For the treatment of diseases of the musculoskeletal system, agents based on sodium diclofenac are used, which have an anti-inflammatory, antipyretic, analgesic effect. One such drug is Dicloberl. Instructions for use indicate the possibility of use in rheumatoid diseases, diseases of the joints and muscle tissue.
Description
The medication refers to non-steroidal anti-inflammatory drugs of the first generation without a selective effect on cyclooxygenase. The drug is considered a derivative of phenylacetic acid.
Due to the active substance diclofenac sodium, a pronounced anti-inflammatory effect is achieved by inhibiting the biosynthesis of prostaglandin substances.
It is produced in solid and liquid dosage form with various dosages:
- The drug "Dicloberl 75" in the form of a solution for injection, packaged in 3 ml ampoules with 75 mg of diclofenac sodium. Consumer packaging contains 5 ampoules.
- The drug "Dicloberl 50" in the form of tablets with an enteric-soluble coating of 50 mg of active ingredient, packaged in blisters of 50 or 100 pieces each.
- The drug "Dicloberl retard", produced in capsules with prolonged action with a dosage of 100 mg of diclofenac sodium. Packing in blisters for 10, 20 or 50 pieces.
- The drug "Dicloberl 50 suppositories" is available in suppositories for rectal administration with a dose of 50 mg. Each blister packs 10 or 5 suppositories.
It is produced by the German company Berlin-Chemie AG (Menarini Group).
Mechanism of action
Instructions for use "Dicloberla" determines the anti-inflammatory effect of the drug by changing various links in the pathogenesis of inflammation. First of all, they are associated with antiprostaglandin action, in which the production of prostaglandin mediators is reduced, normalization of increased permeability and microcirculation processes, inhibition of platelet aggregation caused by adenosine diphosphate and collagen molecules, decrease in histamine and bradykinin effects, and decrease in energy.
The analgesic effect is due to the ability to lower the allogeneic properties of bradykinin.
The antipyretic effect is aimed at calming the excitability that occurs in the heat-regulating centers in the diencephalon.
What is treated with the drug
Instructions for use "Dicloberla" indicates diseases associated with rheumatic lesions of the musculoskeletal system in the form of rheumatoid arthritis, rheumatism, osteoarthritis, ankylosing spondylitis.
The medicine is used for gout, dystrophic changes in the joints,
with injuries of the skeleton and muscle tissue, accompanied by pain, swelling and inflammation with inflammatory lesions of the peripheral nerves, with primary dysmenorrhea.
How to take capsules
For the drug "Dicloberl retard", the instructions for use provide for the use of a dose of 100 mg once a day. If there is a need to increase the dose, tablets coated with a special coating or suppositories of 50 mg of diclofenac sodium are taken in parallel with the prolonged form.
Typically, whole capsules are used immediately after ingestion, by mouth. They are washed down with a large volume of water. For patients with disorders of the digestive system, medication is prescribed along with food.
The dosage, depending on the severity, is selected for each patient separately. The permissible limit of the daily content of diclofenac sodium for adult patients and children from 15 years old ranges from 50 to 150 mg.
How to take pills
This dosage form is intended for internal use during meals, so as not to harm the mucous membrane of the stomach. On the drug "Dicloberl" instructions for use of the tablet recommends swallowing whole and drinking plenty of water.
The daily dose, which can be from 50 to 150 mg, is taken 2 or 3 times. The duration of treatment with the Dicloberl 50 medication, the instructions for use advise the doctor to establish it individually individually, depending on the severity of the disease.
Solution use
For deep intramuscular injection into the gluteal muscle, Dicloberl 75 injections are intended. The instructions for use establish a daily dose of 75 mg of diclofenac sodium, which corresponds to one ampoule, and the maximum amount of active substance per day should not exceed 150 mg.
The solution for parenteral administration is not intended for long-term treatment; tablets, capsules or suppositories are used for long-term therapy.
Using suppositories
Instructions for use "Dicloberla" in the form of a suppository of 50 mg has recommendations relatively deep introduction into the rectum, which is carried out after bowel movement. The doctor determines the dosage individually for each patient, based on the severity of the lesion. The amount of active substance per day should be in the range from 50 to 150 mg when used by adults and patients after 15 years. Usually this dose is taken in 2 or 3 doses.
Application features
Instructions for use "Dicloberl" describes in detail cases where caution is needed in the use of the medicine. Such conditions include liver and kidney diseases, erosive and ulcerative lesions, inflammatory processes in the intestine, occurring in the present or in the past, dyspepsia, bronchial asthma, arterial hypertension, heart failure, surgical interventions, advanced age.
If there is a history of possible allergic reactions to non-steroidal anti-inflammatory drugs and sulfites, then diclofenac-based drugs are used only for emergency treatment.
In the event of a severe hypersensitivity reaction that may develop during the first administration, treatment should be discontinued and emergency medical procedures should be performed.
Instructions for use "Dicloberla" stipulates that the treatment process should be accompanied by systematic monitoring of the functional characteristics of the kidneys and liver, peripheral blood should be checked. The period of drug therapy is not recommended to combine with the use of alcoholic beverages.
In case of violation of porphyrin metabolism, acute intermittent porphyria, systemic lupus erythematosus, mixed collagenosis, the drug is prescribed after careful weighing of the ratio of benefit and risk from treatment.
Careful medical supervision is required by patients who have allergic or chronic obstructive diseases of the respiratory system, due to the increased risk of allergic processes. Such reactions can manifest themselves as bronchospasm, Quincke's edema or urticaria, as well as increased sensitivity to other allergens.
Diclofenac sodium may decrease platelet aggregation. In connection with this feature of treatment, patients with impaired blood coagulation need constant monitoring of their health status.
Due to the possible development of adverse reactions from the departments of the central nervous system associated with fatigue, dizziness, a change in reaction and a decrease in attention, the ability to drive vehicles and complex mechanisms may be impaired.
Reviews
People with various diseases of the musculoskeletal system express their opinion on the effectiveness of the drug. The medicine allows many to cope with pain and inflammation in arthrosis of the joints, with pain during movement of the limbs, as well as in a period when the diagnosis is not yet established.
In most cases, you can hear a positive assessment of the treatment with Dicloberl medication. Instructions for use reviews of a negative nature are described in the section "Adverse reactions". This does not mean that undesirable consequences from taking diclofenac sodium must necessarily appear.
There are opinions that indicate the effectiveness of the drug only for the period of treatment of the disease. Some patients believe that the remedy does not cure a person of the disease, but only reduces the pain caused by the disease. There are people who are afraid to take the drug or restrict its use due to negative effects on the liver.
There are positive reviews of the treatment of acute back pain with Dicloberl injections. It was enough to introduce a solution of the drug, as the pain and swelling began to decrease, and after the second injection all the symptoms of the disease disappeared. The patient returned to normal without pain.
The drug begins to be used in cases where other non-steroidal anti-inflammatory drugs do not give a noticeable result.
Price
For patients, it is very convenient when there is an instruction for use in each pack for Dicloberl medicine. The price of each dosage form of the drug is different.
If the treatment is carried out by intramuscular injection, in pharmacies you can buy a package with 5 ampoules of 3 ml of solution in each with a dosage of 75 mg. One pack will cost 430 rubles.
A rectal preparation in the form of suppositories can be used, such information is contained in the Dicloberl medicine instructions for use. The price for a package of 10 candles will average 470 rubles.
For oral treatment, tablets of 50 mg of diclofenac sodium are used. The cost of 50 pieces in a pack is about 395 rubles.
If you need a dosage form with a prolonged action, apply 100 mg retard capsules of the active substance. You can buy 20 pieces for 460 rubles.