The drug "Legalon" is available in the form of capsules and infusion solution. The active ingredient is silymarin.
The antioxidant activity of the drug is associated with the ability of the active substance to bind all free radicals. As a result, the pathophysiological lipid peroxidation is prevented or interrupted , which provokes the destruction of cell membranes. Thus, the loss of soluble components in the liver cells is limited or stopped (transaminases in particular).
The active substance of the drug slows down the penetration of individual hepatotoxic components into the cell (for example, venom of a pale toadstool).
Silymarin also enhances protein synthesis by stimulating RNA A polymerase (an enzyme located in the nucleus). This contributes to an increase in the formation of ribosomal RNA. As a result, protein synthesis (both functional and structural) is stimulated. Thus, silymarin helps to improve the regenerative ability and accelerate the regeneration of liver cells.
Capsules "Legalon" instructions for use recommends use for toxic lesions in the liver. The medicine is prescribed for cirrhosis or inflammation in the liver (as a maintenance drug).
The Legalon infusion solution is recommended for use in cases of poisonous poisonous grebe poisoning.
Capsules are prescribed to patients from the age of twelve. Dosage - 1 (one hundred and forty milligrams) or 2 (seventy milligrams) capsules three times a day. The duration of treatment is determined by the doctor individually.
The dose of Legalon solution is recommended for use according to weight. Twenty milligrams of medicine is prescribed per kilogram of weight. The resulting dosage is divided into four infusions. The duration of each infusion is at least two hours (taking into account the fluid balance in the body). With a mass of seventy kilograms per infusion, one bottle is required.
The contents of the bottle before infusion are dissolved in thirty-five milliliters of a solution of glucose (five percent) or sodium chloride (0.9%) and mixed with the solution for infusion.
The drug "Legalon" instruction recommends using after poisoning as soon as possible, even if the final diagnosis of intoxication with mushrooms is not precisely established.
Intravenous infusion is carried out for several days until the signs of poisoning are completely eliminated .
The drug "Legalon" instructions for use does not allow for use in case of increased individual sensitivity, acute poisoning of a different nature (except for those indicated in the annotation).
When using the medicine in rare cases, a hypersensitivity reaction may appear in the form of shortness of breath or rash. The drug "Legalon" (reviews and comments of doctors confirm this) is low toxic. In this regard, its prolonged use in therapeutic dosages is allowed. In some cases, the medicine may have a laxative effect. Some patients may experience a feeling of heat during the infusion.
special instructions
Capsules "Legalon" can be prescribed for the correction of lipid metabolism.
If jaundice occurs during treatment, consult a doctor. Probably, adjustment of the treatment regimen will be required.
Against the background of therapy, patients should undergo strict systematic control over the level of acid-base and electrolyte metabolism, as well as fluid balance.
Due to insufficient data, the use of the drug for children under twelve years of age is not recommended.
When using the drug "Legalon" cases of overdose are not registered. If a condition occurs (due to the fact that there is no specific antidote), symptomatic therapy is performed.