The drug "Nolpaza" is a drug from the group of inhibitors, this medication reduces the production of hydrochloric acid, thereby reducing the acidity of gastric juice. "Nolpazu" is used to treat various diseases of the esophagus and stomach, in which it is required to lower acidity. Thus, this medicine is used for peptic ulcer, erosive gastritis, stomach pathologies due to the use of Aspirin, Indomethacin, Ibuprofen, and the like. Use it with stress ulcers, as well as in the case of gastroesophageal reflux disease. Next, we consider the instructions for the use of "Nolpaza", find out what analogues there are, and also learn about its interaction with alcohol.
General drug information
The presented drug is produced in Slovenia. A pharmaceutical concern called KRKA is engaged in its production. The developers envisioned two types of this medicine, namely: Nolpazy tablets and injection solution are produced. Biconvex tablets have an oval shape and are coated with an easily soluble brown shell. The storage temperature of this drug should not be more than twenty- five degrees. As for the shelf life of this medication, it is five years.
Many people wonder if Nolpaza and alcohol are combined. We will talk about this below.
This tool is referred to as anti-ulcer drugs. The active component of the drug inhibits the function of the proton pump in the cells of the stomach. As a result, the production of hydrochloric acid is stopped. The drug is taken regardless of the etiology of the stimulus. Indications "Nolpazy" are indicated in the instructions.
Patients who are forced to take any other drugs at the same time must definitely inform their doctor about them, the fact is that the drug slows down the absorption of drugs, depending on the level of acidity in the stomach.
The composition of the drug
According to the instructions for use, Nolpazu is available in two forms: tablets and lyophilisate for solutions for intravenous injection. The lyophilisate in use is often called ampoules. Tablets are commonly called "Nolpaza 20" or "Nolpaza 40". In this case, the number indicates the dosage of the active substance.
The composition of both forms of the drug in the role of the active ingredient includes pantoprazole in different dosages. Tablets are produced in two doses: 20 and 40 milligrams of the active substance. The lyophilisate for solutions contains 40 milligrams of the main component per bottle. Thus, the finished solution, which is prepared from the lyophilisate, will also include 40 milligrams of pantoprazole. So, why is Nolpaz prescribed?
We will find out what indications for use there are for this remedy.
Indications for use
As indicated by the instructions for use, Nolpaza is indicated for use in the treatment of the diseases listed below.
- Treatment of gastroesophageal reflux disease (GERD) in various forms, including erosive ulcerative esophagitis.
- Relieving symptoms of GERD, for example, eliminating heartburn, pain when swallowing, sour belching, and so on. Why appoint Nolpaz, not everyone knows.
- The treatment of erosion and ulcers of the gastric and intestinal mucosa, which is due to the intake of Aspirin, Indomethacin, Ibuprofen, Nimesulide, Nise, Ketanov, Ketorol and the like.
- The implementation of treatment and prevention of exacerbations of stomach ulcers or intestines.
- Use in combination with two antibiotics in order to eradicate Helicobacter bacteria.
- Ellison syndrome treatment.
Reviews about "Nolpaz" are abundant.
Instructions for use
Consider the rules for using the tablets and ampoules of this drug separately to avoid confusion. Let's start with the pills. Nolpaza tablets of both dosages should be taken orally and swallowed whole. They can not be bitten or chewed. It is also forbidden to grind them in any other ways. Drink the medicine with a small amount of compote or still water. This medication should be taken immediately before meals, preferably before breakfast. In the event that these pills must be taken twice a day, then it is best to do this before breakfast and dinner.
The dosage, along with the duration of use of Nolpase, is determined depending on the disease, because of which this drug is taken. For the treatment of esophagitis, and, in addition, for the relief of symptoms caused by this disease (the presence of heartburn, acid belching, pain when swallowing), Nolpaza tablets must be taken in the following doses, depending on the severity of the pathology:
- For mild severity, they take 20 milligrams of Nolpaza once a day for eight weeks.
- For moderate and severe severity, take 40 milligrams once or twice a day for eight weeks.
After completing therapy, Nolpazu can be taken 20 milligrams once a day for a long period of time in order to prevent exacerbations as part of maintenance treatment. For the treatment of ulcers, Nolpaz is recommended to take 40 milligrams once or twice a day for eight weeks. To eradicate bacteria Helicobacter Nolpazu in combination with antibiotics take 40 milligrams twice a day for two weeks.
As for the ampoules, they are administered only when, for some specific reason, a person is not able to take pills. As soon as it becomes possible to use the drug in tablets, it is necessary to stop the intravenous administration of Nolpaza.
To prepare the solution, open the bottle with lyophilisate and add 10 milliliters of physiological saline to it. Then you need to achieve complete dissolution of the product by gently shaking the bottle in different directions. The prepared solution is injected into the vein jet or infusion.
"Nolpaza" with gastritis
Prescribe a remedy for gastritis when this disease occurs against a background of excessive acidity. The drug corrects the synthesis of hydrochloric acid, eliminating the pronounced symptoms of this pathology. "Nolpaza" is quite well absorbed and easily tolerated by the body, it can demonstrate a lasting therapeutic effect, but only if the medicine is taken correctly. This remedy has contraindications and side effects, in connection with this it is important to consult a gastroenterologist before taking the medicine.
How long should I take Nolpase?
The duration of treatment for gastritis and stomach ulcers is from 4 to 8 weeks. In order to prevent such conditions, Nolpaza is prescribed for use in an amount of 20 mg per day. Treatment of peptic ulcer. With the eradication of bacteria, Helicobacter pylori, the use of "Nolpase" for at least 7 days. With Zollinger-Ellison syndrome, the duration of therapy is individual.
Interaction with other medicines
The medication reduces the absorption of drugs whose bioavailability is maximum against a background of high acidity. We are talking about “Ketoconazole”, “Itraconazole”, “Posaconazole”, “Aspirin”, “Captopril” and “Furosemide”. Nolpaza can also worsen the effectiveness of antiviral drugs for treating HIV infection, for example, it interferes with the work of Atazanavir, therefore it is better to refuse their combined use.
Reception of "Nolpazy" at the same time as "Warfarin" or "Dikumarin" can lead to a change in the international normalized ratio (INR). In this regard, with the simultaneous use of Nolpase and anticoagulants, it is necessary to regularly monitor INR indicators.
Side effects of Nolpaza
Both dosage forms of this drug can provoke the following adverse reactions from the work of various organs and systems:
- The blood system can respond with leukopenia, in which there will be a low level of white blood cells. Thrombocytopenia is also possible when the platelet count is below normal.
- The digestive system can respond to abdominal pain, diarrhea, constipation, flatulence, nausea, vomiting, dry mouth, increased transaminase activity, severe liver damage that occurs with jaundice and can provoke insufficiency of this organ.
- Various allergic reactions are possible in the form of anaphylactic shock, urticaria, itching of the skin or rash, Stevens-Johnson syndrome, and so on. Side effects of Nolpase are prescribed in the annotation.
- The appearance of pain in the muscles or joints is not excluded.
- The nervous system can respond with headache, dizziness, blurred vision, depression, impaired sleep and orientation, hallucinations and confusion.
- From the genitourinary system, interstitial nephritis can be observed.
- Among other adverse reactions, edema and hyperthermia can be observed along with weakness, tension of the mammary glands, increased concentration of triglycerides, bilirubin and cholesterol in the blood. The appearance of asthenia, fatigue, and a general feeling of discomfort is not ruled out. Possible change in body weight.
In the event of severely tolerated adverse reactions, the drug Nolpaza should be stopped immediately.
Contraindications
"Nolpaza" is strictly contraindicated for use in the presence of the following diseases in a patient:
- The presence of individual hypersensitivity or allergic reactions to the components of the drug.
- The presence of hereditary fructose intolerance.
- The development of dyspepsia, that is, digestive disorders of neurotic origin.
- The development of severe renal failure.
- Concomitant use of Nolpaza with Atazanavir.
- The presence of malignant neoplasms of the digestive system.
- Patient is under eighteen years old. Contraindications "Nolpazy" should be strictly observed.
With extreme caution, this drug should be used if the patient has the following conditions:
- The period of pregnancy or breastfeeding.
- The presence of insufficiency
- The lack of vitamin "B12" in the body.
Let's consider analogues of "Nolpaza"
Analogues of the drug
In the domestic market there are two varieties of analogues. These are, first of all, synonyms of the drug and, in fact, the analogues themselves. Synonyms include drugs that, like Nolpase, contain pantoprazole as an active ingredient. Analogues are medicines containing other active components, but they have the most similar spectrum of therapeutic activity. Other drugs from the category of inhibitors act as analogues of Nolpaza.
So, we will first consider the synonyms, which in this case are medicines in the form of “Zipanthol”, “Controlok”, “Krosacid”, “Pantaza”, “Panuma”, “Peptazole”, “Sanpraz”, “Ultra” and “Pulorefa” .
Such drugs as Bereta, along with Gastrozole, Helikol, Dexilant, Zhelkizol, Zerocide, Zolispan, Zulbeks, Lanzabel and Lanzoptol, are considered to be analogues of Nolpaza.
Reviews
Most of the reviews about Nolpaz are positive. This is primarily due to the high effectiveness of the drug in the treatment of various diseases of the stomach. People write that this drug well eliminates the symptoms of gastritis and gastric dyspepsia. Thus, this medicine relieves people of heartburn, belching sour, pain and a feeling of heaviness that occur against the background of chronic pathologies. Also, in case of errors in nutrition or any stressful effects, Nolpaza copes with unpleasant symptoms.
The reviews very often indicate that Nolpaza is fast enough, and at the same time effectively relieves any pain in the stomach, relieving heartburn and curing exacerbation of gastritis, peptic ulcer disease or GERD.
As for the negative reviews about this drug, we can say that they are few in number, and are due to the lack of a therapeutic effect in specific cases. There are also comments that Nolpaza can cause intolerable side effects, as a result of which a person is forced to stop treatment with the drug. Thus, the action of "Nolpaza" is not suitable for everyone, and therefore the appropriateness of its use must be decided with a doctor.
Alcohol interaction
In the instructions for this drug, the manufacturer does not mention anything about the interaction of the drug with alcohol. But can this mean the actual permission to drink during the treatment period? The medical opinion on this matter is absolutely categorical, they are unanimous in the fact that this should never be done.
The fact is that no clinical studies have been conducted that would accurately show the consequences of such a combination. In order to understand what exactly the treatment combined with the use of alcoholic beverages can turn into, one should carefully read the instructions. The presented drug is prescribed for diseases of the digestive system, which means that any alcohol will not only reduce the entire healing process to zero, but also significantly worsen the patient’s condition:
- When ingested, alcohol first enters the esophagus and stomach and causes severe irritation. The stronger the alcohol, the more damage will be. Irritation with alcoholic beverages can provoke the development of esophagitis, that is, inflammation of the esophagus is likely to occur. Alcohol is the main culprit in the emergence of such a terrible disease as cancer of the esophagus.
- Under the influence of ethyl alcohol, the glands that produce gastric juice begin to produce more mucus, and over time they simply cease to function normally and because of this, a person can develop atrophic gastritis. Food will be poorly digested and enter this way into the intestines.
- Alcohol significantly burns the walls of the stomach. In the event that in addition there are certain digestive diseases, additional trauma will only worsen the condition of the organ. Tissue restoration will require a significant amount of time, since regenerative functions will be reduced.
- Drinking alcohol often exacerbates peptic ulcer disease. Alcohol strongly irritates the sensory endings, causing a worsening of symptoms and exacerbating damage to the gastric mucosa. Alcohol can also provoke rupture of an ulcer, the greatest danger in this case exists when blood begins to enter the body cavity. This can be fatal.
- Alcohol can damage the pancreas. The systematic abuse of such drinks contributes to the inflammation of this gland.
- The toxic effects of the decay products of alcoholic beverages impair the functioning and normal functioning of the liver, which is the main filter of the human body.
Nolpaza and alcohol are incompatible. In order for the drug to work most effectively, absolutely nothing should prevent it. This is especially true for taking alcoholic beverages. Combining treatment with a feast, you can not only reduce all the efforts of doctors and your recovery to zero, but also significantly worsen the general condition. We should not forget about the speed of withdrawal of the drug from the body: after the completion of the therapeutic course, it will be in the body for another four days.
We reviewed the instructions for use with Nolpaz.