Stress is an unusual reaction of the human body to the influence of external conditions, both positive and negative. Nowadays, everyone is stressed, causing devastating damage to health. Of course, it is very difficult to get rid of the influence of external factors, but Cavinton will help to overcome them without harm to health.
Release form and composition
The medicine "Cavinton" is prescribed primarily for disorders of the nervous system, as well as to stabilize the blood circulation.
The drug is produced in the form of concentrates and tablets based on the active component of plant origin - vinpocetine, which is synthesized artificially. This substance acts as an analogue of the natural component - devincan, which can be found in the flowers of periwinkle. A unique flower with which people learned to get rid of various spasms.
Later, drugs were already created that could lower blood pressure. By the way, lowering blood pressure, the drugs had a sedative property. After a while, we were able to track the beneficial effect of the drug on blood circulation in the vessels of the brain, and here the production of Cavinton has already begun.
Externally, the tablets are white, odorless, round in shape. A dividing risk runs through the center, and CAVINTON is engraved on the other side. There are two blisters in the package, each of 25 tablets. The composition of 1 tablet includes the following substances: 5 mg of vinpocetine, lactose monohydrate - 140 mg, corn starch - 96.25 mg, magnesium stearate - 2.5 mg, silicon dioxide - 1.25, talc.
In cases of complete intolerance to lactose deficiency, a medicine is prescribed in another form of release - a concentrate for the preparation of a solution for infusion. In one package, based on the instructions for use of "Cavinton", 10 ampoules - each with a volume of 2 ml. The solution is clear, colorless or a slight greenish tint may be tolerated. Ampoules are made of dark glass. 1 ml contains: 5 mg of vinpocetine, 0.5 mg of ascorbic acid, 1 mg of sodium disulfite, 10 mg of tartaric acid, 10 mg of benzyl alcohol, 80 mg of sorbitol and up to 1 ml of water for injection.
It is also worth noting the Cavinton Forte, which is identical in composition to the Cavinton analogue. The only differences are that the number of tablets in the package is increased to 30 or 90 pieces, and the dosage of vinpocetine is twice as much. The Cavinton instruction (10 mg) for use confirms that a single dose of the active substance contains only 1 tablet. The rest of the basic composition is unchanged.
Indications for use
Like any medicine, Cavinton should be used by the patient only if there are appropriate symptoms for its use and only after confirmation by a specialist. The drug is taken in various fields of medicine:
- Neurology - with the manifestation of autonomic menopause, with neurological and mental disorders (impaired memory and speech, various motor disorders, dizziness), during acute and chronic circulatory failure (ischemia, stroke, atherosclerosis, cognitive impairment, vertebro-basilar insufficiency).
- Ophthalmology - glaucoma (post-traumatic, post-inflammatory, post-thrombotic), various disorders of the retina, in the vessels and the macula, as well as various visual disorders that are caused by atherosclerosis, embolism, angiospasm or thrombosis.
- Otolaryngology - Meniere's syndrome (a disease of the inner ear, due to which the volume of fluid in the cavity increases), tinnitus, hearing loss (senile), neuritis, hearing loss due to vascular disorders caused by medication and others.
Contraindications
There are a number of contraindications of a pathological and physiological nature, which include:
- severe forms of arrhythmia;
- severe course of coronary disease caused by impaired blood flow in the heart muscle;
- hemorrhage stroke;
- hypersensitivity to the active substance of the drug or auxiliary components of the composition;
- malabsorption of lactose;
- during lactation and pregnancy (at any time);
- patients under 18 years old.
Before starting a course of therapy with this medication, it is necessary to make sure that the listed contraindications are absent.
Instructions for use "Cavinton"
Dosage is prescribed only by a qualified specialist after an examination and identification of the reasons for the indication of the drug. A single algorithm for the instructions for use does not exist, since each of the diseases has its own specifics. Only a doctor can determine the course of treatment and dosage. But, like any medicine has its own basic instruction, so does Cavinton, depending on the form of release.
Tablets are prescribed orally after a meal of 5-10 mg 3 times a day (minimum daily dose - 15 mg, maximum - 30 mg). Usually, a course is prescribed for a period of 1 to 3 months. If there are complications, then the course can be increased up to 8 months - this is what the instructions for use of Cavinton say . Reviews on the use of the drug confirm that after a week, patients experience a positive effect from its effect.
For some reason, the patient may be prescribed an infusion. It is worth considering that the solution has a completely different dosage. Before use, the medicine must be diluted with a physical or glucose solution (20 mg of the drug per 500-1000 ml of solution), which can be used for 3 hours.
Instructions for use of Cavinton contain such explanations : injections are administered intravenously, drip and not quickly (the maximum speed can be 80 drops per minute). The daily (average) dose is 35 mg per 60 kg of body weight. The maximum volume of the drug is up to 1 mg per 1 kg. The duration of the course is prescribed from 10 days to 3 weeks, depending on the severity of the disease.
Please note that in the instructions for use of tablets "Cavinton" there is a warning about a gradual decrease in dosage by the time the treatment is completed in 3 days. If the course was carried out with a solution, then in addition to reducing the dosage of injections, a further transition to the tablet form of the drug is necessary - 3 times a day, 10 mg each.
As for the instructions for use of the Cavinton Forte analogue, it describes the same mechanism: after eating, orally. The duration and dosage of treatment is prescribed only by a doctor. Be sure to start with 15 mg - a daily dose, then increase to a maximum of 30 mg per day.
Note: the prefix in the name of the drug only focuses on its modernization. The rest of the instructions for use "Cavinton Forte" is similar to the analogue up to side effects and storage conditions.
Side effects
The use of "Cavinton", judging by the instructions, in rare cases, but still can cause negative reactions of the body, such as:
- dry mouth, nausea, and heartburn;
- sleep disturbance - excessive drowsiness or, conversely, insomnia;
- weakness, dizziness, headache;
- various allergic reactions: rash, itching, urticaria, redness of the skin;
- inflammation of the veins (phlebitis);
- heart contraction (tachycardia);
- arterial hypotension.
Despite all the instructions described in the instructions for use, reviews of Cavinton confirm that the occurrence of Quincke's edema (enlargement of the face or its parts and limbs) and even anaphylactic shock are possible. Some patients have confirmed increased sweating.
In the event of the listed symptoms or others, you should consult a doctor for a reduction in the dosage of the drug or for the complete abolition of the course of therapy.
pharmachologic effect
Consider the pharmacodynamics of the drug. In accordance with the instructions for use of Cavinton, the active substance is vinpocetine, which has a complex effect on the body, normalizing brain metabolism and blood circulation.
The medication reduces the severity of the cytotoxic damaging reaction caused by stimulating amino acids, and thereby will achieve a neuroprotective effect. This leads to the fact that the brain tissue begins to consume more oxygen and glucose.
It blocks hypoxia by increasing the stability of neurons. At the same time, the levels of AMP and cGMP increase. Also in the brain tissue is an increase in the concentration of ATP and the ratio of ATP to AMP. Reduces the process of gluing cells together, increasing blood viscosity. The action of adenosine is enhanced, and the deformation ability of red blood cells increases, utilization of adenosine is blocked. In this case, the exchange between serotonin and norepinephrine increases.
Indicators of systemic circulation remain stable, despite an increase in blood flow (cerebral) and a decrease in the resistance of brain vessels.
What is the pharmacokinetics?
The drug is rapidly absorbed: within 1 hour after ingestion of the pill, the maximum concentration in the blood is reached. The process of absorption occurs in the gastrointestinal tract. Does not cause metabolic disorders when moving along the intestines.
At the maximum dosage, concentration is achieved 2-4 hours after administration. A linear character occurs with repeated doses of the drug in doses of 5-10 mg. Withdrawal of the drug from the body occurs in 4.83 ± 1.29 hours, through feces and urine in a ratio of 2: 3.
Analogs
Vinpocetine improves blood circulation in the human brain, as stated in the instructions to "Cavinton". The use of analogues of the drug is not forbidden, the main thing is the presence of the active substance in the composition. For instance:
- “Vinpocetine” - in addition to improving the metabolism and blood circulation in the brain, it reduces platelet adhesion and carries out oxygen transportation. Release form: tablets, solution for injections.
- "Bravinton" - an improvement in metabolic processes in the brain, while it has an antispasmodic effect. The drug can be used against frequent dizziness, with headaches and memory impairment. Release form: tablets, solution for injections.
- "Corsavin" - improves blood flow and cerebral circulation, dilates and relaxes the blood vessels of the brain, reducing the risk of ischemia and stroke. Release form: tablets.
- "Cinnarizine" - used for tinnitus, dizziness, nausea, vomiting and labyrinthine disorders. Release form: tablets.
- “Actovegin” - stimulates the regeneration process, transports and stores glucose and oxygen, improves the metabolic process and trophics. Release form: tablets, solution for injections.
- Mexidol is a domestic remedy for improving blood circulation in the brain. Release form: tablets, solution for injections.
Of course, the original gained its fame due to the high degree of purification during the production period. However, having studied the instructions for use of Cavinton Forte, we can say that this is an identical version of the original. The difference between them is only in the amount of active substance.
It is also worth paying attention to Cavinton Comfort, the instructions for use of which immediately informs about the main difference and advantage of the analogue: the dispersible property of tablets, that is, the ability to dissolve in saliva and water. In other words, if the patient has a violation of swallowing function, then this analogue will be prescribed to him.
If, for any reason, a course of taking one of the Cavinton analogues is ahead, the instructions for use are very similar in nature, then you should definitely consult a doctor. Only a specialist will be able to comprehensively consider individually all the positive and negative points for your body during therapy with this drug.
special instructions
Drug contents include lactose. It should be taken into account with intolerance to the substance that 1 tablet contains 41.5 mg of lactose.
Also, in case of lactose intolerance, you should avoid taking the active substance - vinpocetine.
It does not affect the functioning of the kidneys. Administration of the drug for renal diseases is carried out in standard doses, allowing long-term courses of therapy.
Does not affect liver function. Taking the drug for liver diseases is carried out in standard doses, allowing long-term courses of therapy.
ECG monitoring is necessary in the presence of a prolonged QT interval syndrome and an increase in its interval.
The medication has no effect on driving a car, as well as on the management of various mechanisms.
Drug exposure
The simultaneous use of the drug with a drug with antihypertensive effect , "Methyldopa" can lead to an increase in lowering blood pressure (BP). With this combination of drugs, it is necessary to control blood pressure.
With the simultaneous use of the drug with beta-blockers, no interactions are observed.
Although there is no evidence of any interaction potential, it is recommended that Cavinton be taken with extreme caution in conjunction with drugs that have effects on the central nervous system and with antiarrhythmics.
Overdose
A lot of data has been collected about an overdose of tablets. In case of exceeding the maximum daily dose in therapeutic treatment, it is necessary to wash the stomach and intestines. After it is necessary to take intestinal sorbents, for example, activated carbon and so on.
Conditions and shelf life of the drug
The drug, regardless of the form of release (solution, tablets), must be stored in a place protected from sunlight, and also inaccessible to children. In this case, the storage temperature of the drug is from 15 to 30 degrees.
Shelf life - 5 years from the date of manufacture. Such information is indicated on the packaging of the drug.
Reviews
After examining the reviews about the drug "Cavinton", we can conclude that patients really confirm the result, which is declared by the manufacturer. In many patients, after the course, headaches of a constant nature disappear due to narrowing of blood vessels. Tinnitus, dizziness and blurred vision also recede, and the result is noticeable after two weeks of administration.
There are also good reviews about Cavinton's analogues, the instructions for use of which only confirm that the similarity of the preparations is based on the main active substance of the composition - vinpocetine. It is he who, by his influence, helps to restore metabolic processes in parts of the human brain after ischemia.
The most famous analogues of the drug include Cavinton Forte and Cavinton Comfort. They are also not deprived of reviews, which once again confirm the effectiveness of the drug. Many diabetics confirm the safety of the drug and its analogues, regardless of the form of release (tablets / solutions).
Despite the fact that under the conditions of dispensing from pharmacies, “prescription” is indicated in the instructions for use of “Cavinton Forte”, the reviews confirm the opposite, and the doctors themselves say that the sale of the drug is possible without prescription, but do not neglect the prescription of the doctor. Still, the drug has, in addition to indications for use, a number of contraindications that can give the opposite result.
Patients themselves admit their mistake with uncontrolled self-therapy. For example, about neglecting the instructions for use of Cavinton Comfort, the reviews confirmed the occurrence of side effects and not only. Sudden abortions were observed due to the high concentration of the drug in the womb. Some patients, without giving the necessary information about the presence of lactose in the drug, earned flatulence. There have been cases when the human body showed an allergic reaction in the form of Quincke's edema. And with a combination of an unstable nervous system and hypotension, drug therapy gives a severe pressure drop.
So, to be healthy is the most cherished desire, perhaps, of every person. And for this it is necessary to maintain our blood circulation in the brain. The drug "Cavinton" and its analogues will help everyone in need of protection for their fragile vessels. But it is worth remembering that the uncontrolled use of any drug can only aggravate the condition of the body. Only a doctor will be able to comprehensively approach the development of an individual treatment program, as well as prescribe the dosage and mechanism for taking the vasodilator drug Cavinton.