The drug "Meloxicam" refers to the pharmacological group of Oksikama, has anti-inflammatory, analgesic, antipyretic effect. This medication is available in three forms: a solution for i / m administration, suppositories and tablets. This article is devoted to the description and instructions for the use of the drug "Meloxicam" in the form of a solution for injection and in the form of suppositories (suppositories).
The composition of the drug and the form of release
“Meloxicam” -uccols - solution for intramuscular injection: 1 ampoule contains the active substance meloxicam 15 mg and additional substances in the composition: meglumine, glycofurol, poloxamer 188, sodium chloride; glycine; sodium hydroxide; water for injection. Poured into ampoules of 1.5 ml, blister pack contains 3 or 5 ampoules; a pack of cardboard holds 1 package. The solution is yellow, with a green tint, transparent.
"Meloxicam" -candles - 1 suppository (suppository) contains the active substance meloxicam - 7.5 mg and additional substances in the composition: suppository mass (suppository BP), macrogol glyceryl hydroxystearate. Contour mesh packaging holds 6 pcs.; in a cardboard box - 1 or 2 cell packs. Candles - the surface is smooth, yellowish in color with a green tint, with a depression in the base.
Pharmacological action of the drug "Meloxicam"
The instruction defines it as an anti-inflammatory, analgesic and antipyretic agent.
Pharmacodynamics
The medicine "Meloxicam" is an NSAID, is a derivative of enolic acid and has anti-inflammatory, analgesic and antipyretic effects. The mechanism of the anti-inflammatory effect of the drug lies in its ability to inhibit the synthesis of GHGs, which are inflammatory mediators.
Indications for the use of the drug "Meloxicam"
The solution for injections "Meloxicam" instructions instructs to use this form in the initial period of pain therapy and not for long, in symptomatic therapy for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis.
Meloxicam suppositories are used in symptomatic treatment for osteoarthritis (arthrosis, degenerative joint diseases); ankylosing spondylitis; rheumatoid arthritis.
General contraindications to the use of the drug "meloxicam"
The instruction does not allow the use of the drug with hypersensitivity to the components of the drug; symptoms of bronchial asthma; polyps of the nose; angioedema or urticaria caused by the administration of acetylsalicylic acid or other NSAIDs in history; peptic ulcer in the stage of exacerbation or recently transferred.
It is also forbidden to use the drug for Crohn's disease or ulcerative colitis in the acute stage; severe hepatic and renal failure; acute gastrointestinal bleeding, recent cerebrovascular bleeding or an established diagnosis of diseases that cause disorders in the blood coagulation system; severe uncontrolled heart failure; pregnancy breastfeeding; therapy of perioperative pain with coronary artery bypass grafting.
Additional contraindications for injections: use in children under 18 years of age is prohibited. Additional contraindications for suppositories: in children under 12 years old, an exception is the use in the case of juvenile rheumatoid arthritis.
Side effects when using the drug "Meloxicam"
The instruction warns of possible side effects in the blood forming organs in the form of a change in the blood cell formula.
In the immune system in the form of anaphylactic shock, anaphylactic reactions. In the central nervous system in the form of a headache, confusion, disorientation. In the digestive tract in the form of perforation of the gastrointestinal tract, gastrointestinal bleeding, etc.
In the skin and skin appendages in the form of epidermal toxic necrolysis, Stevens-Johnson syndrome, angioedema, etc.
In the respiratory system in the form of bronchial asthma. In the CVS in the form of increased blood pressure, palpitations, flushing, swelling.
In the genitourinary system, manifestations of acute renal failure, changes in kidney function.
In the organs of vision in the form of conjunctivitis, visual impairment.
Interaction
Concomitant use with other NSAIDs is not recommended.
Overdose
Not enough information.
The use of the drug "Meloxicam"
Injections are given IM only in the first days of therapy (2-3 days). Then treatment is continued with enteral forms. The recommended dose of injection is 7.5 mg or two times more than -15 mg, administered once a day. The recommended daily maximum dose is 15 mg. The medicine is administered deeply in oil. Rectal suppositories are recommended to be used in a dose of 7.5 mg once a day. In some cases, you can double the dose.