The drug "Nimesan" is popular in the drug market. It refers to non-steroidal anti-inflammatory drugs. The main active ingredient is nimesulide. This confirms the instructions for use for the Nimesan tablets. They have an analgesic effect, help with inflammation, as well as with elevated body temperature.
Dosage form and composition
The drug is released in the form of triangular tablets in a light yellow color. What are they made of? The composition of Nimesan tablets includes 100 mg of nimesulide, excipients: corn starch, lactose monohydrate, talc, crospovidone, propyl parahydroxybenzoate, magnesium stearate.
How to apply and in what dosages?
Taken orally after meals, fifty and one hundred mg twice a day. If there is chronic liver failure, then in a daily dose of one hundred mg. It is better to use the minimum dose, and reduce the course of treatment. Children over the age of 12 are prescribed a single dose at the rate of 1.5 mg / kg body weight, in the maximum daily dose of the drug - five mg / kg per day.
pharmachologic effect
As indicated by the instructions for use with Nimesan tablets, their structure contains a sulfanilamide group. It is believed that nimesulide is a selective cyclooxygenase inhibitor (COX-2). The drug has an anti-inflammatory, analgesic, as well as antipyretic effect. The mechanism of action of the drug "Nimesan" is associated with inhibition of prostaglandins. The synthesis of these prostaglandin substances is inhibited in the area of very severe inflammation, but this does not manifest itself on the mucous membranes of the kidneys and stomach, because mainly the second type of cyclooxygenases is inhibited.
In addition, it is worth paying attention that the mechanism of the anti-inflammatory effect of this medication is due to the ability to inhibit the formation of free oxygen radicals. However , this does not affect phagocytosis and hemostasis.
This confirms the instructions for use for the Nimesan tablets. The price interests many buyers. In pharmacies, the drug costs from 165 rubles.
Pharmacokinetics
When taken orally, the drug is well and rapidly absorbed from the digestive tract. The maximum concentration of the active substance in the blood is observed two hours after the first dose of the medication. In 99% it binds to proteins, and after a single dose of 100 mg, the substance is found in the tissues of the female genital organs. It is metabolized by the liver. The half-life of the drug from the blood is three hours. The active substance is excreted in the urine during the day.
Indications for use
Nimesan tablets (instructions for use confirm this) are prescribed in the following cases:
- various rheumatic diseases occurring outside the joints;
- osteoarthritis;
- acute inflammatory processes in the upper respiratory tract, accompanied by fever;
- severe pain during menstruation;
- inflammatory processes and pain that arose after surgical intervention.
Contraindications to the use of the drug
Contraindications to the use of this medication include:
- the formation of ulcers in the stomach and duodenum, in aggravated form;
- any degree of functional disorders of the liver;
- acute bleeding from the digestive tract;
- impaired renal function;
- lactation period;
- pregnancy;
- hypersensitivity to the active active substance of the drug - nimesulide and other NSAIDs.
All this is confirmed by the Nimesan tablets, instructions for use and reviews. Dosage and method of application:
- The maximum allowable daily dose of the drug for adults is 400 mg (that is, four tablets of 100 mg), for children - 5 mg per day per 1 kg of weight. Adults are prescribed to drink tablets of 100-200 mg, washed down with plenty of water, twice a day after meals. Children are prescribed 1.5 mg per 1 kg of weight, also washed down with water, two or three times a day after meals.
Side effects when taking
As a rule, Nimesan tablets (there are instructions for use in each pack) are well tolerated by the body, but sometimes they still cause some side effects. These include:
- stomach pain, nausea, heartburn, in rare cases, stool is disturbed;
- dizziness, headaches, drowsiness;
- erythema, skin rash, urticaria;
- very rarely - fluid retention in the body, oliguria, systemic or local edema.
Reviews about the tablets Shreya "Nimesan" consider below. Drug interaction: you should be especially careful during the simultaneous use of the drug with phenytoin, digoxin, lithium preparations, and other NSAIDs.
special instructions
The drug "Nimesan" must be taken with caution in patients with renal failure, heart problems, and visual impairment. During external use, specialist supervision of elderly patients with renal, hepatic or heart failure is necessary. For children, special dosage forms should be used.
Due to the fact that the use of the drug can cause drowsiness and dizziness, patients who engage in hazardous activities, where a high concentration of attention and quick psychomotor reactions are required, should be especially careful. This is confirmed by the reviews of doctors to the analgesic "Nimesan".
Use by pregnant women
The drug is strictly contraindicated for use during pregnancy and during breastfeeding.
Interaction
The simultaneous use of Nimesan with drugs that reduce blood coagulation enhances this effect. Nimesulide may decrease the effect of furosemide. The therapeutic effect of antihypertensive drugs is reduced. The possibility of side effects with the use of methotrexate increases. Lithium and nimesulide simultaneously increase the level of the first in blood plasma. Nimesulide enhances the effect of cyclosporine on the kidneys. Glucocorticosteroids, serotonin reuptake inhibitors increase the risk of bleeding from the digestive tract. In general, any drug must be combined with another very carefully, this should only be done under the supervision of a physician.
Analogs of "Nimesana"
The following drugs are referred to analogues: Nimesulide, Nimulide, Nise, Nemuleks, Nimika, Nimesil, Aponil, Nimesulide-TEVA. Analogs can be cheaper or more expensive, it all depends on the manufacturer.
Reviews about the drug
In general, consumers note that the Nimesan drug quickly relieves pain, lasts for five hours, has a convenient form of release in the form of tablets and a nice price. But it also has a large number of contraindications and adverse reactions, which, fortunately, are rarely observed. Reviews of doctors about him are only positive. The tool effectively reduces body temperature, relieves even severe pain.