Chronic heart failure is a serious problem for both elderly and young patients. Supportive therapy is of great importance. The patient should regularly take pills to lead a normal lifestyle. A qualified cardiologist should prescribe the drug. Nitrosorbide tablets are popular among experts. Analogs are used less frequently.
Release form and composition
Tablets belong to the group of antianginal drugs. The main active ingredient is isosorbide dinitrate. As auxiliary substances, magnesium stearate, lactose monohydrate, polyvinyl acetate and talc are used. The tablets are available in white, have a round shape.
The main active ingredient, which is organic nitrate, helps to relax smooth muscle walls of blood vessels. The effect is not only on the arteries, but also on the veins. Deposition of venous blood is significantly reduced, venous return to the heart is reduced. Isosorbide dinitrate has a good clinical effect. Instructions for use states that the main component is rapidly absorbed into the blood. Due to this, the therapeutic effect occurs quickly and is long-lasting.
Pharmacokinetics
After entering the stomach, the tablets dissolve within a few minutes. For several hours, you can already notice the first results of therapy. The tablets are rapidly absorbed. The primary bioavailability of the drug is 22%. The maximum effect is achieved 2 hours after taking the pill inside. The main active ingredient binds to blood proteins by 30%.
The medicine is completely removed from the body after 12 hours. There is no cumulative effect. Metabolized by isosorbide dinitrate in the liver. In this case, the active metabolite isosorbide mononitrate is formed. The drug is almost completely excreted with urine.
Indications
Only a qualified cardiologist can be prescribed Nitrosorbide tablets. Analogs are also prescribed by the indications specialist. The drug can be used for coronary heart disease, if long-term treatment with other medicines did not give a positive result. Pills can prevent angina attacks.
As part of combination therapy, the drug Nitrosorbide may also be prescribed. Analogs can be used such: "Cardiket", "Iz Mik", "Dikor Long". These drugs will be described a bit below. Tablets may be used in conjunction with cardiac glycosides, diuretics, or inhibitors.
What else do Nitrosorbide tablets have? The medicine also helps with myocardial infarction. The medication is prescribed after a seizure as a prophylaxis. As part of combination therapy, the medicine can also be used to prevent angina pectoris. Tablets in this case have a prolonged effect.
Treatment with Nitrorbide is possible during pregnancy and lactation. However, use the medication with caution. The medicine is prescribed only if the potential benefit to the mother exceeds the possible harm to the baby.
Contraindications
The medicine is dispensed only by prescription. This avoids the misuse of tablets by patients. The fact is that the drug "Nitrosorbide", like "Cardicet Retard", has some contraindications. In no case should you use the medicine during acute myocardial infarction, if severe arterial hypotension is observed. In this case, the tablets may give the opposite effect. No medication is also prescribed for angle-closure glaucoma, hypovolemia, acute vascular insufficiency. The medicine is not taken for traumatic brain injuries.
There are also age restrictions. Nitrosorbide or Cardicet Retard tablets may be prescribed only to adult patients. Some patients may experience increased sensitivity to nitrates. If you have any allergic reactions, you should immediately stop taking the medicine and seek the advice of a cardiologist.
special instructions
Nitrosorbide tablets cannot be used to relieve angina attacks. The same can be said about Izo Mik, Cardiket, and Dikor Long medicines. All these drugs can be used only for prevention. If an attack is inevitable, other drugs will be required. During the use of Nitrosorbide tablets, it is necessary to regularly monitor the heart rate, as well as blood pressure. Patients with chronic heart failure should preferably be treated in a hospital setting.
Abruptly discontinue the drug is not recommended. Taking "Nitrosorbide" at the beginning of therapy can increase the number of angina attacks. The same effect can also be observed with a sharp withdrawal of the drug. For the relief of seizures during the treatment period, fast-acting nitrates can be used, which should be prescribed by a cardiologist. Self-medication can give unpredictable results.
Do not drive a vehicle if you need to use a drug containing isosorbide dinitrate. Instructions for use states that this substance can cause drowsiness and dizziness. It is not recommended to manage any complex mechanisms during the treatment period.
Dosage
Tablets have a prolonged effect. Patients with heart failure are prescribed 20 mg once a day. Gradually, the dosage increases. The maximum rate should not exceed 3 tablets per day. In more complex cases, sustained-release agents (40 mg each) can be prescribed. Patients take half a tablet twice a day. The dosage is increased with caution and only under the supervision of a doctor.
Treatment begins with minimal doses and gradually increase the rate to the most effective. Intended for long-term use of tablets "Nitrosorbid". Analogs are also intended for long-term therapy. Stopping treatment abruptly is not recommended. Side effects may develop.
Overdose
Strictly on the recommendation of a doctor, it is necessary to use Nitrosorbide tablets. Reviews show that an overdose can provoke the development of side effects. They appear more often in the form of dizziness, nausea, vomiting. Less likely to occur skin reactions, such as itching, rashes. On the part of the cardiovascular system, the patient can feel a significant decrease in blood pressure, heart palpitations.
Overdose treatment can only be carried out in a hospital setting. First of all, gastric lavage is performed. In the future, symptomatic therapy is prescribed. To stabilize the patient faster, activated charcoal can be used.
Side effects
With the right use of tablets, side effects can also develop. In most cases, they are only temporary and do not require withdrawal of treatment. Unpleasant symptoms at the beginning of therapy can also be caused by the tablets “Dikor Lorg”, “Izo Mik”, “Cardiket”. Initially, patients may experience a headache that is not eliminated by any medication and goes away by itself a few days after the start of therapy. Tachycardia, a decrease in blood pressure can also be observed.
From the digestive system, side effects are manifested in the form of nausea, abdominal pain, diarrhea. If vomiting occurs, you should immediately consult a doctor for advice.
Drug interaction
Caution should be taken with Nitrosorbide tablets with any vasodilator drugs. Such an interaction can lead to the development of side effects. With dihydroergotamine tablets can be used only after consulting a doctor. The interaction of drugs can lead to an increase in the concentration of dihydroergotamine in the blood and an increase in its hypotensive effect.
The joint use of acetylsalicylic acid with nitrosorbide tablets helps to improve blood circulation. Together with adsorbents, it is not recommended to use the drug. Such an interaction will lead to a decrease in the bioavailability of the drug.
Analogs
Nitrosorbide tablets are popular among experts. The price of the drug is low, and it differs in a positive effect on the body. But it is not always possible to find a medicine in a pharmacy. A cardiologist will always help to choose high-quality analogues. Cardicet tablets also do an excellent job. The main active ingredient of the drug is the same isosorbide dinitrate. The medicine is prescribed for the prevention of angina pectoris, as well as myocardial infarction.
More expensive counterparts are tablets "Dikor Long". As auxiliary components in tablets, corn starch, lactose monohydrate, colloidal silicon dioxide, magnesium stearate, titanium dioxide are used. Tablets can be prescribed for children, as well as for pregnant women in a hospital setting.
Izo Mik tablets are another popular remedy that can replace the Nitrosordide medicine. The main active ingredient is also isosorbide dinitrate. Of all the medicines listed, this is the most expensive.
Reviews about the tablets "Nitrosorbid"
The drug has a good effect on the cardiovascular system. In moderate heart failure, Nitrosorbide tablets are primarily prescribed. The price of the medicine pleases patients. One package can be purchased for just 15 rubles. Negative reviews may be associated with side effects that occur at the beginning of therapy. It is worth remembering that they are only temporary.
The medicine is not recommended to be used alone. Treatment should take place strictly under the supervision of a specialist who will determine the correct dosage in each case. It is also not necessary to abruptly cancel therapy.