Pyrazinamide tablets have a bactericidal or bacteriostatic anti-tuberculosis effect depending on the concentration. The activity of the drug is preserved only in an acidic environment (at pH from 5.6 and below). On
on the basis of taking the medicine, the development of resistance is possible, the probability of which decreases when using the medication with other
anti-tuberculosis drugs. The drug "Pyrazinamide" (instructions for use confirms this) is most effective for destructive tuberculosis, revealed for the first time, caseous-pneumonic type processes, tuberculoma, caseous lymphadenitis. The drug lowers the transport of urate and uric acid, can trigger hyperglycemia. The drug from the gastrointestinal tract is almost completely and quickly absorbed. With plasma proteins, the drug binds to 10-20%. After an hour or two, the maximum concentration of the agent is observed. The drug is well distributed in fluids and tissues, deposited in organs, including the lungs, liver, kidneys, as well as encapsulated areas of tuberculous lesions. The tool passes the BBB. Metabolism occurs in the liver.
Indications
The Pyrazinamide medication (expert reviews confirm this) is the first choice in the treatment of tuberculosis.
Dosage regimen
It was found that monotherapy with a drug is not effective enough. In this regard, the medicine "Pyrazinamide" application instruction recommends use in combination with other drugs with anti-tuberculosis activity. For adults, the dosage is 30-35 mg / kg once a day. For patients whose weight does not exceed fifty kilograms, the indicated dose is three tablets (1.5 g). With a mass of more than 50 kg, 4 tabs should be taken. (2 g). For children, the maximum dosage is 2 grams. The drug is taken with food. It is recommended to drink the medicine during breakfast.
Means "Pyrazinamide". Instructions for use. special instructions
The medication does not cause an overdose if the doctor prescribes it. When taking a large amount of medicine, negative consequences from the central nervous system are noted - dizziness, headaches and others. Disorder noted
liver activity,
dyspeptic symptoms are likely
. In case of poisoning, symptomatic treatment is indicated. Before and during the course of anti-tuberculosis therapy, patients after 60 years of age are monitored monthly for bilirubin, AST,
uric acid and ALT. With liver function disorders, drug withdrawal is necessary. In patients with diabetes, the likelihood of developing hypoglycemia increases. With the combined use of the medicine with the Rifampicin medication, hepatotoxicity may occur. With complex use with the drug "Probenecid", a decrease in excretion is likely and, as a result, increased toxicity. Cross-sensitivity may be noted with the drugs Isoniazid, Ethionamide, nicotinic acid and other agents having a similar chemical structure. The medicine "Pyrazinamide" (instructions for use confirms this) is suitable for five years. Store the drug in unopened packaging, in places protected from light.