Prednisolone is a semi-synthetic glucocorticoid drug based on hydrocortisone. That is, it is a tool with a high degree of biological activity, which allows the use of prednisolone injection in clinical situations. For example, in the provision of immediate emergency care.
Antiallergic, anti-inflammatory, immunosuppressive effect, the ability to increase the sensitivity of beta-adrenergic receptors (these are proteins of the outer cell membrane that recognize and bind synthetic analogues of catecholamines with adrenaline and norepinephrine) to endogenous catecholamines (that is, active substances that serve as chemical “governing” molecules of neurogens ( ) and mediators in intercellular interactions) - the main functions of the drug "Prednisolone". Ampoules for injection are available in volumes of 25 mg.
Emergency conditions, such as acute allergic reactions, thyrotoxic crisis, asthmatic status in bronchial asthma, shock, not amenable to standard therapy (surgical, burn, toxic or anaphylactic, traumatic or cardiogenic), acute renal or liver failure, acute adrenal insufficiency, are Indication for the use of the drug "Prednisolone".
Injections are also prescribed for rheumatic diseases (rheumatoid arthritis or systemic lupus erythematosus), for acute hepatitis and cirrhosis of the liver, bronchial asthma, as well as to reduce inflammatory processes and prevent the appearance of cicatricial narrowing of tissues and blood vessels during poisoning with cauterizing fluids.
The dosage and duration of the course of treatment is determined by the doctor individually, depending on the severity of the disease and the indications for the drug "Prednisolone". Injections are administered intravenously by means of droppers (first by stream, then by drip) or intramuscularly if intravenous administration is not possible. After the acute condition has been stopped, Prednisone is prescribed in tablets for oral administration. In this case, the dosage is gradually reduced. If the course of treatment is long, then therapy should not be stopped abruptly.
This drug is effective, but it has enough contraindications and side effects. First, contraindications means "Prednisolone". Injections are not applied even for health reasons, if there is intolerance or hypersensitivity to the constituent components. The drug should be prescribed with caution in case of ailments such as recently transferred or existing infectious diseases of a viral nature, gastrointestinal diseases, the vaccination period (as well as eight weeks before and two weeks after vaccination), immunodeficiency states.
In case of cardiovascular, endocrine diseases, severe chronic liver or kidney failure, systemic osteoporosis, prednisolone should also be used with caution. Injections during pregnancy, especially in the first trimester, as well as for children during the growth period, are used only according to vital indicators and strictly under the supervision of the attending physician. If the drug is prescribed during lactation, breastfeeding is recommended to stop.
Among the side effects of prednisolone are a decrease in the body’s ability to use glucose as an energy source, inhibition of adrenal function, steroid diabetes, increased intracranial pressure, a steroid ulcer of the duodenum and stomach, increased blood pressure, bradycardia (sometimes until cardiac arrest), increased excretion of calcium, delayed sexual development in children, trophic changes in the cornea. Moreover, these are far from all side effects. A complete list must be found in the instructions for use with the drug "Prednisolone".