In the article, we consider the contraindications to Phlebodia. This medication is made in tablet form. The tablets are coated with a special film shell, have a round, biconvex shape, pink color. The section has a gray-brown core with a light mantle around. They are packaged in blisters for 15 pieces. A cardboard box contains 1, 2, 4 or 6 of these packages. In addition, the release form may imply the presence of 1 contour packaging in a cardboard box containing 18 tablets.
The composition of the drug
The composition of the medicine contains granular diosmin, which acts as the main active element and corresponds to purified anhydrous diosmin (dosage - 600 mg). Contraindications to Phlebodia 600 are described in detail in the instructions.
Auxiliary components of this drug are:
- colloidal silicon dioxide;
- talc;
- stearic acid;
- a mixture of dyes - titanium dioxide, ponso 4R (red cochineal), propylene glycol, iron oxide (black and red);
- microcrystalline cellulose;
- opaglos 6000 - beeswax and palm wax, 95% ethanol, gummilak.
The protective film covering the tablet consists of:
- microcrystalline cellulose;
- hypromellose;
- polyethylene glycol stearate 400.
Before talking about contraindications to "Phlebodia 600", consider the pharmacological properties.
Pharmacological properties
The main effects of this drug are aimed at the functionality of the venous bed. The medicine "Phlebodia" has the following effects:
- reduces the extensibility of veins;
- strengthens the walls of capillaries, largely prevents the possibility of damage;
- increases the tone of the vascular walls;
- to some extent eliminates venous congestion;
- increases the resistance of microvasculature;
- reduces the permeability of capillary structures.
The phlebotonizing effect of the main active ingredient is considered dose-dependent, that is, the manifestations of the biological effect are directly proportional to the volume of the medication taken.
In addition, the medicine "Phlebodia" is also able to affect the lymphatic structures. It significantly increases the intensity of capillary contractions, which increases their functional capacity (lymphatic drainage increases), widens the vascular bed, and reduces lymphatic pressure.
Indications and contraindications for Phlebodia 600 should be studied in advance.
The medical product improves the blood supply to the skin, as it facilitates the diffusion of oxygen and perfusion in the epidermis, and also stimulates the microvasculature.
What else needs to be considered?
In addition, it should be noted that the medicine "Phlebodia" actively affects some components of a biological nature:
- prevents the release of prostaglandins, free radicals and thromboxanes into the blood;
- enhances vasoconstrictor properties of adrenaline and norepinephrine;
- reduces the number of free superoxide anions;
- lowers the adhesion of leukocytes to the wall of the venous bed;
- Reduces redistributive migrations of white blood cells into the paranous tissue.
About contraindications to "Phlebodia" and side effects will be described below.
Pharmacokinetics and pharmacodynamics
A drug is rapidly adsorbed from the digestive tract (oral administration). Its active substance is detected in plasma after two hours, and the maximum level in the blood is observed five hours after administration.
Diosmin is deposited evenly - this occurs both in the vena cava and in the vascular bed of the limbs and other body tissues. Active elements are excreted mainly by the kidneys (approximately 80% of a single dosage), to a lesser extent through the intestines (about 11%) and through bile (2.4%).
Indications for appointment
We will deal with contraindications and side effects to Phlebodia later, but for now we’ll talk about the evidence. A medical device can be prescribed to patients as monotherapy or as part of a combination treatment, together with other medicines, if the following pathological conditions occur:
- chronic venous insufficiency;
- a feeling of heaviness in the limbs, especially in the evening;
- varicose veins of the lower extremities located subcutaneously;
- the initial stages of hemorrhoids, pain in the rectum, as well as hemorrhoidal crisis;
- treatment and prevention of impaired functioning of the lymphatic channel;
- burning and fatigue in the lower extremities while being horizontal;
- increased fragility of capillary vessels;
- various disorders of blood microcirculation.
Contraindications to Phlebodia
The pharmacological agent is contraindicated for the appointment of those patients who have the following pathological or physiological conditions:
- Intolerance to the substances present in the composition.
- Hereditary idiosyncrasy or hypersensitivity to the components.
- Also, the lactation period should be considered a contraindication to the use of Phlebodia.
- Age less than 18 years.
All this must be taken into account before the appointment.
Side effects
If contraindications to Phlebodia are not taken into account, the risk of side effects is high. Tablets in most cases are well tolerated by patients, showing the maximum therapeutic result without pronounced side effects. However, the following adverse reactions are described in clinical medical practice:
- dyspeptic disorders (nausea, vomiting, soreness in the upper abdomen, bad breath);
- dizziness, headaches;
- manifestations of allergies (rashes on the skin, itching, angioedema, etc.).
Such negative reactions of the body, as a rule, do not require therapy and disappear on their own after a short break in conservative treatment. About contraindications and side effects of "Flebodia 600" it is better to get a complete picture.
Instructions for use
The tablets of this medication are administered orally. Reception does not depend on meals, wakefulness periods and physical activity. The treatment regimen should be prescribed individually by the attending physician, however, in most cases, it follows one of several most effective methods.
If the medication is prescribed for the treatment of varicose veins or chronic venous insufficiency, the daily dosage of this medicine is 1 tablet. The course of taking the drug depends on the pathophysiological stage of the pathology: at the initial stages of development, tablets are required for 2 months, and at later stages - 3-4 months. If trophic changes occur on the skin (necrotic ulcers as the last stage of the development of the pathological process), the course is extended to six months.
Instructions for taking the "Phlebodia" remedy for exacerbation of hemorrhoidal inflammation of the rectal region implies the appointment of the drug for 2-3 tablets per day in order to stop acute conditions. Further, if necessary, the course is extended with one tablet per day for 2-3 months.
During the 2nd and 3rd trimesters of pregnancy, this medication helps to get rid of lymphovenous insufficiency, which is chronic, if you take the pill 1 time per day. The therapeutic course is recommended to be carried out under the supervision of a qualified specialist, that is, with inpatient therapy. Termination of rehabilitation is necessary 2-3 weeks before the birth, which the attending physician should inform about, as well as about contraindications and side effects of "Flebodia 600". Reviews of the drug should be consulted in advance.
special instructions
In the treatment of acute hemorrhoidal crisis, it is necessary to observe a proctologist and carry out regular additional diagnostic tests, since the medication may not have its pharmacological effect right away, and this can worsen the patient's condition and provoke the progression of the pathological process - until the inflamed hemorrhoidal nodes fall out of the rectum. In the absence of a quick effect, treatment should be supplemented with specialized medications tonic and hemodynamic effects.
Analogs
Angioprotectors are a category of pharmacological agents whose effects are aimed at strengthening the walls of the bloodstream, preventing the development of vascular insufficiency and stagnation of blood in the veins, the pathophysiological effect on the vessels of the lymphatic system and biologically active elements that regulate these indicators.
Thus, in addition to the Phlebodia medication, the following medications are widely used:
- “Vazoket” - a medication based on diosmin, which has a venotonic effect (reduces the extensibility of veins), increases the tone of the veins (with a dose-dependent effect), reduces the level of venous stagnation, improves lymphatic drainage (increases the tone of lymphatic capillaries, increases their functional density, blocks lymphatic pressure) , normalizes microcirculation, reduces the adhesion of leukocytes to venous walls and their migration into the paravenous tissue, has anti-inflammatory properties.
- "Diovenor" is a medicine whose action is expressed in increasing vascular resistance and resistance of venous tone and capillaries, eliminating capillary permeability and venous stasis, and also enhancing lymphatic drainage. This medication is used for varicose veins and insufficiency of the vascular system of the body.
- Detralex is an analogue of the Phlebodia medication. Which in addition to diosmin contains another active element - hesperidin. This medicine has an angioprotective and venotonic effect. The drug reduces the extensibility of veins, eliminates stagnation of blood in them, the permeability of capillaries.
Pregnancy
What you need to know about the indications for use and contraindications of Phlebodia regarding use in pregnant women?
This drug has participated in numerous studies on teratogenicity, and they showed a negative result. Thus, there was no negative effect for the developing fetus. However, in order to avoid unwanted reactions or incidence of involution, a therapeutic course is prescribed only after the end of the first trimester of pregnancy.
Medication cost
The price of the Phlebodia medical product in Russian pharmacies ranges from 520-560 rubles per pack of tablets. It depends on the region.
We learn what people write about the testimony and contraindications of Phlebodia in their comments.
Reviews
Reviews of the drug in the treatment of hemorrhoids confirm the effectiveness of its pharmacological properties. The pathophysiological effect of the drug in a relatively short time allows a conservative method to treat inflammation of hemorrhoidal caverns, even at advanced stages of the pathology. In addition, tablets help to alleviate the course of acute crises, which has a very positive effect on the general condition of patients.
Expectant mothers who underwent treatment for lymphovenous insufficiency during pregnancy were also completely satisfied with the effect of this pharmacological drug. Plebodia tablets, according to them, allow you to get rid of the discomfort and discomfort that accompany stagnation of blood and lymph in the limbs, which greatly facilitates the course of pregnancy. Separately, it should be noted that due to the increased blood supply to the skin and the pronounced venotonic effect, the Phlebodia medication helps to provide a cosmetic effect.
People with varicose veins have also left a lot of positive reviews about this medicine. They note that the veins affected by the pathological process began to hurt less, swelling of the legs and a feeling of fatigue decreased.
The reviews of medical specialists using a medication in their practice characterize this remedy on the good side, since the pharmacological effect exerted by it occurs quite quickly. The main thing is to take into account the contraindications of Phlebodia.
As for the side effects that may occur during treatment with this drug, it is noted in the reviews that the tablets are easily tolerated by the body and practically do not provoke the development of undesirable effects. Despite this, in a few patients, mild digestive disorders, dyspepsia, and changes in stool consistency occurred. Such symptoms were mostly short-lived and disappeared on their own.