Medication "Avodart" (analogues - means "Duprost", "Dutasteride") belongs to the group of drugs for the treatment of benign prostatic hyperplasia. Medications are 5 alpha reductase inhibitors. The active ingredient is dutasteride.
The drug "Avodart" instruction recommends to eliminate and prevent the progression of benign prostatic hyperplasia, relieve symptoms, reduce the size of the prostate. The medication helps to improve urination, reduces the risk of acute urinary retention, and prevents the need for surgical intervention. The medicine "Avodart" can be used in combination with alpha-1-blockers or as a single drug.
The medication is contraindicated in case of individual intolerance to dutasteride and other components, as well as other 5 alpha-reductase inhibitors. Means "Avodart" instruction prohibits children and women.
Taking the medication may be accompanied by some adverse reactions. The negative effects of Avodart include gynecomastia (enlargement and tenderness in the mammary glands), ejaculation disorder, decreased libido, and impotence.
In rare cases, allergic manifestations in the form of limited edema, itching, rashes, angioedema, urticaria can be observed.
The drug "Avodart" instruction recommends taking for at least six months, even if the therapeutic effect has come quickly enough from the start of use. Otherwise, it is very difficult to give an objective assessment of the effect of the drug.
The drug is allowed to be taken regardless of food.
The dose for adult men (including the elderly) is one capsule (500 mcg) once a day. Do not soften or chew the drug.
There is no need to adjust the dosage for impaired renal activity.
Caution in the appointment should be observed for patients with impaired hepatic activity, due to the fact that the active component is extensively metabolized in the liver.
In clinical practice, cases of drug overdose have not been described. Due to the fact that there is no specific antidote, in case of suspicion of taking an increased amount of Avodart medication, symptomatic and supportive therapy is performed.
The active component of dutasteride is absorbed into the skin. In this regard, children and women should avoid contact with capsules, the integrity of the shell of which is broken. In case of accidental contact, immediately flush skin area.
Before using the Avodart medication, men with benign prostatic hyperplasia must undergo a rectal examination of the state of the prostate gland.
Identification of a prostate-specific antigen is an integral element of a set of research measures aimed at detecting cancer in the prostate.
After a six-month treatment with Avodart, patients showed a decrease in serum prostate-specific antigen by 50% even in the presence of cancer in the prostate. After the drug is canceled, the indicator returns to its original level within six months.
The ratio of the concentration of free PSA to the total does not change even during treatment with the Avodart medication.
When conducting studies, it was found that combination therapy with the drug with alpha-blocker increases the risk of heart failure.
Medication Avodart does not affect the ability to drive vehicles or engage in any other potentially dangerous activity.