass of 5 ml. They are packed in contour cells, which are placed in bundles of paper.
Pharmacodynamic properties
How does Unithiol Medication Work? Instructions for use report that it is a detoxification agent that quickly eliminates the deficiency of sulfhydryl groups. In its mode of action, this drug is very close to complexones.
According to experts, sulfhydryl groups are able to react with thiol poisons in the blood and tissues, while forming harmless complexes evacuated with urine.
Blocking poisons helps to restore the work of all enzyme systems in cells that have been affected by toxic substances. This drug is used as an antidote for poisoning by arsenic, heavy metals and their compounds.
In people with polyneuropathy of diabetic origin and with secondary amyloidosis, this medication weakens pain, improves the performance of NS, and also regulates the permeability of capillaries.
Kinetic features
What kinetic properties are inherent in the Unithiol medication? Instructions for use states that after subcutaneous or intramuscular injection, the drug molecules actively penetrate the bloodstream. The highest concentration of the drug is recorded after about 40 minutes (after i / m administration).
The half-life of the drug is two hours. The drug is excreted together with urine in the form of products of incomplete oxidation.
Solution indications
At what indications can the patient be prescribed Unithiol medication? Instructions for use (injections should be carried out only by an experienced medical professional) indicates that this tool is used for:
- intoxication with bismuth, arsenic, chromium, mercury or cardiac glycosides;
- chronic alcoholism and delirium tremens as part of combination treatment;
- hepatocerebral dystrophy (Wilson-Konovalov syndrome).
Contraindications
Are there any contraindications for Unitiol? The instruction for use states that the drug in question cannot be prescribed for:
- sensitization to the drug;
- liver failure;
- at a minor age;
- pregnancy
- arterial hypertension;
- breastfeeding.
The drug "Unithiol": instructions for use
In ampoules, this tool can be purchased at any pharmacy. According to the instructions, this drug must be administered subcutaneously or intramuscularly.
In the treatment of arsenic intoxication, the medication is used at the rate of 50 mg of the active ingredient per 10 kg of the victim's weight (that is, 250-500 mg). On the first day of treatment, the indicated dosage must be administered up to 4 times, on the second - up to 3 times, and on the next one time.
In the treatment of poisoning with mercury salts, the drug is used according to the above scheme for seven days or until the signs of intoxication disappear completely.
In the treatment of cardiac glycoside poisoning, on the first and second days, the drug is administered at the rate of 50 mg of the active component per 10 kg of the patient's weight (i.e. 250-500 mg) four times a day, and on the next day twice or until the symptoms of cardiotoxicity disappear.
In the treatment of hepatocerebral dystrophy, the medication is administered intramuscularly in a dose of 5-10 ml in standard concentration every day or two days later. The duration of therapy is 26-30 injections. If required, the course is repeated after 4 months.
For the treatment of chronic alcoholism, the drug is used in an amount of 4-5 ml in standard concentration up to 3 times a week.
In the treatment of delirium, the drug is administered once (5 ml in standard concentration)
Side effects
When using the drug in question, adverse reactions are extremely rare. In some cases, the patient develops tachycardia, dizziness, nausea, and pallor of the skin. In addition to the above, allergic reactions may occur.
Overdose and drug interactions
In case of an overdose, the patient develops shortness of breath, hyperkinesis, lethargy, convulsions and lethargy. In this case, symptomatic therapy is performed.
This drug is pharmacologically incompatible with agents that include heavy metals, as well as with alkalis. Also, he is not appointed with "Atsizol."
Reviews
Consumer reviews about the tool in question are extremely rare. This is due to the fact that this medication is used mainly in inpatient practice.
As for experienced doctors, they speak of Unitiol as a very effective and effective tool that evacuates toxins, including in case of alcohol poisoning.