In this article, we consider the instructions for use for the Trental preparation.
This medicine serves as a vasodilating agent, with which you can improve blood circulation, and, in addition, restore its fluidity. It can improve circulation directly in the area in which circulatory disorders are present. The active component of the drug affects the deformed red blood cells and helps to inhibit platelet aggregation. This happens in parallel with the process of expansion of the coronary vessels. Trental can only be prescribed by a doctor after carrying out certain diagnostic procedures. It is necessary to correctly calculate the dosage of the drug, as well as eliminate possible contraindications. The use of a qualified approach to treatment makes it possible to restore cerebral circulation. Instructions for use with Trental are presented below.
pharmachologic effect
The effect of the drug is that it improves blood microcirculation, providing an angioprotective effect. Systemic use of the drug can improve blood rheology. As a result of these processes, saturation of the soft tissue of the body with oxygen is observed.
Pharmacokinetics of the drug
According to the instructions for use, Trental is a drug that is known to the world under the name Pentoxifylline, which in turn is considered to be a derivative of Methylxanthin. "Pentoxifylline" does not allow platelets to aggregate, increasing their flexible state and reducing excessive plasma fibrinogen content. In addition, the drug increases fibrinolysis, leading to a decrease in blood viscosity. In addition, Pentoxifylline can dilate blood vessels, supplying all tissues with oxygen, especially the nervous system with the kidneys. In addition, this drug sufficiently increases the volume of coronary vessels. What else does the instruction for use with Trental 100 mg tablets tell us?
After using one tablet inside, the active substance moves first to the patient’s liver. Just there, the medicine forms a series of pharmacologically active metabolites. As a rule, metabolites-I and metabolites-V are formed there. The total accumulation of these metabolites in the blood can exceed the content of "Pentoxifylline" from about five to seven times. After a person takes the drug, the metabolites reach their maximum accumulation point after two hours. Trental is almost completely eliminated from the patient's body through the work of the kidneys. The remainder of the substances leaves the human body with feces.
Indications for use
In accordance with the instructions for use with Trental, the following conditions and pathologies appear as absolute indications for the use of this drug:
- The presence of encephalopathy and ischemic stroke.
- The presence of various disorders in the blood circulation.
- The presence of angioneuropathy.
- The appearance of gangrene, trophic ulcers and frostbite.
- The presence of vascular and retinal lesions.
- Failure of metabolic processes in the region of the inner ear.
- The development of respiratory diseases.
- The development of vascular impotence.
This describes the instructions for use with Trental 400 mg. The active ingredient that is part of this drug can reduce the likelihood of thrombosis, as it acts in a way that prevents platelet adhesion. This improves blood circulation in the region of small blood vessels. In addition, Trental reduces the amount of fibrogens that affect blood viscosity, which in turn allows you to improve red blood cell membranes, and, in addition, significantly increases their resistance. Instructions for use with Trental analogues will not be presented.
The active component of the drug also has a relaxing function, which has a positive effect on any vascular wall. All these processes lead to an increase in the amount of blood that enters the organs. The achievement of the therapeutic effect can be observed an hour after taking this drug. The process of neutralizing the active substance is carried out in the region of the liver, and its residues are excreted through urinary function. It should be noted that the decay products of the presented drug can also fully induce a positive therapeutic effect.
This is confirmed by the instructions for use. Reviews on Trental 100 mg are abundant.
The form of release of the drug and its composition
The drug is available in the following forms:
- In the form of tablets, the product contains at least 100 milligrams of the active ingredient - pentoxifylline.
- The concentrate for the preparation of the solution contains no more than 20 milligrams of pentoxifylline.
- One capsule of a drug contains 400 milligrams of the active substance.
As auxiliary components, Trental tablets contain sodium hydroxyl along with starch, magnesium stearate and lactose.
According to the instructions for use with Trental for droppers, the concentrate, in addition to the active component, contains sodium chloride. The composition of the capsules includes povidone and hyetellose with talc. Auxiliary components can cause adverse reactions during treatment. In this regard, it is very important to consult a doctor first, who must take into account intolerance to the body, and then select the most safe, and at the same time effective dosage.
Instructions for use with Trental 100 mg
The benefit of the drug presented will be maximal provided that the dosage is correctly prescribed and there are no contraindications to use. For each case, an individual dosage of the drug is needed.
The standard treatment regimen involves the use of Trental in two to four tablets at least twice a day. The medicine should be taken every day after eating. It is necessary to drink plenty of water. The maximum daily norm cannot exceed 1200 milligrams.
What does the instruction for use with Trental indicate? He is prescribed intravenously quite often. Good tolerance is observed with this method of administration. Dosage in this case directly depends on the severity of the pathological processes, and, in addition, on the general tolerance of the drug along with the individual weight characteristics of the patient.
Recommendations for the use of the drug
In relation to the drug "Trental" there are special recommendations regarding its use:
- In the presence of reduced pressure and against the background of impaired renal function, a low dosage of Trental is prescribed, which is gradually increased.
- Intravenous injections are used only in special cases in which 5 milliliters of the drug is administered.
- In the presence of liver failure, the dosage of the drug is selected individually.
- In the presence of a pronounced form of cardiac arrhythmias, careful monitoring is necessary.
- With the development of a severe form of coronary heart disease, and, in addition, with cerebral stenosis, therapy begins with small dosages with a subsequent increase.
Side effects of use
According to the instructions for use and reviews of Trental, the occurrence of an adverse reaction is characteristic of any form of this drug. Against the background of high speed intravenous administration or in the case of the use of large doses, there is a possibility of the following undesirable effects:
- Violation of the nervous system, which will be accompanied by a headache. Also, convulsions, dizziness and irritability are not excluded.
- Observation of allergic manifestations on the skin in the form of edema along with flushing and flushing.
- Violation of the digestive system. In this condition, the development of intestinal atony, xerostomia and anorexia including is characteristic.
- Failure of the cardiac and vascular system, which will manifest itself in the form of cardialgia, arrhythmia and tachycardia.
- Failure of the hemostatic system and the normal functioning of hematopoiesis, which is usually accompanied by leukopenia. There is also increased bleeding of the mucous membranes and pancytopenia.
- The appearance of aseptic meningitis is quite rare.
Contraindications
In accordance with the instructions for use for Trental injections, they are administered intravenously very carefully.
To avoid the development of an adverse reaction against the background of taking the medicine, you can not use this drug if there are contraindications. It is not recommended to carry out therapy in the event of massive bleeding, an acute form of myocardial infarction, and, in addition, against the background of hemorrhagic stroke. An absolute contraindication is pregnancy with lactation along with hemorrhage in the area of the retina.
With the development of arrhythmias, atherosclerosis and an uncontrolled type of arterial hypotension, the intravenous use of this drug is prohibited. You can not carry out treatment with this medicine in people whose age has not yet reached eighteen years. In cases of non-compliance with the instructions, this drug can cause serious complications and impaired healthy activity of many internal systems of the body. Such information contains instructions for use for Trental injections.
Interaction with other medicines
The drug can not be used alone with other drugs. A visit to a preliminary consultation with a specialist is a prerequisite for a successful, and at the same time, safe treatment. Joint treatment with other drugs can cause the development of negative consequences:
- Pentoxifylline can increase the effectiveness of Trental, which will lead to a significant reduction in patient pressure.
- Thrombolytics, in turn, can increase blood coagulation, reducing the effectiveness of Trental.
- “Cimetidine” increases the risk of developing an adverse reaction due to an increase in the total concentration of the active substance in the blood.
This is described in detail in the instructions for use with Trental 100 mg.
A universal medicine used in various fields of medicine
Medicine with pharmacology are two branches of the modern world, closely interconnected with each other. It will not be possible to imagine medicine today without pharmacological practice or vice versa. This is simply not possible. Medicine today is engaged in a huge list of various diseases. Pharmacology, in turn, has a large list of drugs that are used in the fight against certain diseases. Among modern pharmacological preparations, there are those that are used to treat several diseases at the same time. They are prescribed in various fields of medicine, as they are able to combat many ailments. One of such universal tools is Trental.
First of all, it should be noted that Trental is a drug used in the treatment of atherosclerotic encephalopathy along with ischemic cerebral stroke. In addition, patients take this medication for various disorders of the blood circulation that occur as a result of atherosclerosis, as well as for diabetes mellitus, inflammatory processes and for obliterating endarteritis.
In addition to all of the above, Trental is considered a tool that is suitable for combating trophic tissue disorders, which is a consequence of arterial damage or the result of gangrene, frostbite or trophic ulcers. Often, the use of this drug also helps in the treatment of eye diseases, for example, with disorders of blood circulation in the eye area. Thus, taking the drug is relevant for acute and chronic lack of blood circulation in the retina, as well as when a lack of blood supply is present in its choroid. In otolaryngological practice, Trental is prescribed for the treatment of pathological changes in the work of the inner ear, which, ultimately, if the disease is not treated, can lead patients to hearing loss.
Use of the drug in obstetrics
In accordance with the instructions for use, Trental 100 and 400 mg is a drug that can help inhibit the bonding of platelets and red blood cells. This drug makes human blood less viscous, improving its fluidity. In addition, this medicine slightly affects the expansion of blood vessels, helping to provide tissues with oxygen and blood.
This is confirmed by the instructions for use. Trental 400 and analogues are often used in obstetrics as part of the fight against nephropathy, in simple terms, this means the untimely development in the womb or chronic intrauterine hypoxia. In such cases, the drug is taken one tablet three times a day. In addition to this woman, an intravenous drip of this drug may be prescribed. True, the use of this remedy can lead to the appearance of nausea in a pregnant woman along with vomiting reflexes, a change in stool and allergic reactions. In extremely rare cases, migraine with dizziness may occur.
Instructions for use with Trental in ampoules are quite detailed. It can not be used for patients who have some contraindications. First of all, this drug is forbidden to drink in the presence of bleeding or hemorrhage. It is also contraindicated in cases where women have hypersensitivity to any substance that is part of this agent. Recently, in the framework of recent studies, it was found that Trental can be prescribed for pregnant women, since it cannot have a negative effect on the fetus and the mother herself. Thus, according to recent studies, it turned out that pregnancy is not considered a contraindication for taking the drug presented. But in any case, immediately before use in the presence of pregnancy, you need to consult a doctor.
What information does the instruction for use with Trental 100 mg still contain?
Use of the drug against the background of ischemic stroke
Brain stroke today is at the head of the main causes leading to mortality and disability. The leading position among strokes deals with ischemic disorders of cerebral blood circulation. This is precisely what caused the disease to be dealt with closely. Numerous scientists, within the framework of various studies, have been trying to find effective preventive agents that will help overcome the initial stage of this disease. But, regardless of how much time was devoted to the study of ischemic strokes, the answer to many questions regarding this disease has not yet been found.
Recently, more and more attention is paid specifically to Trental. This drug is a representative of the category of vasodilators. Absolutely all scientists of the world know about this medicine. For the first time they talked about him in Germany. It was there that Trental was used as a drug to combat intermittent claudication. This tool also has an antiplatelet and angioprotective property.
Due to the positive effect on blood rheology and due to the ability to reduce platelet aggregation, the drug is often used to treat patients with ischemic stroke. In addition, Trental is able to increase the elasticity of red blood cells, changing their shape and promoting normal blood circulation. This tool almost always serves as an assistant in the fight against disorders in the circulatory system. But immediately before using it, you need to consult a doctor.
Use in otoneurology
Particular attention is drawn to the possibility of using pentoxifylline for the treatment of patients suffering from circulatory failure of the vertebrobasilar system, and, in addition, in cases where patients have ischemic adverse effects on various parts of the auditory and vestibular analyzers.
Thus, according to studies in which sixty patients took part, it turned out that the use of pentoxifylline in the fight against diseases of the hearing aid is actually effective.For a month, people underwent therapy with the help of Trental. Absolutely all the activity of the inner ear was restored, and, in addition, the blood flow stabilized.
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True, this information is not in the instructions for use. Trental analogs in ampoules and tablets are presented below.
Analogs of Trental
The most effective analogue that can replace Trental is the Agapurin drug. Among the structural substitutes for Trental, which have a similar active component, the following medications are distinguished: Arbiflex, Pentamon, Trenpental, and Radomin.
Drug Reviews
According to doctors, the Trental drug is generally well tolerated by patients. This is also confirmed by the reviews of people who report that this medicine really helped them and turned out to be effective. Adverse reactions mainly occur due to non-compliance with recommendations regarding the use of the drug, as well as with improper dosing. In any case, this is indicated in the instructions for use with Trental tablets. Reviews do not end there.
There are comments about some adverse reactions of the body in the form of a decrease in pressure and the appearance of headaches. As the doctors note, with a decrease in pressure against the background of the use of Trental, it is necessary to reduce its dosage. According to the stories of patients, after reducing the dosage of the drug in such cases, the pressure really quickly returns to normal.
Also, people say that, despite the ban on the use of this medicine during pregnancy, some doctors still prescribe it to women during the period of gestation. Thus, with the permission of the doctor in such situations, the use of the drug is possible. According to reviews, the instructions for use of Trental are very detailed and understandable.
Conclusion
Thus, we can say that the presented drug is more than in demand today. Such great attention is paid to this drug due to its versatility, since it can be used in various fields of medicine, from cardiology to otoneurology, otolaryngology and obstetrics. An equally important advantage is that this medication is fairly well tolerated by patients, but should be prescribed exclusively by the attending physician and should be taken as part of strict adherence to the dosage.
We examined the Trental preparation instructions for use, reviews and analogues.