Dosage form
The drug is produced in 3 dosage forms - suspensions, dispersible and conventional tablets. Suspension of a pleasant smell, with a shade of yellow color and taste quite characteristic of this preparation. The suspension may redisperse by shaking the vial.
The tablets are available in almost white, with a slight yellowish tint. The tablets are round, biconvex, both of its surfaces are smooth.
Nise composition:
Suspension
Active substance
- Nimesulide - 50 mg (in 5 ml suspension)
Excipients:
- Sorbitol
- Glucose
- Xanthan gum
- Propylparaben
- Methylparaben
- Lemon acid
- Pineapple flavor
- Yellow dye WS
- Glycerol
- Polysorbate
- Purified water
Dispersible tablets
Active substance
- Nimesulide - 50 mg (in 1 tablet)
Excipients
- Aspartame
- Calcium phosphate
- Microcrystalline cellulose
- Carboxymethyl starch
- Corn starch
- Talc
- Magnesium stearate
- Colloidal silicon dioxide
- Pineapple flavor
Tablets
Active substance
- Nimesulide - 100 mg (in 1 tablet)
Excipients:
- Magnesium stearate
- Calcium Phosphate Hydrogen
- Microcrystalline cellulose
- Silicon Anhydrous Colloidal
- Corn starch
- Sodium Starch Glycolate
- Talc peeled
Pharmacological action of the drug
The pharmacological effect relates primarily to nise - tablets, the instruction contains data on all dosage forms. The drug is an NSAID containing a sulfonylide moiety in its structure. Nimesulide may be a COX-2 inhibitor, as a result of which it has anti-inflammatory and analgesic effects, in addition, the drug also has analgesic effects, but to a lesser extent.
The mechanism of action of the drug is associated with the suppression of prostaglandin synthesis in the area of inflammation, as well as the suppression of the formation of oxygen radicals and inhibition of the release of myeloperoxidase.
Pharmacokinetics
Nise is perfectly absorbed from the digestive tract, reaching its maximum in the blood after 2 hours. The drug is 99% bound to proteins.
The drug Nise - tablets, instructions for which are taken from official sources, are metabolized in the liver and excreted in the urine, with 98% of the dose being excreted within 24 hours.
Indications
- Rheumatic diseases that develop outside the joint capsule
- Osteoarthritis
- Inflammation and pain after surgery
- Pain caused by dysmenorrhea
- Fever and pain during acute inflammation in the upper respiratory tract
Side effects Nise
Tablets, the instructions for which are now given, can give side effects in various systems and organs:
Side effects of the drug, which are related to the digestive tract
- Nausea
- Heartburn
- Pain in the stomach
- Tarry stool
Side effects of the drug that relate to the central nervous system:
- Headaches
- Drowsiness
- Dizziness
Side effects of the drug, which relate to allergic reactions:
Other side effects:
- Fluid retention
- Oliguria
- Swelling
Nise contraindications
A list of contraindications is given, in which it is recommended to avoid taking the drug, and in case of urgent need, only after consulting a doctor.
- GI bleeding
- Renal failure
- Liver failure
- Pregnancy and lactation
- Gastrointestinal ulcer
Drug Interactions Nise
Tablets, the instructions for use which do not provide complete and exhaustive data on all drug drug interactions, read as follows: it is not recommended to use together with the following drugs - phenytoin, digoxin, any diuretics, lithium preparations, anticoagulants, antihypertensive drugs, other NSAIDs, methotrexate, cyclosporin .