What is being said about a drug like Phenylin? Reviews of doctors and patients will be considered at the very end of the article. We will also tell you about the purposes for which this remedy is prescribed, how to take it correctly, whether it has side effects, analogues and contraindications.
Composition and shape
In what form is the phenylin medication made? Instructions for use informs that this drug is available in tablets, the active substance of which is phenindione. As auxiliary components, milk sugar, starch, citric acid and talc are used.
Pharmacodynamics
What pharmacological features does the phenylin medication have? Instructions for use states that this drug has a direct effect on blood coagulation. It is an anticoagulant of indirect action.
Taking the medication contributes to the occurrence of hypoprothrombinemia, which is caused by a violation of the formation of prothrombin in the liver. Also, this tool significantly reduces the formation of factors 7, 9 and 10. Moreover, it has a large cumulative effect compared to neodicumarin.
After oral administration of tablets, the concentration of coagulation factors decreases within 8-10 hours. The maximum effect of the drug is observed after 25-30 hours.
Pharmacokinetics
Is the drug “Phenilin” absorbed into the systemic circulation? Reviews of experts say that this medication is characterized by full and fairly rapid absorption. Its active ingredient penetrates the histo-hematological barriers and accumulates in the tissues.
The drug is metabolized in the liver, and excreted through the kidneys (in the form of metabolites and unchanged).
Indications for use
For what purpose are Phenylin tablets prescribed? Reviews of experts report that this drug is used both for treatment and for prevention. The main indications for admission are thrombosis, thrombophlebitis, thromboembolic complications caused by embolic stroke and myocardial infarction, as well as similar disorders.
In addition, the medication in question is often prescribed to prevent thrombosis after surgery.
Contraindications
Under what conditions of the patient is it forbidden to take the drug “Phenilin”? Instructions for use report the following contraindications:
- impaired kidney and liver function;
- initial prothrombin level up to 70%;
- increased vascular permeability;
- hemorrhagic diathesis and other diseases associated with a decrease in blood coagulation;
- gastrointestinal ulcer;
- malignant neoplasms;
- pericarditis.
We can not say that the drug in question is not recommended for use at the very beginning of pregnancy, for several days after childbirth and during menstruation.
The drug "Phenilin": instructions for use
The medication in question is used only for oral administration. Its therapeutic scheme has certain features, in this regard, the use of this medicine should only be prescribed by a doctor.
The initial daily dose of the drug is usually 0.11-0.17 g (4 single doses). The next day, the amount of the drug is reduced to 0.08-0.14 g, and subsequently to 0.02-0.05 g. After this, the dosage of the tablets depends on the level of prothrombin in the blood.
The maximum amount of the drug at a time should be 0.05 g, and the daily amount should be about 0.2 g.
For the prevention of thromboembolic complications, it is necessary to take 0.03 g of the drug per day, dividing this dose by half.
Therapy of acute thrombosis requires additional administration of heparin. At the same time, strict control by the doctor is required, as well as a mandatory systematic study of the amount of prothrombin in the blood and other coagulation factors.
Treatment with the drug “Phenilin”, the analogues of which we will definitely list below, is stopped gradually.
Side effects
Does the phenylin medication cause side effects? The method of administration and dosage of this medication should be strictly observed. This is primarily due to the fact that during therapy the patient may experience various allergic reactions in the form of diarrhea, nausea and hepatitis. Also, according to reviews of doctors and patients, in rare cases, headaches, fever, discoloration of urine and skin, and problems with blood formation are observed.
Overdose Signs
In case of an overdose in patients, symptoms that relate to side effects may worsen. As a treatment for such conditions, mandatory drug withdrawal is required, as well as immediate intramuscular administration of Vikasol, the administration of rutin, or vitamin P, calcium chloride, ascorbic acid, and general symptomatic therapy.
Medicinal interaction of the drug "Phenilin"
From what this remedy is prescribed, we described above. Let's move on to additional information.
When combining the drug in question with Heparin, salicylates, Cimetidine and sulfonamides, their anticoagulant effect may be enhanced. At the same time, anabolic steroids, Allopurinol, Azathioprine, narcotic analgesics, Amiodarone, tricyclic antidepressants, antibiotics, gluco-corticosteroids, androgens, Diazoxide, Disopyramide, Isoniazid, can increase the effectiveness of Phenilin itself. Butadion, Metronidazole, Clofibrat, Alpha Tocopherol, Reserpine, Quinidine, Paracetamol, Disulfiram, Cyclophosphamide and Thyroid Hormones.
Vitamin K, Propranolol, ascorbic acid, urine alkalizing agents, Rifampicin, antacids, Phenazone, Haloperidol, barbiturates, oral contraceptives, diuretics, Meprotan, Karbamep can significantly weaken the effect of phenindione. Colestyramine. "
Special recommendations
With extreme caution, this drug is prescribed for elderly patients, as well as people with pulmonary embolism, liver and kidney failure, erosive and ulcerative diseases of the gastrointestinal tract, in the postpartum period and with pericarditis.
Treatment with “Pheniline” must be carried out under the special supervision of a doctor with a mandatory systematic blood test for the amount of prothrombin and other coagulation factors. General urine tests are also performed to detect hematuria early.
In some patients, while taking the drug, urine staining in pink, and palms in orange, can be observed. This is due to the metabolism of phenindione.
The drug "Phenilin": analogues and cost
The main analogues of the drug in question are such drugs as Warfapex, Marevan, Neodicumarin, etc.
You can buy the Fenilin medication in the amount of 20 tablets for 120-140 rubles.
Drug Reviews
Is Fenilin effective? Patient reviews about this drug are very diverse. According to their reports, this remedy is one of the most effective drugs that help improve blood condition.
Thanks to therapy, coagulation indices in many patients return to normal. It should also be noted that literally a week after the start of treatment, the patient has an improvement in general condition. At the same time, the numbness of the legs disappears, the spasms cease to disturb the person.
As practice shows, in some patients, while taking Phenylin tablets, nosebleeds increase. However, according to doctors, such changes are the norm. After a course of therapy, everything is normal.
In addition to discussing the effectiveness of the drug, one can also find patients' stories that this drug is often faked. Therefore, when buying it, there is always a risk of acquiring a fake medication. In order to avoid such an incident, you should buy medicines only in trusted pharmacies that have good recommendations.