"Binelol" is a third-generation hydrophobic cardioselective beta-blocker with relaxation of smooth muscles in the walls of blood vessels with effects. The drug has antianginal, hypotensive and antiarrhythmic effects. What instructions for use and analogues does Binelol have?
Structure
The drug is available in the following dosage form - tablets. They are round, milky, with a risk on one side. Capsules are packaged in blisters for fourteen pieces. In total, one, two, four blisters are in the package. The main active trace element is nebivolol hydrochloride. In one tablet, five milligrams. Excipients are the following components:
- polyvinylpyrrolidone;
- a salt of magnesium and stearic acid;
- cellulose;
- crospovidone;
- lactose monohydrate;
- poloxamer.
Pharmacological actions
The active substance "Binelola" is a third-generation adrenergic blocker that has a vasodilating effect. The drug has a hypotensive and antiarrhythmic effect on the body, lowering high blood pressure at rest, during exercise and stress.
According to the instructions for use, Binelol blocks synaptic and postsynaptic beta-adrenergic receptors selectively, changing the release of endothelial vasodilating factor nitric oxide.
The active substance is considered a racemate, which consists of two enantiomers, and has a therapeutic effect combining their actions. The antihypertensive effect of "Binelol" occurs on the fifth day of treatment, a stable effect is recorded after thirty days.
The antihypertensive effect of the drug persists with prolonged use, it is also due to a slowdown in the activity of the renin-angiotensin system. "Binelol" improves performance not only by systemic, but also by intracardiac movement of blood through the vessels, resulting from the difference in hydrostatic pressure in different parts of the circulatory system.
The antiarrhythmic effect is due to the suppression of pathology in the heart and the slowing of conduction. The active substance after oral administration is instantly absorbed from the gastrointestinal tract. Micronutrient absorption is not affected by food sharing.
The rate of purification of blood plasma from nebivolol in a large number of fast metabolizers is approximately twenty-four hours, and its hydroxymetabolites - several days.
The plasma content is proportional to the dosage and varies from one to thirty micrograms per liter. With blood proteins, mainly with simple water-soluble elements.
Third-generation cardioselective beta1-blocker is ninety-eight percent associated. Metabolism is carried out in the liver with the partial appearance of active hydroxymetabolites.
Indications
"Benelol" is recommended for use in the presence of the following conditions and diseases:
- Hypertension (persistent increase in blood pressure from one hundred and forty to ninety millimeters of mercury and more).
- Attacks of angina pectoris.
- Stress in coronary heart disease (a condition in which blood is supplied to the heart in insufficient quantities, which causes oxygen starvation of the heart muscle and the development of necrosis).
- Heart disease (a symptomatic complex characterized by a pathological condition, which is characterized by structural, functional and neurohumoral dysregulation).
Contraindications
The medication has certain prohibitions on the use, for example:
- Diseases of the heart and blood vessels.
- Sensations of interruptions and sinking hearts, short-term dizziness, general weakness.
- High blood pressure.
- Bradycardia
- Metabolic acidosis.
- Myasthenia gravis (an autoimmune disease that causes muscle weakness due to impaired neuromuscular transmission).
- Age to eighteen.
- Breast-feeding.
- Pregnancy.
- Age over sixty five years.
How to take the drug?
Tablets are recommended to be taken orally once a day at the same time. Capsules must be swallowed whole with water. Food does not affect the absorption of an active trace element. With hypertension and cardiac ischemia, adults are prescribed 2.5-5 milligrams once a day, depending on the severity of the pharmacological action. "Binelol" can be used both as a single medication, and in combination.
Patients with kidney disease and people of retirement age should not increase daily dosing. In chronic heart diseases, the dosage is determined individually by the method of quantitative analysis: the initial amount of the active substance is 1.25 milligrams once a day, after a week, it is increased to 2.5 milligrams. If the pharmacological action is not enough, the dosage must be continued to increase every week. First up to five milligrams, then up to ten milligrams. Use "Binelol" regardless of the dose you need once a day.
Adverse reactions
The drug, with improper dosage, can provoke the occurrence of negative phenomena:
- Rashes.
- Itchy skin.
- Bloating.
- Dry mouth.
- Intestinal obstruction.
- Diarrhea.
- Heart rhythm disturbances.
- Fatigue.
- Paresthesia.
- Dizziness.
- Drowsiness.
- Insomnia.
- Hallucinations.
- Depressive disorders.
- Cramps.
- Runny nose.
- Bronchospasm.
Overdose
The following manifestations are considered signs of Binellol poisoning:
- Vomiting
- Lowering blood pressure.
- Cyanosis.
- Pathology, which is associated with a slowdown in the formation of an impulse by the main pacemaker - sinoauricular formation.
- A pathological condition that occurs when the smooth muscles of the bronchi are contracted and their lumen is reduced.
- Loss of consciousness.
- An extreme degree of left ventricular failure, characterized by a sharp decrease in myocardial contractility.
- Heart failure.
The first stage of treatment is gastric lavage and the use of enterosorbents. Subsequently, therapy is carried out depending on the symptoms.
Features
At the beginning of the course of therapy, it is necessary to monitor blood pressure and heart rate every day. Patients of retirement age should be checked at least once every four months for kidney function. With angina pectoris, the dosage of the drug should provide a heart rate at rest within sixty beats per minute, with a load of no more than one hundred and ten beats per minute.
If bradycardia occurs, you need to lower the content of "Binelol" in the blood. If surgery is necessary, the patient is obliged to notify the medical specialist that he is taking a beta-blocker.
The active substance is able to increase sensitivity to allergens, in patients with chronic obstructive pulmonary diseases - increase bronchospasm. In smokers, the effectiveness of beta-blockers decreases. It is not recommended to abruptly stop using "Binelol", therapy should be completed gradually, lowering the dosage for fourteen days.
Can a drug negatively affect my ability to drive?
As a rule, Binelol has no effect on the rate of reactions and attention. But in rare situations, especially at the beginning of therapy and with an increase in dosage, the medication provokes dizziness. It is important for such people to be especially careful when driving.
Can Binelol be used during pregnancy?
In an “interesting situation”, the drug is prescribed only according to strict indications, in a situation where the likely benefit for the expectant mother is significantly higher than the risks for the unborn baby, since the treatment of infants may cause bradycardia, arterial hypotension, as well as hypoglycemia and respiratory paralysis.
Therapy should be discontinued three days before the expected birth. If this is not possible, the baby should be carefully monitored for seventy-two hours after its birth. According to the results of studies revealed that the active substance is excreted in breast milk. Therefore, if you need to use the drug "Binelol" breastfeeding must be stopped.
Analogs
The following medicines are considered substitutes for Binelol:
- "Nebivato."
- Bidop.
- Bivotens.
- "Metoprolol".
- Nevotens.
- "Atenolol".
- "Nebilan."
- "Bisoprolol".
- "Mebicore".
- "Biol".
- "Nebilet".
- Biprol. "
- Aritel.
- "Nebilong."
Next, the most effective and inexpensive substitutes will be considered.
Biol
The drug refers to synthetic drugs with antihypertensive effect, is an analogue of "Binelol." "Biol" is made in the form of tablets, which are coated with a film coating.
In the event of depressive disorders, it is recommended to cancel treatment with a medication. Therapy is not recommended to be stopped abruptly, since there is a high probability of myocardial infarction and severe arrhythmias.
Cancel the drug gradually, lowering the dosage for two weeks or longer, every four days by one quarter. The price of the drug varies from 10 to 200 rubles.
"Atenolol"
The use of tablets helps to have a hypotensive, antiarrhythmic and antianginal effect. The antihypertensive effect of the drug develops over twenty four hours. The emergence of a persistent pharmacological effect is observed after two weeks of constant use of the drug.
Reception of an analogue of "Binelol" helps to increase the survival of people who have suffered myocardial infarction. In such a situation, the use of the drug helps to reduce the number of angina attacks. The price of the drug "Atenolol" is from 20 to 60 rubles.
Bidop
The medicine belongs to the group of beta-blockers and is recommended for people to eliminate cardiac ischemia and hypertension.
Upon penetration into "Bidop" is instantly absorbed through the mucous cavities of the stomach and intestines into the general bloodstream. The drug helps to normalize the functioning of the cardiovascular system, eliminates the symptoms of heart palpitations and eliminates shortness of breath. The cost of the drug varies from 90 to 250 rubles.
Aritel
According to the instructions and reviews for Binelol, Aritel is a substitute for it. A drug that has a hypotensive, antianginal effect. Aritel is prescribed for stable chronic heart failure, which occurs without symptoms of exacerbation.
At the beginning of treatment, it is recommended to carry out constant monitoring by the doctor. In this case, it may be necessary to carry out individual adaptation depending on tolerability. To ensure a certain titration process, it is necessary to use the drug in small doses at the initial stages of treatment. The cost of Aritel is 100 rubles.
"Bisoprolol"
The drug belongs to the pharmacological group of antihypertensive drugs. Their main therapeutic effect is considered to be a decrease in systemic blood pressure, therefore this medication is used for combination therapy of various ailments of the heart and blood vessels.
According to reviews, the Binelol analogue has therapeutic effects that reduce blood pressure and reduce the need for oxygen in the heart muscles and micronutrients, thereby reducing the intensity of the pain syndrome with insufficient microcirculation.
The oral bioavailability of the drug reaches ninety percent, the main component is almost completely absorbed from the intestinal lumen into the plasma. The elimination half-life is twelve hours, which makes it possible to provide the pharmacological effect of tablets during the day. The price of the drug varies from 80 to 250 rubles.
Biprol
The medicine belongs to the group of adrenergic blockers, which with the help of its antiarrhythmic and hypotensive effect is used to eliminate arterial hypertension, ischemia of the cardiovascular system.
The active substance is considered - bisoprolol. It is considered a selective blocker of B1-adrenergic receptors of the heart and practically does not affect B2 adrenergic receptors. The cost of the drug is from 100 to 200 rubles.
How to store the drug?
Keep "Binelol" should be at temperatures up to thirty degrees in a place inaccessible to children. Shelf life is thirty-six months. The drug is dispensed strictly according to the prescription, according to the instructions for use.
Reviews about "Binelol"
People who suffer from high blood pressure and started taking the drug, leave positive feedback about the drug. They characterize it as a fairly good drug that instantly leads to a stable state and reliably maintains normal blood pressure, without any special side effects. As negative sides, they most often indicate the need to take this medication for life and their high cost. The price of Binelol varies from 600 to 1100 rubles.