A person who has experienced a severe headache at least once in his life knows for sure how important it is to have at hand an effective and effective means to relieve this symptom. The etiology of this phenomenon can be very diverse, so self-medication can be dangerous. The best option is to contact an experienced doctor for advice and the appointment of drugs that are right for you. The specialist will carry out all the necessary diagnostic measures and collect a detailed analysis, on the basis of which a diagnosis will be made and treatment selected.
The article will provide information about the drug "Amigrenin", instructions for use of the drug.
The most intense and prolonged headache attacks are accompanied by migraine. The real reasons for its appearance have not been fully studied, but a relationship has been established between this disease and the state of nervous tension and stress. It is against the background of strong emotional stress that the first bouts of pain in the head appear. If you do not start therapy, then the syndrome intensifies, which significantly worsens the patient's condition. In some cases, the attack can last several days, and the usual analgesics do not have the proper effect. To date, a number of drugs are being produced that are designed to combat migraine, and one of them is Amigrenin. The instruction is very detailed.
Migraine Recognition and First Aid
Differentiating a migraine from a simple headache is not difficult. The disease is quite common and occurs in every fifth person on the planet. Previously, the disease was treated exclusively with natural medicines in the form of herbal decoctions.
At the beginning of the last century, it was possible to establish that the disease is due to genetic characteristics. With a hereditary predisposition to pathology, the irritant can be any level of noise, alcohol, caffeine or stressful situations.
A migraine attack begins, as a rule, suddenly and is characterized by increasing, constant pain in one of the halves of the skull. In addition, symptoms appear such as weakness, dizziness, nausea, darkening in the eyes. It is completely impossible to cure the pathology, but you can learn how to effectively stop seizures at the developmental stage. It is for this purpose that Amigrenin is produced. We will consider the instructions below.
Structure
The medication is in the form of tablets in a soluble coating. In one package there are two tablets, each of which includes:
1. The active substance is sumatriptan succinate in a dosage of 70 and 140 mg.
2. Auxiliary components - lactose, microcrystalline cellulose, potato starch, magnesium stearate, sodium carboxymethyl starch.
In pharmacology, the drug is characterized as an agonist of serotonin 5-HT1 receptors. The main property of the drug is anti-migraine.
This is indicated in the instructions to Amigrenin. The price will depend on the dosage.
The properties
Taking the drug helps to narrow certain vessels that make up the carotid artery system, as well as reduce the intensity of the inflammatory neurogenic process. The advantage of the drug is the lack of effect on cerebral blood flow. In addition, studies have shown that the active substance "Amigrenin" is able to slow down the increased activity of the trigeminal nerve.
Similar properties of the drug can reduce the severity of pain with a migraine attack. The peak of drug activity after administration occurs after about half an hour.
Indications
According to the instructions to Amigrenin, the main indication for its intake is migraine. Experts recommend keeping this medication on hand when headaches localized in the temples and frontal lobe of the skull occur once a month or more often. This is especially true for those who develop additional symptoms such as nausea, tinnitus and dizziness.
It should be remembered that Amigrenin is not a method of treatment, it only relieves symptoms. The drug is designed to stop a migraine attack and relieve pain.
Application
The instruction for taking the drug emphasizes that it can not be used for preventive purposes, since in this case it will not have the desired effect.
For adult patients, the drug is prescribed in a single dose equal to 70 mg, however, sometimes a double dose is possible. The maximum amount of the drug to be taken in one day is 300 mg.
If after taking the first Amigrenin pill, the symptoms do not resolve and do not reduce their severity, you should take a second pill to stop the seizure that is gaining intensity. If the pain is gone or becomes less, and after a while starts to increase again, it is allowed to take a repeated dose over the next day. The interval between pills should not be less than two hours.
Contraindications
As the instructions indicate, "Amigrenin" should not be taken in the presence of the following diseases or conditions:
1. Children's age up to 18 years.
2. Old age over 65 years.
3. Angina pectoris.
4. Stroke.
5. Coronary heart disease.
6. Lack of liver.
7. Such varieties of migraine as hemiplegic, basilar and ophthalmic.
8. The period of gestation and breastfeeding.
9. History of cerebrovascular accident.
10. Increase in blood pressure of unknown origin.
11. Individual reaction of the body to the components in the composition of the drug.
12. Diseases of the peripheral arteries of an occlusive nature.
Amigrenin should be taken with caution in case of uncontrolled arterial hypertension, epilepsy, and also in combination with MAO inhibitors, including during two weeks after completion of the course of treatment with these drugs.
This is confirmed by the instructions for the use of Amigrenin.
Adverse reactions
The main side effect of the drug is its ability to increase or decrease pressure in the arteries. In addition, against the background of taking Amigrenin, the following adverse reactions may develop:
1. Allergic reactions, characterized by itching, rashes on the skin, the development of anaphylactic shock is also possible.
2. Nausea and vomiting, less frequent is also an increase in the activity of hepatic transaminases, colitis of an ischemic type, dysphagia and discomfort in the abdomen.
3. Nystagmus, diplopia, visual impairment up to its partial loss.
4. Drowsiness, dizziness, weakness, sometimes bouts of epilepsy (in the presence of this pathology in the anamnesis).
5. On the part of the heart and blood vessels, disorders such as bradycardia, tachycardia, heart rhythm failure, myocardial infarction, changes in ECG indices, and sometimes Raynaud's syndrome can be observed. Instructions and reviews for Amigrenin confirm this.
When using the drug according to the attached instructions and without exceeding the prescribed dosages, taking the medication extremely rarely provokes adverse reactions. Symptoms of an overdose in this case coincide with side effects. When the above conditions appear, you should stop taking the drug and get a specialist consultation.
Before taking, you should study the instructions for use. The price and analogues of Amigrenin are of interest to many. This will be discussed later in the article.
Features of the reception
In case of epilepsy, including any condition characterized by the appearance of a convulsive syndrome, Amigrenin should be prescribed with caution and under the supervision of a specialist. The same applies to patients with arterial hypertension of unknown origin.
If the drug is prescribed to patients for the first time against a background of atypical migraine or a newly detected pathology, differential diagnosis should be made and other diseases of a neurological nature should be excluded. This describes the instructions for use with Amigrenin. The price depends on the region and the pharmacy chain.
Patients suffering from migraine are at risk of developing complications such as stroke or other circulatory disorders of the brain. You can not take "Amigrenin" for most diseases of the heart and blood vessels.
The first few doses of the drug should occur under strict medical supervision, since the development of spasm of the coronary arteries is not excluded. You should also monitor for a possible allergic reaction to taking the drug.
It should be remembered that Amigrenin can cause drowsiness, so you should exclude driving while taking the drug, as it can slow the psychomotor reactions of a person. This is stated in the instructions for use.
According to reviews, the price of Amigrenin is slightly overpriced - it can reach up to 400 rubles for a package of 2 tablets.
Interaction with other drugs
There are a number of drugs whose concomitant use with Amigrenin can cause the development of some complications:
Ergotamine with sumatriptan can cause prolonged vascular spasm. The interval between taking these drugs should be at least 24 hours.
Concomitant use of the drug with MAO inhibitors is contraindicated.
With the simultaneous administration of sumatriptan and SSRIs, the development of hyperreflexia, weakness, and also a violation of coordination are possible.
Sumatriptan is also not combined with lithium preparations.
This describes the instructions for use.
Analogues of Amigrenin
The most popular generics are the following drugs:
1. "Imigran". The active substance is similar to Amigrenin. The drug costs slightly more than the original (one package will cost about 400 rubles). Imigran is an effective and fast-acting anti-migraine drug.
2. "Sumatriptan." It is produced in Russia and costs half the price than the previous drug. At the same time, the drug is also effective and quickly relieves a migraine attack. It is also produced in the form of tablets in two pieces in one package.
3. "Sumatriptan-Teva." The drug is available at a cost, however, the dosage of the active substance in one tablet is significantly lower than in Amigrenin.
4. "Migrepam." It is found in pharmacies somewhat less frequently than Amigrenin.
5. "Trimigrain." It is made on the basis of the same active substance, but only you are the form of suppositories for rectal administration. The average cost of the drug is 250 rubles. The main advantage of this analogue is its almost instantaneous effect.
The selection of the drug for migraine should be carried out by a specialist on the basis of the patient's medical history and taking into account possible contraindications and adverse reactions. It is not recommended to change one drug for another on its own, as the necessary dosage must be observed.
We reviewed the instructions for use of Amigrenin.
Reviews
Most reviews of the drug are positive. Its performance is noted. It gently and effectively relieves headaches during a migraine attack, eliminating other signs of pathology such as nausea. Many say that the drug became a real salvation, since the attacks could last several days, and with this medication it is possible to stop the migraine at the initial stage of its appearance, without waiting for an exacerbation. The instructions for Amigrenin tablets are simple and straightforward.
Even in advanced cases, the drug no less effectively copes with headaches. Also, the convenience of its use and the compactness of the package are called the advantage of the medication, which allows you to always carry it with you.
Negative comments
A significant disadvantage of the drug in the reviews is its high cost (350-400 rubles). It is especially costly to remove migraine attacks with Amigrenin if they appear several times a week. Another disadvantage is contraindications, namely the inability to take the drug for hypertension. In some patients, the drug causes severe weakness and reduces concentration, which affects the quality of life.
Thus, it is an effective and effective drug in the fight against migraine, which is trusted by quite a lot of people suffering from this pathology.
The article presented instructions for use, price, reviews and analogues of Amigrenin.