How effective is such a medication as Orgametril? You can find reviews about this drug at the end of this article. It also provides information about the therapeutic properties of this agent, its indications and methods of use.
Composition, description, form
The drug "Orgametril", reviews of which are mostly positive, is available in the form of tablets (white) with beveled edges, round in shape, with a risk on one side and the inscriptions TT, "4", ORGANON, and also with the image of a star - on other.
The main component of this medication is linestrenol. Also, its composition includes auxiliary ingredients in the form of Ξ±-tocopherol, potato starch, glycerol, magnesium stearate, talc and lactose monohydrate.
The tablets in question come on sale in blisters of 30 pieces, placed in packs of cardboard.
Therapeutic Features
What is the drug "Orgametril"? Instructions, reviews report that this is a synthetic progestogen intended for oral administration. Its active ingredient, linestrenol, has the same pharmacological characteristics as natural progesterone.
According to the statements of experienced specialists, the drug in question is capable of exerting a pronounced progestogen effect on the endometrium. With regular intake of tablets, linestrenol suppresses not only ovulation, but also menstruation.
Use this medication is advisable only in cases where a pronounced progestogenic effect is necessary.
Drug kinetics
Is a drug such as Orgametrile absorbed? Reviews of experts indicate that after taking the tablets, linestrenol is absorbed quite quickly, after which it undergoes transformation in the liver and is converted into active norethisterone. Its peak concentration in the blood is observed after 4 hours.
The half-life of plasma norethisterone after taking the tablets is approximately 8-12 hours. Linestrenol, as well as its metabolites, are excreted by the kidneys (to a lesser extent through the intestines).
Indications
In what cases does the Orgametril medication most effectively manifest itself? Reviews of gynecologists report that the drug in question is indicated for reception under conditions such as:
- endometriosis;
- polymenorrhea;
- dysmenorrhea;
- metrorrhagia and menorrhagia;
- endometrial carcinoma (in some cases);
- benign breast diseases;
- amenorrhea or oligomenorrhea primary or secondary (in some cases);
- as an adjunct to estrogen replacement treatment in postmenopause and perimenopause to reduce the risk of endometrial hyperplasia;
- in order to suppress ovulation (not contraception!), menstruation and ovulatory pain;
- in order to delay normal menstruation.
Bans to use
Under what conditions can a patient not take Orgametil tablets? Reviews (endometrial hyperplasia can be treated very well with this agent) indicate contraindications such as:
- ectopic pregnancy (including history);
- rotor syndrome;
- Suspected pregnancy or already occurred;
- Gilbert's syndrome ;
- lactation;
- Dubin-Johnson syndrome;
- severe liver diseases, including hepatitis or cholestatic jaundice, hepatoma;
- severe depression;
- vaginal bleeding of unknown origin;
- diabetes;
- conditions that may worsen after taking steroid hormones (including otosclerosis, gestational jaundice, pregnant chloasma, porphyria, gestational herpes, and severe itching);
- congenital disorders in cholesterol metabolism;
- thrombosis or thromboembolism;
- hypersensitivity to drug substances.
In the process of taking this drug, it is necessary to constantly monitor the condition of patients suffering from chronic heart failure, arterial hypertension, thromboembolism (including a history) and depression.
Tablets "Orgametril": instruction for use
Reviews say that the medicine in question should be taken orally with a small amount of water.
With polymenorrhea, the dosage of this agent is 5 mg per day (from the 14th to the 25th day of the menstrual cycle).
With menorrhagia and metrorrhagia - 10 mg per day for 10 days. The course of treatment must be repeated during the next three menstrual cycles of 5 mg per day (from the 14th to the 25th day of the cycle).
With endometriosis - 5-10 mg per day for six months in a continuous mode.
With endometrial carcinoma - 30-50 mg per day for a long time.
For benign breast diseases, 5 mg per day (from the 14th to the 25th day of the cycle) for 4 months.
In order to suppress ovulatory pain, ovulation and menstruation - 5 mg per day (therapy should be started from the 1st day of the menstrual cycle). Such treatment should continue for many months.
To delay normal menstruation - 5 mg per day (administration should begin 14 days before the expected menstruation).
How should I take the drug "Orgametril" with endometrial hyperplasia? Reviews of experts say that with such a disease, this medication is prescribed 2.5-5 mg daily for 12-15 days a month.
Side effects
What reactions of a negative nature can Orgametil tablets cause? Reviews of gynecologists report the following possible side effects:
- hypercoagulation, hypersensitivity, weight gain;
- peripheral edema, fluid retention, decreased glucose tolerance;
- increased libido, impaired fat metabolism, decreased libido;
- depression, nausea, increased nervous irritability, headache;
- abdominal pain, excessive sweating, diarrhea, itching, constipation;
- migraine, dizziness, vomiting, jaundice;
- chloasma, acne, rash, seborrhea, hirsutism, urticaria;
- amenorrhea, metrorrhagia, pain in the mammary glands, cervical and vaginal discharge.
If the described side effects appear, you need to tell the doctor about this.
The drug "Orgametril": reviews
Medicines intended for the treatment of various disorders of the reproductive system in the fairer sex are especially actively discussed by patients. About the therapeutic effect of the medication in question, women leave only positive reviews. They argue that this drug is not only a highly effective drug, but almost never causes adverse reactions. However, gynecologists argue that some patients are already worried about being overweight while taking this medication. At the same time, they stipulate that when choosing the right treatment regimen, body weight does not increase.
Experts also report that treatment with this medication can be prescribed to women of completely different ages. In this case, doctors establish a therapeutic regimen and dosage, depending on the complexity and type of gynecological disorder.
Solgano, the opinion of most gynecologists, in order for the effectiveness of this remedy to fully manifest itself, you should undergo prolonged therapy, which will continue for several months.
So, is it possible to take Orgametril tablets with endometrial hyperplasia? Reviews of experts say that with such a disease, this drug manifests itself only from the best side. Therefore, with the diagnosis mentioned, it is prescribed very often.