The drug "Cefotaxime" is an antibiotic that is a semi-synthetic representative of a number of cephalosporins. This substance has a wide spectrum of effects and is active in relation to both gram-negative and gram-positive bacteria. This tool is used if the pathogen is insensitive to penicillin antibiotics.
The drug "Cefotaxime" (antibiotic): description and properties
The active substance of the drug affects some enzymes of the pathogen, stopping the synthesis of the cell wall. As a result of such exposure, microorganisms lose their ability to reproduce.
The maximum concentration of the drug in human blood is observed five minutes after intravenous administration or 30 minutes after intramuscular injection. An effective concentration in the body persists for 12 hours, after which one more dose is needed.
Spreading together with blood, the substance easily and quickly penetrates into tissues and internal fluids. For example, its effective concentration is observed in skin tissues, myocardium, bones and gall bladder. The same picture is observed with fluids - the antibiotic accumulates in the pleural, synovial and spinal substance.
The drug is excreted mainly through urine, and in almost unchanged form. A small amount passes into breast milk and bile.
The drug "Cefotaxime" (antibiotic): indications for use
This medicine is used to treat infectious diseases that are caused by microorganisms that are sensitive to it. Most often these are diseases of the lower respiratory system, including abscesses, pneumonia, bronchitis and pleurisy. The drug is also effective in the treatment of diseases of the ENT organs (tonsillitis, otitis media), kidneys and urinary tract. Doctors prescribe this drug to patients with an infection of bone tissue and organs of the abdominal cavity.
In some cases, an antibiotic is used to treat a number of sexually transmitted diseases, including chlamydia and gonorrhea.
The drug can be used as a prophylactic against postoperative complications and relapses.
The drug "Cefotaxime" (antibiotic): use
This medicine is administered intramuscularly. But sometimes it is also advisable to administer intravenously through injection or with a dropper. The dose is determined only by the attending physician, based on the severity of the patient's condition. As a rule, the interval between repeated doses is from 6 to 12 hours.
The drug "Cefotaxime" (antibiotic): contraindications and adverse reactions
To begin with, it is worth noting that this tool can not be used to treat patients with hypersensitivity to penicillin or cephalosporin antibiotics. It is also contraindicated in bleeding or if there is a history of enterocolitis.
The medicine "Cefotaxime" during pregnancy or during lactation should not be taken. An exception may be only special cases. But for the duration of therapy, it is worth stopping breastfeeding, since the antibiotic is excreted along with milk.
If the sick person has any abnormalities in the functioning of the kidneys and liver, then use the antibiotic very carefully. In this case, the patient needs constant monitoring.
As for adverse reactions, the drug “Cefotaxime vial” causes them relatively rarely. But the risk of developing dysbiosis is quite high, so you need to take special medications to protect microflora. Vomiting, nausea, diarrhea and abdominal pain, headache, weakness may also occur. Sometimes allergy symptoms appear - skin rash, itching, erythema. In extremely rare cases, anaphylactic shock may occur .