The drug "Sydnopharm" is an active peripheral agent that is able to expand the lumen of blood vessels and reduce pressure in them. Also, the medication helps to prevent and relieve angina attacks, is used to treat other symptoms of coronary insufficiency.
The principle of the drug
Sydnopharm is a donor of nitric oxide released by the drug during metabolic reactions. This binary compound stimulates the production of
soluble guanylate cyclase, the increased concentration of which leads to relaxation of smooth muscle tissue in the vessels. As a result, the load on their walls decreases, and as a result, the balance between oxygen demand and its entry into the blood is restored. Narrowed vessels that are capable of stretching expand under the influence of the Sidnofarm medication.
The drug also slows the release and synthesis of thromboxane and serotonin, which leads to the suppression of the early phase of aggregation of these enzymes and the prevention of blood coagulation.
pharmachologic effect
How does the Sidnofarm preparation biologically affect the human body? The instruction for use states that as a result of the use of this agent in the lateral (bypass) blood flow paths, blood circulation improves. Also, the medication increases the tolerance of loads and reduces the frequency of angina attacks that occur during physical efforts.
Among other things, the Sydnopharm drug narrows the chambers of the heart in case of heart failure in a chronic form, lowers the pressure in the arteries of the lungs. Due to this effect, the left ventricle of the main human organ is less filled with blood, and myocardial muscle tension decreases.
Duration of action of the drug
How quickly does the patient improve when he takes the Sidnofarm drug? Reviews of numerous patients and instructions for use indicate that it is well and quickly absorbed by the digestive system. The effect of the drug "Sydnopharm" can be noticed after 20 minutes from the moment of its use inside or after 5-10 minutes, if you put the pill under the tongue. The peak reaction of the body to the drug is observed between 30 and 60 minutes after taking it. The remedy is valid for 6 hours.
The Sydnopharm drug practically does not bind to plasma proteins. The metabolism of the drug occurs in the liver, and it is excreted to a greater extent through the kidneys. In the case of long-term therapy with this drug, resistance to it does not occur.
Sydnopharm tablets: indications for use
The drug is used in medicine in the following cases:
1. For stopping and preventing angina attacks.
2. With myocardial infarction at the stage of stabilization of hemodynamic parameters.
3. In case of insufficiency of the left ventricle of the heart in an acute form.
4. With increased pressure in the pulmonary circle of blood flow.
5. With heart failure in a chronic form.
In the latter case, there is one feature of the use of the drug "Sidnofarm." Indications for its use in this situation are diseases in which it is necessary to take more glycosides and diuretics in combination with the presented medicine.
Mode of application
In order to avoid complications and overdose, only the doctor should prescribe the Sydnopharm. Indications for use of this drug determine its use inside during or after eating. Drink the tablets with water in sufficient quantities.
In order to prevent angina attacks, Sydnopharm is prescribed 1-2 mg for 4 to 6 times during the first and second days of treatment, 2-4 mg for 2-3 times for every next day. Sometimes the dose rises to 6-8 mg or more, but the maximum is 12 mg.
The drug is dosed individually in each case. Its necessary amount for therapy depends on the stage and type of the disease, as well as on the symptoms. Depending on the course of the disease, the duration of the course of treatment is prescribed.
Side effects
Does the use of Sidnofarm tablets have negative consequences? Instructions for use of the drug informs that the tool can provoke the occurrence of a headache at the initial stage of its administration. After a short period of time, the sensation disappears.
Also, when using the drug "Sydnofarm" may lower blood pressure, sometimes to a state of collapse. Occasionally, motor and mental reactions slow down. When using this drug, it is necessary to consider the drivers of vehicles and people of other professions who require concentration and quick decisions in the workplace.
In addition, due to the use of Sidnofarm tablets (patient reviews confirm the data), side effects such as nausea, itching, dizziness, skin rash and other allergic reactions can be observed.
Contraindications
Pathologies in which the use of the drug "Sydnopharm" is contraindicated:
- acute stage of myocardial infarction;
- glaucoma (especially angle-closure);
- craniocerebral, arterial hypertension;
- collapse of blood vessels;
- circulatory disorders of the brain;
- pregnancy (first trimester) and lactation;
- advanced age ;
- individual intolerance to the drug.
Interaction with other drugs
Is it acceptable to use tablets with other medicines during therapy?
Sydnopharm? Instructions for use of the drug say that the drug can be simultaneously used with calcium antagonists and beta-adrenergic blockers.
When used for medicinal purposes, the medication "Sidnofarm" should completely exclude the ingress of alcohol into the body.
Features of the use of the drug
In what cases should I take the Sidnofarm medicine with extreme caution? The instructions for its use explain that you should be careful about unforeseen reactions of the body to the drug with impaired blood circulation of the brain, with increased intracranial pressure, with arterial hypotension, glaucoma, as well as after a hemorrhagic stroke or after myocardial infarction.
Patients in old age with kidney or liver failure should take Sidnofarm tablets in a minimal amount. Instructions for use of the drug also warns that the dye E110, which is contained in this drug, can cause allergic reactions.
During pregnancy, it is necessary to carefully analyze the risk ratio for the fetus and the benefits for the expectant mother before starting treatment with Sydnopharm. The use of the drug during lactation is strictly contraindicated. If the use of the medication is vital at this time, then breast-feeding must be stopped. Children and adolescents under the age of 18 are also prohibited from using this medication.
Overdose
What consequences can occur when Sydnopharm tablets are consumed in excessive quantities? First of all, this is fraught with a sharp decrease in blood pressure. This causes dizziness, nausea, and vomiting.
Treatment for an overdose depends on the symptoms. A prerequisite is measures aimed at speedy cleansing the body of the drug "Sidnofarm" - forced diuresis or gastric lavage.
Release form
The drug "Sydnofarm" is made in the form of tablets of 4 mg or 2 mg, as well as in the form of long-acting pills of 8 mg. The drug is packaged in blisters. Each of them contains 10 tablets. The plates are packed in boxes of cardboard, 3 pieces each (one package contains 30 pills).
Storage conditions
Sydnopharm tablets are potent medicines. They must be stored for no more than three years in cool, dry places inaccessible to children, at a temperature of 15 to 25 ° C.
Structure
The main active ingredient of the drug "Sidnofarm" is molsidomine. The auxiliary components of the drug include Avicel PH 101, peppermint oil, starch, hydroxypropyl methylcellulose, lactose, magnesium stearate, Aerosil 200, mannitol.
Analogs
Is it possible to replace Sidnofarm tablets with other drugs? Analogues of this drug exist. These include Dilacid, Corvamin, and Corvaton medicines. The characteristics of each of them are given below.
The drug "Dilasidom" ("Dilasidom") . It is made in Poland. Its active substance is, as in the "Sidnofarm" means, molsidomine (molsidomine). According to the anatomical-therapeutic-chemical (ATX) classification, the drug “Dilacid” refers to peripheral vasodilators used to treat heart diseases and antianginal drugs.
Means "Corvamin" ("Corvamin"). It is made in the Netherlands. The active ingredient of the drug is also molsidomine. According to the ATX classification, the drug "Corvamin" refers to antianginal drugs and peripheral vasodilators that are used in the treatment of heart disease.
The medicine "Corvaton" ("Corvaton"). It is made in Germany. Actively acting, the main substance of this tool is, like other analogues of the Sidnofarm tablets, molsidomine. According to the ATX classification, the drug “Corvaton” is included in the group of antianginal drugs and peripheral vasodilators, which are used to treat heart ailments.
Under no circumstances is it recommended to use Sidnofarm tablets or their analogues without the appointment of a doctor. Self-medication can lead to irreversible negative consequences. It is also strictly forbidden to change the dosage and duration of the course of therapy, according to one’s own feelings, without consulting a doctor.