Diseases associated with the circulatory system are one of the most dangerous ailments of our time. Their treatment requires a long and complex therapy, which includes maintaining a healthy lifestyle, following a diet and other recommendations of specialists.
In some cases, doctors prescribe Atoris, the official instructions for use of which will be discussed in this article. What is a similar remedy? What are its indications and side effects? How to take the drug to improve your health? You can find answers to these and many other questions in the instructions to Atoris. Price, analogues and patient reviews will also be presented.
Product Release Form
What is Atoris? The instructions for use explain that these are round white tablets coated with a special coating.
The most important thing is the composition
What the drug consists of is decisive in the matter of its purpose. If the patient has an individual intolerance to any substances, then you should carefully look at the composition.
The instruction to "Atoris" explains that the active substance of the drug is atorvastatin calcium. Depending on the form of release, the amount of active ingredient in each tablet may vary. For example, at the pharmacological market, the active substance - atorvastatin, is represented by such dosages: 10, 20, 30 and 40 mg. Instructions for use of Atoris and the price of the drug largely depend on the amount of the main component in the composition. And this is quite logical.
But still, general information and recommendations regarding the use of the drug are similar regardless of the dosage of its active substance. Therefore, below we will consider the general instructions for the use of Atoris. Price and analogues will also be indicated.
Excipients that make up each tablet are the following components:
- lactose monohydrate;
- microcrystalline cellulose;
- croscarmellose sodium;
- hyprolosis;
- polysorbate 80 ;
- crospovidone (type A);
- sodium hydroxide;
- magnesium stearate.
What is the film coating of tablets? It is also important to know, especially when it comes to the individual intolerance of any components. The composition of this shell includes polyvinyl alcohol, titanium dioxide, macrogol 300 and talc.
What effect does the drug have when it enters the human body? Annotation to Atoris answers this question in detail.
Pharmacological effects
In what cases is the drug prescribed? According to the recommendations of many experts, pills are taken to lower cholesterol. The instruction to “Atoris” explains this by the fact that the active substance of the drug is able to lower the activity of the enzyme that catalyzes the synthesis of mevalonic acid (this enzyme is called HMG-CoA reductase), due to this, the cholesterol compound is blocked and, accordingly, its amount in blood and plasma is reduced.
Since atorvastatin belongs to a group of statins, it binds to reductase receptors, affecting the metabolism of macrophages. Statins also have a positive effect on the walls of blood vessels, improve blood properties, and inhibit the oxidation of molecules.
According to experts, Atoris is used to treat homozygous familial hypercholesterolemia. Such a disease is not amenable to drug therapy with conventional lipid-lowering drugs. Therefore, in this case, Atoris is simply an indispensable tool. But what happens when a drug enters the human body?
Pharmacokinetic features of the drug
According to clinical studies, atorvastatin is absorbed quite quickly from the organs of the gastrointestinal tract. Two to five hours after the use of tablets, the highest concentration of the active substance in the blood plasma is achieved. The half-life of blood is 14 hours. However, the effect of statin on HMG-CoA reductase lasts much longer (about a day or more). A similar situation is explained by the participation of active metabolites in the process.
Atorvastatin is excreted from the body mainly by bile, only a small part of the substance is excreted by the kidneys (about 2%).
Although the bioavailability of the substance is quite low (not more than 12%), the binding to atorvastatin plasma proteins reaches 98, even 99%.
Eating slows the absorption of atorvastatin into the blood, but does not have a practical effect on its effectiveness.
And although it has already been mentioned above in what cases a drug is prescribed, let's find out more about it.
When take pills
The following is a list of diseases in which doctors prescribe Atoris:
- Hereditary hypercholesterolemia (including non-family and heterozygous familial).
- Hyperlipidemia (combined or mixed form).
- Dysbetalipoproteinemia (as an addition to following a special diet).
- Familial hypercholesterolemia of a homozygous form.
- Hypertriglyceridemia (endogenous family type), which cannot be corrected by a special diet.
Also, the drug can be prescribed as a prophylactic for cardiovascular complications to those patients who are at risk of developing coronary heart disease. Such people fell into the risk zone by several criteria at once (age over 60 years old, tobacco smoking, genetic predisposition, diseases - diabetes mellitus or arterial hypertension).
Atoris can also be recommended for patients with a history of coronary heart disease. In this case, the drug minimizes the possible complications of the disease, which can manifest as a stroke, myocardial infarction, severe angina pectoris and even death.
How to take the remedy. General information
Tablets should be taken orally, without chewing, with a glass of clean water. The use of the drug does not depend on meals. The main thing is to take pills at the same time for the period recommended by the attending physician. During the treatment period, it is very important to adhere to a strict diet prescribed by a specialist. It is then that the therapy will give positive and quick results.
How about the dosage?
This is the most important thing that interests many patients. How to take the drug so that the real benefits are visible?
It is worth mentioning that the annotation to the remedy, announced by the manufacturer, gives only general information about the regimen and dosage of atorvastatin. A more accurate appointment for the patient will be prescribed by the attending physician, taking into account the stage of the disease, testimony and well-being of the patient.
The initial daily dose of the drug is 10 mg. Instructions for use "Atoris" (the price of tablets will be indicated below) recommends sticking to this dosage for four weeks. If no improvement is observed, then the attending physician adjusts the required daily amount of atorvastatin in accordance with the clinical indications.
For example, the dosage may be increased to 40 mg. Instructions for the use of Atoris (we will also talk about the price of the drug) explains that the daily rate can be increased up to 80 milligrams. However, it should be remembered that this is the highest permissible dose of atorvastatin. Therefore, if treatment is not beneficial, then it is necessary to change the drug, and not increase the number of absorbed tablets.
Since the treatment with the drug is long, during the treatment period it is necessary to take a blood test to detect the level of lipids that are concentrated in the plasma. This is recommended to be done at least once a month. Sometimes doctors recommend having such an examination once every two weeks.
So, we discussed what ailments should take the pill, and also found out the approximate schedule and dosage of administration. Does the drug have contraindications and side effects? Of course, like all medications. Therefore, let's try to thoroughly understand this issue in order to avoid improper use of the product, as well as to be prepared for possible unpredictable reactions of the body to the active substance. In this we will be helped by instructions for the use of Atoris.
You take 20 or 40 milligrams of the drug per day - it doesn’t matter. The principle of action of atorvastatin is identical in both cases. Therefore, carefully read the annotation and follow the recommendation of a specialist to avoid all sorts of problems and complications.
When you can not use the tool
Particular contraindications to the use of the drug include diseases associated with a serious liver condition, especially during an exacerbation. First of all, it is cirrhosis, hepatitis and so on. Also, the use of Atoris is unsafe for patients suffering from renal and lactose deficiency, galactosemia, diseases associated with skeletal muscle tissue and malabsorption.
Children's age (up to 18 years) is also the reason for not prescribing, since there are no clinically confirmed data on the safety of atorvastatin for this age group.
For elderly patients, the drug is prescribed in usual doses, without the need for dosage adjustment only on the basis of old age.
You should also be aware that Atoris cannot be taken by people whose field of activity involves driving a car or other mechanisms. Also, the drug is contraindicated in patients suffering from alcohol addiction. The combined use of alcohol and atorvastatin can lead to extremely negative consequences.
And, of course, we should not forget about the possible individual intolerance to any components of the tablets. If the patient has a history of an allergic reaction to atorvastatin or any other components of the drug, then the drug is by no means prescribed.
Women and the Atoris Reception
Representatives of the weaker sex of reproductive age can use the drug as a treatment, only using effective contraceptive methods, when the probability of conception is reduced to zero. This is important, since tablets can have a negative effect on the fetus, provoking severe malformations in the development of the embryo.
Clinical studies of atorvastatin in breast milk have not been conducted. Based on this, women are not prescribed Atoris during lactation. If it is vital to undergo treatment with the drug, then breastfeeding is stopped.
Possible adverse reactions to the active substance
What do patients using the drug say in treatment? What difficulties and negative manifestations did they encounter while taking the pills?
First of all, according to the reviews of numerous patients, they were disturbed by unpleasant sensations from the nervous system, manifested by dizziness and insomnia.
Many patients also mention headaches, migraines, drowsiness, and depression caused by taking pills. Moreover, there have been cases (although very rarely) that taking the drug has caused nightmares, sensitivity disorders, memory loss, facial paralysis, neurotic conditions, and even loss of consciousness.
What else do patients complain about? Often, taking the drug provoked chest pains, palpitations, increased pressure, interruptions in the heart rhythm and the like. Symptoms of bronchitis or rhinitis, pneumonia, exacerbation of asthma, and even nosebleeds may also appear.
A negative reaction of the digestive system is manifested in nausea and heartburn, defecation disorders, abdominal pain and sensation of heartburn, loss (or, conversely, increased) appetite, flatulence, belching, vomiting, and so on. Moreover, taking the drug can cause the development of stomatitis and gastrointestinal ulcer, hepatitis, pancreatitis, glossitis and the like. Also (however, this happens extremely rarely) conditions can be complicated by rectal bleeding, bleached, tenesmus, etc.
Atoris can also have a negative effect on the musculoskeletal system. Some patients noted the presence of seizures of the lower extremities and swelling of the joints. According to various studies, prolonged use of the drug can provoke the development of serious ailments, such as arthritis, myositis, muscle hypertonicity, bursitis, myalgia and the like.
How does the drug affect the hematopoietic system? Very rare cases of manifestations of anemia, thrombocytopenia and lymphadenopathy due to the use of Atoris have been recorded.
According to patients, taking the drug may be accompanied by tinnitus, loss of taste, impaired vision and hearing. The development of such ailments as parosmia and glaucoma can also be triggered.
And what about the urogenital system? Treatment with the drug sometimes causes peripheral edema or provokes manifestations of urogenital infections. Sometimes unpleasant symptoms can occur, such as urinary incontinence (or, on the contrary, retention), decreased libido, vaginal bleeding, loss of potency, and the like.
Also, taking “Atoris” may be accompanied by such adverse reactions as weight gain, exacerbation of gout, itching and burning of the skin, rash on the body, eczema, facial swelling, seborrhea, dermatitis, etc. However, it is worth noting that such critical symptoms are extremely rare .
Therefore, tablets should be taken only according to the scheme established by the attending physician. Moreover, it is necessary to take laboratory tests every 0.5-1 month and, of course, visit a doctor. If there are any negative reactions, even the most minimal ones, it is recommended to inform the specialist about this.
Interaction of Atoris with other pharmacological agents
Can I take the drug with other drugs? Yes, in many cases, Atoris is prescribed as a complex treatment of a disease. However, this should be done selectively, paying attention to the manufacturer's recommendations listed below.
For example, co-administration of atorvastatin and digoxin may slightly increase the concentration of the latter in the blood.
Colestipol, on the other hand, has the property of reducing the amount of the active component of Atoris, while enhancing its hypolipidemic effect.
Substances such as verapamil, diltiazem, intraconazole and isradipine increase the concentration of atorvastatin, which can trigger the development of myopathy.
The parallel use of fibrates, cyclosporine or antifungal agents based on azole and nicotinic acid is also a provoking effect of the onset of myopathy. The risk of manifestation of this disease is detected against the background of the combined use of atorvastatin, erythromycin or clarithromycin.
Also, the main component of Atoris is a provocateur of increasing plasma concentrations of substances such as ethinyl estradiol and norethisterone (provided that the drugs are used concurrently).
Reviews about the drug
Many patients respond positively to Atoris tablets. They note that if it were not for the drug, then health would only worsen. Atorvastatin really lowers cholesterol, thins the blood, improves the general well-being of the patient. Many people have been taking the drug as prescribed by a doctor for several years, thereby fleeing from serious illnesses such as stroke, coronary heart disease and atherosclerosis.
And yet, not everyone is happy with the treatment. Firstly, many patients care about the cost of the drug. And although they don’t save on health, as we all know, I still would like the life-saving tool to be a little cheaper.
However, these are not all the negative comments of patients about Atoris tablets. Many admit that the tool simply did not fit them. Cholesterol did not decrease, which indicates that the drug is not effective in all cases, without exception. Moreover, some patients complain that, on the other hand, their cholesterol levels jumped while taking the medication. However, such cases are atypical and are extremely rare.
This is what people pay attention to quite often, so it is possible adverse reactions when taking the drug. Many have cramps, headaches, and other unpleasant symptoms. In many such cases, the attending physicians do not stop taking Atoris, but prescribe additional medications that help the body cope with side effects on its own.
In some cases, such a tool is a complex preparation based on magnesium and B vitamins. Thanks to its use, many side effects caused by Atoris treatment actually decrease and even pass. This helps patients continue to take a life-saving remedy for cholesterol.
Also, in their reviews, patients strongly advise not to prescribe the medicine on their own, but to strictly follow the instructions of a specialist.Moreover, many people suffering from high cholesterol urge not to rush with the use of such a serious tool as Atoris. Such patients recommend first to go on a rigid diet, which will be prescribed by the attending physician, and only then, if proper nutrition could not help, start taking pills.
On the other hand, many admit that they were able to normalize cholesterol precisely because of a correctly planned diet. Adhering to clinical nutrition, such people coped with the disease without medication. And it is commendable.
However, cure by diets is not always possible. Therefore, it is worth listening to not only the advice of experienced, but also the recommendations of the attending physician.
How much is the drug
So, we examined in detail the reviews and instructions for the use of Atoris tablets. The price of the drug is of interest to many.How much does a long-term treatment cost? It is not difficult to calculate, knowing its average cost.
As mentioned above, it all depends on the amount of active substance in the composition. So, the price of Atoris 40 (instructions for use has been disassembled above) varies from 520 to 650 rubles. The price is per pack of 30 tablets.
In general, the price of Atoris 40 (instructions for use and reviews of the drug read above) largely depends on the manufacturer and the pharmacy chain. The same can be said about other pharmacological medicines. As you can see, if we talk about the wrapping up of pharmaceutical companies, then the cost does not always depend on the amount of active substance indicated on the package and in the instructions for use.
Atoris 30 mg each costs an average of 500 to 550 rubles. And what about drugs with a lower dosage? For example, tablets, the amount of active substance in which, according to the instructions for use, is 20 mg? The price of Atoris with such a dosage ranges from 1000 to 1100 rubles. It is noteworthy that the cost is indicated for a package of 90 tablets.
If we are talking about a container of 30 pills, then the price varies from 490 to 540 rubles. It is clear that it is more profitable to purchase a package with a large number of tablets. The same principle applies to the drug with the smallest dosage of atorvastatin.
The price of Atoris 10 (instructions for use and reviews about the drug were examined in detail) varies between 550 and 650 rubles for 90 tablets and 330-400 rubles for 30 tablets. It is clear that for long-term treatment it is more profitable to buy a package with a large number of healing pills.
Analogs of means
And what about drug substitutes? To be brief, there are several. If you look for analogues of Atoris, according to the presence of the same active substance, then they are such medicines as Sinator, Atomax, Liprimar and Torvard. It is noteworthy that these drugs are almost identical to Atoris and have similar instructions for use.
And what about the agents having the same spectrum of action with Atoris, but differing in composition? There are a lot of these drugs. One of them is Cardiostatin. The active substance of this medication is lovastatin. The drug is prescribed for the treatment of primary as well as combined hypercholesterolemia, coronary atherosclerosis in the presence of coronary heart disease, as a therapy for combined hypertriglyceridemia. Take the drug should be 10-20 milligrams once a day, preferably in the evening. If we are talking about atherosclerosis, then the dosage of the drug increases to 20-40 milligrams per day. Every month, the daily rate should be adjusted in accordance with the testimony.
Rosuvastatin is another substitute for Atoris. Its active ingredient is rosuvastatin calcium. The drug is used to lower cholesterol in atherosclerosis and hypercholesterolemia, as well as a comprehensive treatment for stroke, arterial revascularization of myocardial infarction and other complications, especially if there is a risk of developing coronary heart disease. The drug is prescribed for 5 or 10 milligrams per day. In severe cases, the daily dosage is increased to 40 milligrams.
Simvastatin is a substitute for Atoris when it comes to elevated cholesterol. The active substance of the drug is simvastatin. Take the drug should be five, the maximum - 20 milligrams per day. "Simvastatin" has a large list of contraindications and side effects, as, in principle, other drugs of the statin group.
As you can see, there are many analogues of Atoris, similar in both the spectrum of the impact and the composition. Their price is very different. Some drugs are more expensive than the medication we are interested in, and some are several times cheaper. However, in no case do not assign them to yourself. No matter how well you study the instructions, the correct dosage and regimen can be recommended only by your doctor.
Only a specialist, on the basis of your clinical data, well-being and concomitant ailments, is able to prescribe the correct, appropriate therapy with one or another medication. Therefore, try to find a doctor that you will fully trust. If necessary, do not hesitate to consult another specialist. If you find someone you trust, then medication will definitely benefit you.
And, of course, when using drugs, do not forget about proper diet and moderate physical activity. In this case, the treatment will be more effective and faster.
We disassembled the instructions for the use of Atoris. Price, reviews and analogues were also presented in today's article. We hope the above information will be useful to you. Remember that any health problem needs to be treated, and not let everything go by its own accord. Diseases alone do not go away.