“Cefecon D” is an antipyretic and analgesic medicine. Its action is aimed at returning the threshold of thermoregulation to a normal level, as well as combating inflammation.
These suppositories are used to treat children 3 months. - 12 years. Their use is advisable if you want to lower body temperature, which rises against various infections of childhood. It can be scarlet fever, chickenpox, or measles, as well as ARI. It is allowed to use in the post-vaccination period, when there is an increase in temperature.
"Cefecon D" effectively anesthetizes during teething. Perfectly eliminates muscle and headaches.
According to the clinical-pharmacological group, it belongs to analgesics-antipyretics.
Composition, release forms
The medication is produced by the manufacturer for children in the form of suppositories intended for rectal administration. Candles can be white or white with a yellowish or cream tint. The suppository form is torpedo-shaped. The instruction for candles for children “Cefecon D” is very detailed.
The main active component in the composition of the drug is paracetamol. In one suppository it contains from 50 to 250 mg. Vitepsol is present as an additional component.
The drug is packaged in contour blisters for 5 pieces. Each cardboard packaging holds 10 candles.
Pharmacokinetics and pharmacodynamics
According to the instructions, the candles “Cefecon D” have an analgesic and antipyretic effect. Against the background of taking a medication in the central nervous system, a cyclooxygenase blockade occurs. Thus, the active component acts on the thermoregulation system and pain centers. The effect of paracetamol with respect to cyclooxygenase in the focus of inflammation is neutralized by cellular peroxidase. This is due to a significant decrease in the anti-inflammatory effect. The effect of the drug on the mucous membranes of the gastrointestinal tract, on the water-electrolyte balance is not noted. That is, in the body there is no delay in sodium and water. The instruction to “Cefecon D” confirms this.
The drug is characterized by high absorption, it is rapidly absorbed through the mucous membrane. The blood-brain barrier overcomes easily. A slight binding of the active component to plasma proteins is observed (up to a maximum of 10%). Paracetamol metabolism occurs in the tissues of the liver. After 10-60 minutes the maximum level of its concentration is noted. As a result of metabolism, metabolites are formed that do not have activity (sulfates and glucuronides), which are excreted by the kidneys.
Indications for use
"Cefecon D" for children can be used at the age of 3 months. -12 years. In children up to 3 months. a single use of the product is acceptable if it is necessary to lower the temperature due to vaccination. The feasibility of using the medicine at this age for other indications should be determined by the doctor individually.
The specified medication can be recommended for use by children as an analgesic if pain is observed due to injuries, burns, toothache, headache, myalgia, neuralgia. Also, the drug can be used as an antipyretic if the child has the flu, acute respiratory viral infections, heat-producing childhood infections, post-vaccination reactions.
Contraindications
As indicated by the instructions for candles for children “Cefecon D”, the use of candles is contraindicated for children under the age of 1 month, as well as those with hypersensitivity to paracetamol-based drugs. It should not be used in the presence of chronic alcoholism (adults).
Particular care should be taken when prescribing if there are blood diseases (for example, leukopenia or anemia), severe liver and kidney dysfunctions that are caused by a genetic factor such as the absence of the enzyme glucose-6-phosphate dehydrogenase, as well as Dubin-Johnson, Rotor syndromes, Gilbert.
Dosage
What else does the instruction tell us? Candles "Cefecon D" are intended for rectal administration. Suppositories should be administered directly into the rectum. First you need to spontaneously empty the intestines or an enema to cleanse.
The dosage of the drug is set by the doctor, taking into account the body weight of the child, his age. The average recommended dosage is 10 mg / kg. A single dosage should be administered twice or three times a day, frequency - 6 hours. The maximum allowable daily dosage is 60 mg / kg. How to give children under the age of Cefecon D?
- At the age of 1-3 months. and with a weight of 4-6 kg, the recommended single dose is 1 suppository 50 mg.
- At the age of 3-12 months. and with a weight of 7-10 kg, the recommended single dosage is 1 suppository 100 mg.
- At the age of 12-36 months. and with a weight of 11-16 kg, up to 200 mg of the drug should be used at one time.
- Candles "Cefecon D" for children from 3 to 10 years and weighing 17-30 kg should be used up to 250 mg at a time.
- At the age of 10-12 years and weighing 31-35 kg, a permissible single dose is 500 mg.
If “Cefecon D” is used to eliminate the increased temperature, then the period of its use should be no more than 3 days. If for pain relief - up to 5 days. If necessary, the course of therapy can be extended. However, the decision on the advisability of the extension should be made by the pediatrician.
Side effects
When using candles "Cefecon D" can develop various negative phenomena, such as:
- Agranulocytosis, thrombocytopenia, anemia, leukopenia from the hemopoietic organs.
- Quincke's edema, urticaria, itching, as well as a rash on the mucous membranes and skin.
- Vomiting, abdominal pains, nausea - from the gastrointestinal tract.
If the medication is used in large doses and for a long time, the occurrence of nephrotoxic (papillary necrosis, interstitial nephritis) and hepatotoxic effects are not ruled out. Against the background of prolonged use, pancytopenia, methemoglobinemia, aplastic anemia, hemolytic anemia can develop.
Currently, there have been no cases of overdose with this medication.
Interaction with other medicines
According to the instructions for “Cefecone D”, when microsomal oxidation inducers in the liver tissue are taken in parallel (tricyclic antidepressants, phenylbutazone, rifampicin, flumecinol, barbiturates, ethanol, phenytoin), hepatotoxic drugs increase the production of hydroxylated metabolites that have activity. As a result, severe intoxication develops (even if the overdose was small).
Hepatotoxic effects are reduced by microsomal oxidation inhibitors such as Cimetidine.
Concurrent salicylate-based drug therapy increases the risk of nephrotoxic effects of paracetamol.
Joint use with chloramphenicol increases the toxicity of the latter.
With the parallel use of paracetamol and indirect anticoagulants, the effect of the latter increases, and the effectiveness of uricosurics decreases.
Special instructions for use
Before using Cefecon D suppositories, the patient should be warned about the need to seek advice if the fever persists for more than three days and the pain syndrome lasts more than five days.
It is necessary to refrain from taking other medications based on paracetamol, as this can provoke an overdose of this substance.
If the use of the drug for more than a week is indicated, then the liver functionality and peripheral blood parameters should be monitored. Paracetamol is capable of distorting laboratory tests if uric acid and glucose are quantified.
Analogs
Currently, there are a large number of children's preparations based on paracetamol. The most famous are: Efferalgan, Paracetamol MS, Kalpol 6 Plus, Deminofen, Dafalgan, Dainafed Junior, Volpan, Dainafed EX, Bindard, Tylenol Children’s, "Panadol for children", "Paracetamol for children."
It is important to remember that the feasibility of any replacement of the prescribed drug should be determined by the pediatrician. It is extremely dangerous to replace one medication with another, as a child’s body can react unpredictably.
Structural analogues of the active substance: "Aldolor"; Apap "Acetaminophen"; Daleron "Children's Panadol"; "Children's Tylenol"; "Ifimol"; Kalpol; Xumapar Lupocet; "Mexalen"; "Pamol"; Panadol Panadol Junior "Paracetamol"; Perfalgan; "Passage"; "Passage for children"; Sanidol Streamol; Tylenol; "Tylenol" for babies; "Febritset"; "Tsefekon D"; Efferalgan.
Cost
The average cost of candles for children “Cefecon D” ranges from 55 rubles per package containing 10 candles with a dosage of 0.25 g. The average price of a package of 10 candles with a dosage of 0.05 g is 45 rubles. The drug is common, it can be purchased in almost every pharmacy without a prescription from a doctor.
Reviews
Numerous reviews left on forums on the Internet indicate the high efficiency of children's candles. The “Cefecon D” for children will be indispensable in those situations when the child is absolutely not willing to take painkillers or antipyretic drugs in the form of syrups or tablets. Or in the event that the syrups provoke vomiting in the child.
The phenomenon of elevated temperature suggests that the body normally responds to infection. There are frequent cases where parents immediately give their child antibiotics, which is extremely wrong. Suppositories "Cefecon D" in this case are the best option, since their use, most often, short-term and does not exceed 5 days. The democratic price of the drug and the short period of the onset of the therapeutic effect after its use are separately noted.
Parents report that negative effects on the background of the use of the medication are extremely rare, and an overdose if the doctor's recommendations are followed is practically eliminated. The most important thing is not to exceed the dose and not to use other products containing paracetamol in parallel.
The greatest effectiveness of therapy will be achieved when the doctor selects the drug to eliminate the temperature and pain. Only he can exclude contraindications and calculate the correct dosage.
We reviewed the instructions for Cefekon D for children.