Nalgesin Forte tablets are a non-steroidal anti-inflammatory drug that has antipyretic and analgesic effects. The mechanism of its work is directly related to non-selective inhibition with respect to cyclooxygenase activity. The tablets of the drug are film-coated, readily soluble and quickly absorbed from the gastrointestinal system, ensuring the onset of the analgesic effect.
Pharmacokinetics
Instructions for use for the Nalgesin Forte preparation indicate that absorption from the digestive system occurs very quickly, bioavailability is ninety-five percent, so eating does not affect either the speed or completeness of the absorption process. Chemical bonding with plasma proteins exceeds ninety-nine percent. The metabolism procedure is carried out in the liver to dimethylnaproxen with the direct participation of the enzyme system. Ninety-eight percent of the substance is excreted in the urine, ten of which leave the human body unchanged. With bile it leaves up to two and a half percent. Against the background of renal failure, cumulation of metabolites is likely.
Indications for use of the drug
According to the instructions for use of "Nalgesin Forte", it is prescribed to patients as part of the treatment of the following diseases:
- Pathologies of the musculoskeletal system, for example, rheumatoid, psoriatic, juvenile arthritis in a chronic form, as well as ankylosing spondylitis, soft tissue damage, osteoarthritis of the spine and peripheral joints, along with radicular syndromes, tendovaginitis and bursitis.
- In case of mild or moderate pain, we are talking about neuralgia, ossalia, myalgia, lumbar ischialgia, post-traumatic consequences of sprains and bruises that are accompanied by inflammation, as well as postoperative complications in the field of gynecology, traumatology, orthopedics and maxillofacial surgery. In addition, the drug is taken for headaches, migraines, algodismenorea, adnexitis and toothache. This is confirmed by the tool "Nalgezin Forte" reviews.
- The drug is suitable for use in the complex therapy of infectious and inflammatory ailments of the nose, ear and throat with a pronounced pain syndrome in the form of tonsillitis, pharyngitis and otitis media.
- The use is also relevant for febrile syndrome against colds and infectious diseases. "Nalgesin Forte" is used in a complex of symptomatic treatment in order to get rid of pain, inflammation, and also to reduce elevated body temperature. This medicinal product does not affect the progression of the main disease.
Forms of release and composition of the medical product
For the Nalgezin Forte medication, the instructions for use indicate that the tablets are film-coated and each of them is five hundred and fifty milligrams.
The active substance is naproxen sodium. Auxiliary elements are povidone, talc, magnesium stearate and purified water. The film shell is made of Opadry YS-1 dye, which is a ready-made mixture of titanium dioxide E171, as well as macrogol, indigo carmine and hypromellose. The composition of Nalgesin Forte is of interest to many.
Dosage regimen and instructions for use of the drug
Tablets are recommended to be taken orally and washed down with several sips of water. As part of the use of the drug as an analgesic, its average daily rate is two to four tablets, that is, up to a thousand milligrams per day. In the case of very severe pain and no history of gastrointestinal diseases, the attending physician may increase the daily amount to six tablets, but such therapy should last no more than two weeks. When used as an antipyretic medicine, its initial dose should be two tablets, after which it is advisable to take one every six to eight hours. This is confirmed by the Nalgezin Forte reviews.
If it is necessary to prevent all kinds of migraine attacks, doctors recommend taking two tablets twice a day. True, treatment should be discontinued if the intensity, frequency and duration of migraine attacks do not decrease within a month. Already at the onset of the first signs of migraine attacks, it is recommended to drink three tablets, and in extreme cases, one or two more after half an hour.
In order to alleviate and eliminate painful menstrual symptoms and cramps, the drug is prescribed in a starting dosage of two tablets, and then one at a time every six to eight hours.
Against the background of an acute attack of gout, the initial dose is prescribed in three tablets, then two after eight hours, and later one tablet until the attack is completely stopped. This is confirmed by the "Nalgezin Forte" instructions for use.
During the treatment of rheumatoid forms of diseases, such as ankylosing spondylitis and osteoarthritis, the initial dose of a medicinal product should be two to four tablets twice a day in the morning and evening. The initial daily norm, which is from three to six tablets, is recommended for patients with pronounced night or morning stiffness, as well as people who have been transferred to treatment with naproxen sodium after taking other painkillers in excessive doses, and those who have pain leading symptom.
The usual average daily rate is expressed in two to four tablets, which are prescribed in two divided doses. Morning along with the evening dose of "Nalgezin Forte" tab. p / o 550mg No. 10 may not be the same. After consulting with your doctor, you can change them depending on the presence of certain symptoms. For children who are older than nine years old or with a body weight of more than twenty seven kilograms, this product is prescribed in a daily norm of ten milligrams per unit weight in two divided doses.
Side effects
As a rule, these or those side effects associated with the use of the drug "Nalgesin Forte" are most common when used in high doses.
So, on the part of the digestive system, the following consequences occur: abdominal pain, constipation, dyspepsia, diarrhea, nausea, ulcerative stomatitis and erosive lesions. In addition, bleeding, pathology of liver functions and an increase in the activity of its enzymes, bloody vomiting, jaundice and melena occur. On the part of the central nervous system, headaches, hearing loss, sleep disturbances, drowsiness, depression and disruptions in concentration are often found. There is also a slowdown in the reaction rate, aseptic meningitis, as well as cognitive dysfunction, are possible.
As dermatological reactions, itching, ecchymosis, increased sweating, alopecia and photodermatosis are possible. On the part of the sensory organs, patients observe the appearance of tinnitus, impaired vision and hearing. The cardiovascular system responds to an excess of this drug in the form of puffiness, shortness of breath, palpitations, as well as congestive heart failure and vasculitis. Analogs of “Nalgesin Forte” will be considered below.
The genitourinary system malfunctions in the form of glomerulonephritis, hematuria, interstitial and nephrotic syndrome, and, in addition, renal failure and papillary necrosis along with menstrual irregularities.
On the part of the hematopoietic system, patients complain of eosinophilia, granulocytopenia, leukopenia, thrombocytopenia, aplastic and hemolytic anemia. Malfunctions of the normal functioning of the respiratory system are expressed in eosinophilic pneumonitis. Allergic reactions are accompanied by skin rash, urticaria, angioedema, epidermal necrolysis, erythema multiforme, as well as Stevens-Johnson syndrome. This confirms the instructions for use for tablets "Nalgezin Forte".
In addition to all other side effects, thirst, hyperthermia, hyperglycemia, hypoglycemia, and, in addition, an increase in the duration of bleeding are also likely.
Contraindications Nalgezin Forte
This drug is not suitable for use by patients suffering from the following ailments:
- The drug should not be used in the period after the recent completion of coronary artery bypass grafting.
- Erosive and ulcerative pathologies of the stomach or duodenum, as well as significant gastrointestinal bleeding.
- Inflammatory bowel disease in the acute phase, such as ulcerative colitis and Crohn's syndrome.
- Cerebrovascular bleeding or hemostatic disorders, in addition, severe liver failure and active disease of this organ.
- Pronounced renal failure, including confirmed hyperkalemia and the presence of progressive kidney disease;
- The process of suppression of bone marrow hematopoiesis, the onset of pregnancy along with breastfeeding.
- Anamnestic information about attacks of rhinitis, bronchospasm, urticaria due to the use of acetylsalicylic acid, or another non-steroidal anti-inflammatory drug in this case we are talking about a complete or partial intolerance syndrome of such substances.
- Excessive sensitivity to naproxen sodium.
"Nalgesin Forte" 550 mg is contraindicated in children under the age of fifteen. For older people who are over sixty five years of age, this product is prescribed no more than two tablets per day.
Special instructions for the drug
In order to reduce the factors of development of undesirable manifestations from the digestive organs, it is recommended to use the minimum effective dosage with the shortest course. In the event that the pain along with the fever persists, or becomes stronger, it is necessary to go for a consultation with a doctor.
With special care, Nalgezin Forte should be prescribed for ischemic heart diseases, cerebrovascular pathologies, and, in addition, for hyperlipidemia and diabetes mellitus in combination with smoking. In addition, it is necessary to refrain from treatment with this drug in case of the presence of Helicobacter pylori infection, with prolonged use of non-steroidal anti-inflammatory products and against the background of frequent alcohol consumption, since in this case erosion, ulcers and bleeding may occur.
Only after consultation with a doctor, it is recommended to take this drug to patients suffering from bronchial asthma, blood clotting disorders, as well as patients with hypersensitivity to all kinds of analgesics.
Patients with liver disease and renal failure are also prohibited from using Nalgezin Forte. In extreme cases, such patients will have to control creatinine clearance. With an indicator of this element below twenty milligrams, it is strongly not recommended to appoint a product. In the case of chronic alcoholic and other types of cirrhosis, the concentration of the active substance of the drug in the body increases significantly, for this reason, for this category of patients, the use of the product in the lowest possible doses is recommended.
"Nalgesin Forte" should not be used along with other drugs and analgesics with anti-inflammatory properties, except for appointments of the attending physician. You should also avoid taking this medication for two days before surgery. Each tablet contains about twenty-five milligrams of sodium, which should be considered when following a diet with limited salt intake.
Analogs of "Nalgezin Forte"
In case of intolerance to one or another component, as well as in order to select the most budget option for patients, there are several analogues of this medication.
One of them is Ibuklin. This is a more cost-effective analogue of the product in question, having the same release form, but having a slightly different composition. It used immediately two active elements, namely ibuprofen in combination with paracetamol. This analogue is prescribed for inflammatory diseases of the musculoskeletal system, fever, as well as for manifestations of toothache and headache. This is indicated by the instructions for use. The Nalgezin Forte analogs do not end there.
Naproxen-Acre is a drug of Russian origin. It is sold in cartons of thirty tablets. The active substance here is the same as that of Nalgesin Forte, for this reason the instructions for use are not distinguished by fundamental differences. This analogue is one hundred rubles cheaper.
In addition to those already presented, “Algezir Ultra”, “Naprobene”, “Pronaxen”, “Sanaprox” and others are also analogues.
Reviews
In their reviews, people mostly write that they consider this medication to be quite effective and that it must be present in each family’s first-aid kit as an active pain reliever. People recognize the drug as a fairly safe remedy for various types of spasms.
Core patients share that this medicine is quite suitable for them and does not cause side effects, as is characteristic of other tablets. The price of three hundred rubles, judging by the comments, also suits buyers. What helps Nalgezin Forte? What do people write about this?
According to reviews, the drug perfectly helps to cope with migraines and has a quick analgesic effect, which is important for most people.
Women note the positive qualities of the drug when used during critical days. Especially it helps those who suffer from very strong menstrual pains that are difficult to endure. Men report in reviews that they use Nalgezin Forte for pain in the spine, as well as during toothaches.
Many people note that these are almost the only pills that they always carry with them in their bags or pockets. Among other things, buyers also note the effectiveness of Nalgezin Forte, which helps them cope with the first symptoms of a cold with the onset of fever and flu. In the comments, it is reported that cheaper analogues in such situations, unfortunately, do not help.
Output
Thus, at the moment, “Nalgesin Forte” is recognized as the most effective drug that helps to cope with any, even the most severe spasmodic reactions that occur in the human body, whether it be tooth, muscle, menstrual or postoperative pain. According to the assurance of both doctors and patients, its main advantages are the absence of side effects and relatively low cost.
We reviewed the instructions for use with "Nalgezin Forte", composition and analogues.