"Trimetazidine" is a drug that helps normalize metabolism in cells undergoing ischemia or hypoxia. The agent is almost completely and relatively quickly absorbed. The bioavailability of the drug is about 90%. The concentration of the active substance in the blood reaches a maximum after two hours. Interaction products are excreted through the kidneys with urine.
Mechanism of action
The drug prevents a decrease in the intracellular level of ATP, ensures normal activity in membrane ion channels. The medicine also provides transmembrane transfer of sodium and potassium ions and the preservation of homeostasis. Means "Trimetazidine", the indications for use of which will be given below, slows down the process of oxidation of fatty acids. This ensures protection against ischemia. Switching oxidation to glucose from fatty acids determines the antianginal effect of the drug. During experiments on animals, it was found that the medication helps maintain energy metabolism in the neurosensory organs and heart during periods of ischemic exacerbations. Due to the activity of the drug, the value of intracellular acidosis and the level of changes in the transmembrane ion flow decrease. In addition, the drug reduces the infiltration and migration of polynuclear neutrophils in reperfusion and ischemic heart tissues, and reduces the size of myocardial injuries. At the same time, its effect on hemodynamics is not noted.
The medicine "Trimetazidine": indications
The drug should be prescribed by a specialist. It is highly recommended not to self-medicate. What pathologies can a doctor prescribe "Trimetazidine" for? Indications for use of this drug are as follows: cochleo-vestibular disorders of ischemic nature (dizziness, hearing impairment, tinnitus), vascular disorders of the chorioretinal type with an ischemic component. The medication is also prescribed to patients for the prevention of angina attacks (as a single drug or as part of combination therapy).
Dosage regimen
When prescribing Trimetazidine (indications for use are described in the article), the tolerance of the drug and the severity of the pathology are taken into account. As a rule, the medicine is taken at 40-60 mg per day. The frequency of administration is 2-3 r / day.
Contraindications, side effects of the drug "Trimetazidine". Patient Reviews
The drug is not recommended for pregnant and lactating patients with hypersensitivity to the components. Reviews of patients taking the drug are generally positive. According to patients, the drug "Trimetazidine", the indications for use of which were described above, rarely causes undesirable consequences. A common complication is an allergic reaction. As a rule, it occurs due to hypersensitivity. Experts recommend contacting a doctor if itching, rash, severe skin reactions and other negative consequences occur when taking the drug. It is highly recommended not to change the dosage of the drug yourself.