Consider the instructions and reviews for "Ramazid N". This drug is classified as a therapeutic agent, characterized by a combined effect. It is suitable for normalizing high blood pressure in patients. The main active ingredients of this pharmaceutical agent are hydrochlorothiazide and ramipril.
Structure
The main components of the medication presented are ramipril and hydrochlorothiazide. Additional substances are sodium carbonic acid salt along with milk sugar, croscarmellose and corn flour (starch). Feedback on Ramazide N will be presented at the end of the article.
Release format
"Ramazid N" is produced in the form of tablets. The color of the pills is white, and their shape is oval. Type of packaging: blister. This therapeutic agent is made in two dosages:
- The substance ramipril in an amount of 2.5 mg, and hydrochlorothiazide - 12.5 mg.
- Ramipril - 5 mg, and hydrochlorothiazide - 25 mg.
The medicine in question is produced by the Icelandic company Actavis.
Drug properties
The substance ramipril is classified as an angiotensin converting enzyme inhibitor. This component accelerates coronary circulation, decreases the overall peripheral vascular resistance, normalizes the pressure in the capillaries and pulmonary arteries. In addition, the described medication reduces the production of aldosterone along with the loss of potassium. The drug in question begins to act one and a half hours after administration. As a rule, the effect of treatment persists throughout the day. This is confirmed by the instructions and reviews for the Ramazid N tablets.
The second ingredient, hydrochlorothiazide, is considered a thiazide-type diuretic; its main function is to inhibit the absorption of chlorine, sodium, potassium, as well as magnesium and water. Thanks to it, the excretion of calcium and uric acid from the body is blocked.
The effect is usually achieved due to a decrease in the amount of circulating blood, a change in vascular reactivity, as well as an increase in depressant effects on nerve nodes. This medicine begins to work one or two hours after taking the pill, the therapeutic effect of it lasts from six to 24 hours. Under the condition of constant intake of the drug in question in the body, the volume of the myocardium decreases, the process of platelet gluing decreases, the heart rate along with the blood flow improves. According to reviews, Ramazid N is very effective.
Pharmacokinetics
The main component, ramipril, can be absorbed in two to four hours. The process of hydrochlorothiazide absorption usually takes from one to five hours. This active component combines with plasma proteins by 73%, and the second substance, which is hydrochlorothiazide, by 65%. Withdrawal of the drug occurs through the kidneys. The body cleansing time is from five to fourteen hours.
Indications for use
Ramazid N pills are used only if patients have arterial hypertension. This drug is suitable for use by those patients who are prescribed combination therapy with ramipril and hydrochlorothiazide.
Instructions for taking and dose
As a rule, treatment with Ramazid N pills begins with a minimum dosage. If necessary, the volume of the drug can be gradually increased to the maximum level (10 mg ramipril and 25 mg hydrochlorothiazide per day). Such a volume of medication is used until the desired pressure indicator is reached.
If the patient receives diuretics, then before starting treatment, you need to reduce their number or completely stop taking them. In general, the doctor selects the dose for each patient individually, depending on what kind of blood pressure is observed in the patient and his general condition is taken into account. The drug is taken once a day, preferably in the morning. It is impossible to chew and grind it.
Interactions with other medicines
It is better to familiarize yourself with the reviews about Ramazid N tablets in advance. The effect of the treatment in question is enhanced by drugs to normalize high blood pressure, as well as vasodilators, barbiturates, phenothiazine drugs, tricyclic antidepressants and ethyl alcohol.
The effect of taking this drug can reduce salt intake, the use of vasopressor sympathomimetics, non-steroidal anti-inflammatory drugs, indirect antithrombotic drugs, and medications containing clofibrate. The use of "Ramazide N" and drugs that contain a high dose of lithium leads to the accumulation of this element in the body.
Side effects
According to reviews of Ramazid N, the pharmaceutical in question can cause headaches in people, along with pressure in the temples. During treatment, patients may experience side effects in the form of a significant decrease in pressure, orthostatic collapse, increased heart rate, kidney failure, and decreased urine.
In addition, the appearance of migraine, a state of weakness and drowsiness, anxiety, various disturbances in the normal functioning of auditory, visual, tactile and olfactory organs, deviations in the functioning of the intestines and liver are not ruled out.
According to reviews, the Ramazid N tablets can be treated by the body with nausea, pain or discomfort in the epigastric region, a feeling of dry mouth, shortness of breath, rash, itchy skin, photosensitivity, muscle cramps, fever, and so on. It is worth noting that all of the above side effects directly depend on the individual characteristics of the body of a patient.
Contraindications
The medication in question is not recommended for use against the background of the following conditions and diseases:
- In the presence of Quincke's edema and kidney pathologies.
- In the case of undergoing therapy with an artificial kidney apparatus.
- Against the background of the development of aortic stenosis or mitral heart valve.
- In the presence of cardiomyopathy, Conn's syndrome or gout.
- The lack of potassium and sodium in the blood.
- Against the background of an excess of calcium in the body.
- Under the age of 18.
- In case of individual intolerance to the substances that make up the drug in question.
- During pregnancy. Take "Ramazid N" during gestation and in case of breastfeeding is strictly contraindicated.
Overdose
According to reviews of Ramazid N pressure pills, taking excessive doses of the described medicinal product threatens the following symptoms of overdose: excessive lowering of blood pressure, weak heart rate, state of weakness and shock, dry mouth, disturbances in water and electrolyte balance. As part of first aid, a person needs to be placed in a supine position, and then raise his lower limbs.
In the event of a slight overdose, patients undergo a gastric lavage procedure along with the use of sorbents. In the presence of a serious condition, patients are treated in a hospital.
What else should you know about the medication?
We give additional information about this drug:
- With the joint use of food, the rate of absorption of the described drug decreases.
- The use of the drug as part of therapy reduces the effects of oral contraception.
- Patients who are in advanced age, this drug should be drunk with great care.
- Ramazid N is a prescription drug.
- It affects the driving and the work associated with interacting with complex mechanisms.
- At the beginning of taking the pills, you need to regularly diagnose kidney function.
special instructions
Some caution must be exercised when prescribing this remedy to patients who are on a salt-free diet (due to the increased risk of developing low blood pressure). In patients with a small volume of blood (as a result of treatment with diuretics) against the background of dialysis, with vomiting and diarrhea, the appearance of symptomatic hypotension.
In patients who undergo extensive surgical interventions or receive other drugs that cause a decrease in pressure during general anesthesia, ramipril may provoke blockade in the formation of angiotensin due to the renin release process. If the doctor associates the appearance of low pressure with the mentioned mechanism, then this condition should be corrected by an increase in the volume of blood plasma.
Arterial transient hypotension is not a contraindication for continued therapy after pressure stabilization. In the event of a repeated appearance of a marked decrease in indicators, the dosage should be reduced or the drug should be canceled at all.
Terms and conditions of storage
The drug must be kept away from the sun and it is also necessary to limit the access of children to it. Such a product should be stored in a dry place at a temperature of up to 25 degrees. Shelf life is three years.
Price
In Russia, an average of 400 rubles is required for 30 tablets with a dosage of 2.5 mg of ramipril + 12.5 mg of hydrochlorothiazide. It all depends on the region.
Analogs
If necessary, you can replace the described medicine with an alternative medication. For example, among its analogues it is worth mentioning Amprilan along with Khartil-D, Aritel Plus, Bisangil, Renipril, Triamtel, Enalapril N, Akkuzid, Simartan N, Enap ”,“ Mikardis ”,“ Lysoretic ”,“ Lodoz ”,“ Coaprovel ”and others. According to reviews, the analogues of "Ramazid N" work no worse.
It is important to note that, if necessary, a substitute medicine is prescribed only by a doctor according to the individual characteristics of the patient’s health status.
Reviews on "Ramazide N"
On the Internet on different sites, as well as forums, there are not very many comments about this tool. But those people who suffer from high blood pressure and who have ever taken the medicine "Ramazid N 2.5" in the reviews report on its effectiveness, and at the same time on a fairly quick effect on the body.
The minuses of the described tablets, consumers include a large number of different contraindications and adverse reactions, as well as the existing ban on taking this drug for pregnant and lactating women.
Some write that, after prescribing them this medication, unfortunately, did not fit, against the background of its use, side effects appeared in the form of nausea and a general deterioration in well-being. Doctors, in turn, comment on such situations by the need to replace "Ramazid N" 2.5 mg.
In the reviews, people also say that this drug, on the contrary, serves as a good assistant for pressure, in connection with which patients can use it for years and achieve the necessary therapeutic effect. According to doctors, a lot depends on the body, so some perceive this medicine, while others have to pick up analogues.
As reported in the reviews of "Ramazide N", if the drug is suitable, it can be drunk for a long time, it helps to feel good, keeping the pressure always normal, and side effects do not bother at all. Thus, quite often in the comments you can read that these pills do their job. They do not cause allergies in most patients.
Some complain that this drug is slightly more expensive than Russian counterparts, but many people believe that it’s better to overpay for quality to achieve the desired therapeutic effect. It is also noted that these pills are not large and are swallowed without problems. This is confirmed by reviews of "Ramazide N" 5 mg / 25 mg. 30 tablets per pack is very convenient.
Thus, the drug is a combination drug suitable for the effective treatment of hypertension. Regular administration of the pharmaceutical in question helps control blood pressure and has a diuretic effect. The remedy has a number of contraindications, which you must definitely familiarize yourself with before starting treatment. This can be done through the instructions for use. Reviews about "Ramazide N" should also be read before use.