At what dosage is Midrimax prescribed? Instructions for use, a photo of this medication will be presented later. From this article you will learn about the form in which the mentioned product is sold, whether it has substitutes, in what cases it is prescribed, what patients say about it and so on.
Form, packaging, composition
What packaging is Midrimax sold in? Instructions for use are enclosed in a cardboard box. It also contains a dropper bottle with a medicinal substance.
This drug is available in the form of eye drops. Its active ingredients are tropicamide and phenylephrine hydrochloride. As for auxiliary ingredients, they use sodium metabisulfite, disodium edetate, benzalkonium chloride, hypromellose, sodium hydroxide, distilled water and hydrochloric acid.
Features of the medication for the eyes
What is the drug "Midrimax"? Instructions for use, reviews of doctors say that such drops have a diagnostic purpose. Their active components contribute to blocking the m-cholinoreceptors of the ciliary muscle and the iris sphincter. Due to this effect, paralysis of accommodation and expansion of the pupil occur.
The effect of using an ophthalmic preparation occurs very quickly and is observed after about 5-12 minutes. He reaches his maximum after 47 minutes.
The effect of this medicine, although quick, is extremely short-lived. The drug is only 1-2.5 hours.
To reach the initial pupil width, the patient will need approximately 6 hours.
Pharmacokinetic indicators of active substances
What pharmacokinetic properties does the drug "Midrimax" have? The instruction says that both active components of this medicine have completely different indicators.
Phenylephrine quite easily penetrates into all tissues of the eyes. The peak of its plasma concentration is observed approximately 10-20 minutes after topical application. Moreover, it is eliminated by the kidneys (about 20%) in unchanged form or in the form of inactive metabolites.
As for tropicamide, it is also able to penetrate the tissues of the eye. This substance is very rapidly absorbed into the systemic circulation. The maximum concentration of the substance in plasma is observed after 5 minutes.
Indications for use
Do you know what Midrimax (eye drops) is for? The instruction reports the following indications for the use of this tool:
- for diagnosis in ophthalmic practices;
- laser and surgical operations.
Contraindications
What conditions of the patient are forbidden to use drops "Midrimaks"? Instructions for use indicate the following contraindications:
- angle and narrow angle glaucoma;
- hypersensitivity to the main and additional elements of the drug;
- type 1 diabetes mellitus;
- diseases of the cardiovascular system (for example, angina pectoris, arrhythmia, coronary sclerosis or hypertensive crisis);
- age category (people under the age of 18);
- thyrotoxicosis;
- pregnancy and breastfeeding;
- the use of monoamine oxidase inhibitors, as well as 1 month after the abolition of MAO.
Careful reception
With extreme caution, the medication "Midrimax" (instructions whose analogues are described in this article) is prescribed for:
- type 2 diabetes;
- in old age with a high risk of developing ventricular arrhythmias and myocardial infarction.
Drops "Midrimax": instructions for use
The medication should be used conjunctively.
To expand the pupil for the purpose of surgical intervention or ophthalmic diagnosis, 1-2 drops (in each eye) should be instilled into the conjunctival sac . It is advisable to carry out these procedures half an hour before the start of an operation or diagnosis.
In order to reduce the risk of developing systemic side effects after instillation of the drug (after about 1-2 minutes) on the area of the lacrimal sacs in the inner corners of the eyes, you should easily push with your fingers.
Overdose cases
What signs of an overdose can occur if the Midrimax medication is used improperly? Instructions, reviews of experts report that if the drug accidentally enters the body, then the patient may experience heart palpitations, dry mucous membranes and skin, hyperthermia, cramps, mydriasis, agitation, coma and respiratory depression.
To eliminate such deviations, the patient is washed with a stomach, and absorbents are also prescribed.
To remove hyperthermia, experts recommend the use of cold compresses. To stop the systemic effects of phenylephrine, α-blockers are used.
Local side effects
What local side effects can the drug “Midrimax" cause (drops)? The instruction informs us of the following possible effects:
- allergic reactions;
- transient decreased vision and pain;
- photophobia;
- increased intraocular pressure;
- burning eyes;
- keratitis;
- pigment release;
- conjunctival hyperemia;
- lacrimation
- reactive miosis, especially after the first application, and subsequently not very pronounced mydriasis (most often observed in the elderly).
Systemic side effects
The following conditions are referred to systemic side effects of this drug:
- a feeling of dry mouth;
- pallor or redness of the skin;
- headaches;
- contact dermatitis;
- increase in blood pressure;
- the development of arrhythmia, bradycardia or tachycardia, pulmonary embolism, myocardial infarction;
- muscle stiffness;
- ventricular coronary artery occlusion;
- frequent or difficult urination;
- decreased tonus and functioning of the gastrointestinal tract, including peristalsis (can lead to constipation);
- disorders in the central nervous system;
- dizziness and vomiting.
Drug interaction
Only the attending physician can prescribe the drug "Midrimax" to the patient. Instructions for the use of eye drops - must be read. It contains the following information about the drug interaction of this medication:
- The simultaneous use of adrenergic blocking agents (for example, Guanethidine) and reuptake inhibitors of monoamine compounds with phenylephrine can quite easily lead to a hypertensive crisis. In this regard, combining these funds is not recommended.
- The vasoconstrictor effect of phenylephrine may be enhanced in combination with β-blockers. This is due to their suppression of vasodilation.
- Potentiation of the effects of adrenergic agonists with m-anticholinergics, tricyclic antidepressants and Methyldopa is noted.
- Preliminary instillations of local anesthetics can enhance the systemic absorption of active ingredients and prolong mydriasis.
Special recommendations for using srdstva
According to the attached instructions, Midrimax eye drops contain preservatives. This fact may contribute to eye irritation, especially when wearing contact lenses.
Due to the fact that preservatives are easily absorbed by soft contact lenses, they should be removed immediately before instillation of the drug and put on after ¼ hours.
Due to a noticeable reduction in the pupil dilator, 45 minutes after the installation of the drug, particles of pigment from the pigment layer of the iris are often found in the moisture of the anterior chambers of the eyes.
Suspension in chamber moisture should be differentiated with the entry of blood elements or manifestations of anterior uveitis.
Impact on motorists and workers
Due to changes in pupil width and accommodation after using eye drops, the patient’s visual acuity can be significantly reduced. Therefore, the use of this drug is strictly prohibited when driving a car. Also, it cannot be used by people whose activities are associated with potentially dangerous work, which requires special attention and speed of psychomotor reactions.
Analogs and cost of eye drops
It is quite difficult to get Midrimax eye drops in ordinary pharmacies. Therefore, many people order them on the World Wide Web.
It should be noted that this drug has many different analogues. The following medicines can be attributed to the most similar ones (by the principle of action): Cyclomed, Midrum, Midriacil, Tropicamide, Atropine Sulfate.
Replace "Midrimax" with the listed means should only be after consultation with a doctor. This is due to the fact that they can have completely different dosages, as well as side effects and contraindications.
How much is the drug in question? Its price is quite high. You can buy one dropper bottle with 5 ml of a medicinal substance for 370-450 Russian rubles.
Reviews of patients about eye drops
Due to the fact that this drug is used only for the diagnosis of various eye diseases, as well as before surgical and laser operations, reviews about it are not very common.
From the messages that patients leave about the Midrimax drug, we can safely conclude that it is an effective ophthalmic agent that quickly and well relaxes the eye muscles.
Some experts argue that you can use this medication not only for operations and various diagnostic procedures, but also in the presence of special conditions. For example, often such drops are prescribed to patients with dry eye syndrome. However, in this case, the drug should be used in lower dosages than those presented above.