A non-steroidal anti-inflammatory drug produced in Romania is one of the leading medications prescribed for the treatment of diseases of the musculoskeletal system. It also has a pronounced antirheumatic effect. The medical drug “Diaflex”, reviews of which are both positive and negative, is prescribed, in particular, for osteoarthritis. This disease affects the joints, as a result of which the cartilage tissue is especially deformed and changed , which leads to painful consequences.
“Diaflex” tablets are produced in the form of capsules with a dosage of the active substance of diacerein of 50 mg. In drugstores, the medicine is dispensed exclusively by prescription, as it has a specific effect on the human body and interacts with other medications.
The pricing policy of the drug is available to the average part of the population. It is included in the State Register, certified, has parameters that meet the standards, and the official trade name is “Diaflex”. Analogs, the price of which varies widely, have the same active ingredients and composition.
Qualitative and quantitative characteristics
The capsule "Diaflex Rompharm" has a shell of hard gelatin light brown in color, which contains a free-flowing substance. Chemical composition and weight content:
- iron oxide (III) - 2.2 mg;
- titanium dioxide - 750 mcg;
- gelatin ~ 75 mg.
Active and auxiliary compounds of the drug:
- diacerein in an amount of 50 mg;
- magnesium stearate - 12.5 mg;
- lactose monohydrate ~ 250 mg.
Pharmacological effects
The drug itself, as well as the analogue of Diaflex, Vipraksin injection solution, has anti-dystrophic and anti-inflammatory effects on the human musculoskeletal system.
The main compound is restored to an active metabolizing form, which is able to suppress the action of inflammatory mediators, in particular interleukin-1 and -6, tumor necrosis factor-alpha. The effect on the body begins to appear after taking the drug for 2-4 weeks. With oral administration of the “Diaflex” agent, the patient’s reviews of which fully confirm the therapeutic effect declared by the manufacturer, an anti-inflammatory and analgesic effect on the foci of the disease occurs.
Chemical kinetics of ongoing processes
The drug, like the Diaflex analogue - Arthra Chondroitin tablets - is absorbed relatively quickly by the gastrointestinal tract, entering the bloodstream. It is recommended to take the medicine along with the main food intake, in this case, the absorption of the substance increases significantly by about 25%. With a single use of the drug, the maximum concentration of the active substance in the human body is 3.15 mg / l. With constant intake, accumulation occurs, therefore, the content of diacerein increases slightly. The highest concentration is reached after 144 minutes.
The active substance is completely reduced to rhein, which is almost completely bound to proteins. In addition, the medicine has the ability to pass through the placental barrier and enter the central nervous system from the circulatory system. The half-life of rhein is 255 minutes. From the body, the substance is excreted in the urine in the form of sulfates, glucuronide and slightly unchanged.
Indications for use
The drug is prescribed for osteoarthritis of the primary and secondary. These are diseases that affect joint tissues mainly in women during menopause, as well as in people over sixty years old. In some cases, as part of a complex of preparations for osteoporosis, the medicine also has a positive effect.
The strategy of using a particular medical product must be developed by a doctor. Self-medication is strictly prohibited. It is recommended that you carefully study all the information about the drug "Diaflex" instructions for use. Analogs can have other side effects, the specifics of the effect on the human body and the different effectiveness of the active substance in the fight against the disease.
Prohibition of use
Treatment with this drug during pregnancy and lactation is contraindicated, since the active substance, breaking the placental barrier, has a detrimental effect on the fetus and, as part of mother's milk, adversely affects the health and development of the baby. All analogues of such a medicine are also prohibited in this category of patients. The active substances that make up their composition are harmful to the infant body and may accompany the development of pathologies during the formation of the fetus.
Limitations and contraindications
The analogue of "Diaflex" - "Actasulide" - in tablets is not prescribed for the treatment of adolescents under the age of eighteen. It is also not recommended to use the drug in the presence of individual intolerance to some of its components. If you have a syndrome of low absorption of glucose and galactose, as well as lactose deficiency, the drug is strictly contraindicated for you.
The use of the drug should be carried out under strict supervision and only as directed by the doctor in the presence of inflammatory processes in the gastrointestinal tract, renal or hepatic insufficiency, or bowel obstruction.
Dosage and treatment period
Taking the drug Diaflex Rompharm, reviews of which say that in the first two weeks of using the medicine, intestinal motility is accelerated, it is recommended to start with one capsule per day after the main meal, without destroying the capsule shell and drinking plenty of water. After four weeks, it is necessary to increase the dosage twice - in the morning and in the evening, therefore, 2 capsules should be taken per day, which is a total amount of the active substance of 100 mg.
The result of the use of the drug appears on average after a period of time from two to four weeks. The general course, which includes other analogues of drugs of a similar spectrum of action, should be at least four months. Based on the degree of effectiveness of the fight against the disease, the attending physician may prescribe a longer period of admission.
Side effects on the body
When using the drug, the following reactions from the gastrointestinal tract were noted: pain in the abdomen, nausea, vomiting, upset stool. Allergic manifestations: urticaria, bronchial spasms, anaphylactic shock, symptoms of fever, swelling of the mucous membrane. In addition, a general malaise can be observed, as well as a change in the normal color of urine to brown due to a violation of the acid-base balance. Here is all the information that the instruction provides us about the drug "Diaflex". Analogues of the drug may have similar and other side effects.
Overdose cases
Recorded data on exceeding the recommended concentrations of the drug. Patients experienced a general deterioration in well-being, lethargy, and digestive upset. When you stop taking or restore the desired dosage, the symptoms are usually removed. No more serious consequences were recorded, unlike other drugs for osteoporosis. The medicine, even in case of an overdose, does not adversely affect the body, which could not be restored.
Interaction with other medical devices
Antacids and any anti-diarrhea and poisoning agents that have absorption properties significantly reduce the absorption of the drug, as they absorb it. Any other analogue of "Diaflex", which includes an excellent active substance, may not depend on the intake of such funds. Also, the combination of the drug with a laxative or substances that increase the volumetric content of the stomach, for example, bioadditives, which have a lot of fiber in their composition, is contraindicated.
Taking antibiotics, combining treatment with a course of chemotherapy, as well as other manipulations or drugs that disrupt the normal intestinal microflora, can lead to significant problems in the digestive system.
Other tips for use
The duration of admission, changing the standardized dose and repeating the course can only be prescribed by a specialist doctor. The use of analgesic drugs is recommended to be stopped after the appearance of a pronounced therapeutic effect from treatment with diacerein.
The doctor, while taking the drug “Diaflex Rompharm”, is obliged to periodically monitor certain parameters, directing the patient to take blood, urine and liver tests. It is important that these characteristics are normal, as the results make a conclusion about the effectiveness of treatment, the necessary dosage, duration of therapy, repetition of the course or replacing the drug with an analogue. When passing the tests, it is necessary to inform the laboratory assistant about the treatment with diacerein, since the urine has a specific color, and in the implementation of some studies deliberately false conclusions are possible.
For patients with chronic kidney disease, the standardized dose of the active substance is half of what is stated in the instructions. In the further picture of the treatment, its increase is possible under the strict supervision of a doctor.
Reception of "Diaflex" does not affect the patient's ability to drive a car, as well as work with potentially dangerous mechanisms and structures.
It is recommended to store the drug at a temperature not exceeding 25 degrees Celsius in a dry place inaccessible to sunlight and children. Use the medicine should be prescribed for 3 years.
Reviews about the drug "Diaflex"
Most of the Internet forums dedicated to medicine and treatment with certain drugs contain many reviews about Diaphlex Rompharm. Often patients complain about the duration of the reception and the late effect, as well as the fact that they have to take additional painkillers. Although the instructions for the medicine indicate that the drug acts that way.
At times more, you can find positive comments that confirm the efficacy and effectiveness of the drug in the fight against the most serious joint disease - osteoarthritis. Users note that on average, a positive effect is manifested by about the second week of admission, and the results are fixed for a long time. Many go to repeated courses with the drug “Diaflex”, since the effectiveness of such treatment is justified by high efficiency.
Analog range pricing policy
| Drug name | Average cost (in rubles) |
| "Diaflex Rompharm" | 1000 |
| "Artroker" | 1040 |
| "Artrodarin" | 2200 |
| "Arthra Chondroitin" | 885 |
The cost of "Diaflex Rompharm" and its analogues ranges from 800 rubles to 2500 thousand per package. The price of the same drug may vary depending on the pharmacy where it is sold. There is no guarantee that a more expensive product will work better than a budget one. In this case, the individual parameters of the body and the severity of the disease play a role.