To eliminate high blood pressure and various heart diseases, beta1-blockers are used. One such drug is Betak. Instructions for use characterize it as a medicine that exhibits cardioselective, antihypertensive and sympathomimetic effects.
General characteristic
This drug is considered a synthetic beta1-blocker. It is produced by the Cypriot factory Medocemi LTD in tablet form with a white or almost white shell coating.
"Betak" medication; instructions for use; the description of the drug contains the following character: they have a rounded shape with biconvex surfaces, there is a dividing strip in the form of risks. If you break any tablet, then its internal contents will be white or almost white.
The description of consumer packaging on the Betak drug is presented as follows: one pack contains three blisters. 10 tablets are packaged in each blister strip.
Structure
In the medicine, the main role is given to the active component betaxolol in the form of a hydrochloride salt. The dosage of each tablet is 0.020 g.
For Betak, the instructions for use describe the composition of inactive ingredients without indicating their quantity. The tablets are formed by starchy sodium glycolate, milk sugar, magnesium stearate, microcrystalline cellulose, aerosil, titanium oxide, hydroxymethylpropyl cellulose and grade 400 polyethylene glycol.
Mechanism of action
For Betak medicine, instructions for use confirm cardioselective beta1 - blocking activity without internal sympathomimetic effect. Tablets exhibit weak membrane stabilizing efficacy.
Antihypertensive activity is due to actions that reduce the minute volume of the heart muscle and reduce sympathetic stimulation in the vessels around the periphery.
The selectivity of the effect of the drug on β 1 -adrenoreceptor formations cannot be called unconditional, since high doses of betaxolol can affect β 2 -adrenergic receptor formations that are located in the bronchi and blood vessels.
The blocking effect of the drug, taking into account the pharmacodynamic characteristics, is associated with a decrease in heart rate at rest and during exercise. It occurs due to inhibition of β-adrenoreceptor formations in the sinus nodes, which slows down their automatism.
Myocardial emission in the active and passive state of the body is also reduced, which is caused by the competitive antagonism of catecholamines of the nerve endings of the peripheral and adrenergic types.
The drug reduces systolic and diastolic pressure in the arteries in a calm state and during physical exertion, relieves the reflex of orthostatic increase in the frequency of heart contractions. This effect of the drug reduces the load on the myocardium.
Beta-blocker agent has antihypertensive activity according to the following mechanism:
- cardiac output decreases;
- eliminated spasm in the arteries along the periphery due to the central action, which limits the sympathetic impulse to the vascular walls during inhibition of renin activity.
Long-term prescription of the drug does not reduce its hypotensive effect. If you take a single dose of betaxolol 0.005 or 0.04 g, then a decrease in pressure will appear only after 3 or 4 hours.
The instructions for use indicate that the administration of a dose of 0.005 g will cause an antihypertensive effect, the intensity of which will be two times lower than when using a whole tablet.
The maximum hypotensive activity of any concentration of betaxolol appears after 7-14 days.
Therapeutic dosages of the drug do not cause a pronounced cardiodepressive effect, do not affect glucose metabolism, and do not increase the retention of sodium cations and fluid in the tissues.
Why use
The drug "Betak" instructions for the use of indications include the following:
- high blood pressure;
- myocardial ischemic muscle disease, myocardial infarction;
- hypertrophic cardiomyopathy.
The medicine is prescribed when there are changes in the work of the heart, which are expressed by an acceleration of the sinus rhythm, supraventricular and ventricular tachyarrhythmias, untimely myocardial depolarization, arrhythmia associated with mitral valve prolapse, excessive production of thyroid hormones.
How to use
On the medicine "Betak" the instructions for the use of the dose are painted depending on the condition of the patient. The entire daily dosage is drunk for one use. Food does not affect the absorption of the drug. The tablet should be washed down with clean water.
An increase in blood pressure is treated with a daily initial dose of 0.005 to 0.010 g. After 7 or 14 days, if necessary, the amount of medication is increased to 0.020 g.
Who should not be used
Not everyone is allowed to use Betak, the instructions for use. Contraindications are associated with excessive sensitivity to the ingredients, as well as betaxolol hydrochloride.
It is not prescribed for patients who have chronic heart failure, sinoatrial and atrioventricular blocking in the second and third degree, bradycardia, arterial hypotension, asthmatic bronchial attacks, spontaneous angina pectoris.
Betak medicines tablets are also not recommended for use in patients with cardiogenic shock, terminal vessel angiotrophoneurosis, myocardial muscle enlargement, asthenic ophthalmoplegia, endarteritis obliterans, emphysema lung tissue, chronic obstructive bronchitis, diabetes mellitus.
Explicit changes in the activity of the kidneys and psoriasis rashes are a contraindication for therapy.
Adverse reactions
Among the undesirable consequences of Betak, the instructions for use include slow heartbeat, atrioventricular blockage, heart muscle insufficiency, orthostatic pressure reduction, poor peripheral blood circulation, often cold hands and feet, paresthesia. So the work of the vascular system and heart is disrupted.
Bronchial spasm, rashes, hives, psoriasis, dry mucous membranes of the eye can cause adverse reactions of the respiratory and visual organs, skin integument.
The drug can provoke a drowsy, asthenic state, depressive disorders, excessive fatigue, confusion, signs of hallucinations, an attack of dizziness and headache.
Undesirable processes in the digestive system are associated with nausea, vomiting, diarrhea, stool retention, and cholestasis.
Other manifestations of the action of the drug can be a decrease in leukocyte and platelet blood cells, as well as a decrease in potency.
Treatment features
Taking any medication can be accompanied by certain nuances that depend on the pharmacotherapeutic group, composition and dosage of the drug used.
Betak Medication Instructions for use give specific instructions for each non-standard case that requires attention.
So at the very first stage of therapy, the appearance of insufficient work of the heart muscle in people prone to this deviation is possible.
Taking Betak tablets disguises the symptoms of a hypoglycemic state, the most important of which is heart rhythm disturbance. This knowledge should be considered in patients with high sugar levels. They need regular monitoring of blood glucose concentrations.
When using Betak medicine (tablets), the instructions for use recommend paying attention to controlling the heart rate. In the event of a bradycardic sinus rhythm disturbance, it is necessary to reduce the dosage or cancel treatment with this agent.
It requires careful use of the drug in patients with pheochromocytoma formation.
The combination of the drug with the means by which inhalation anesthesia is performed causes inhibition of the myocardial muscle and a decrease in arterial pressure. Non-depolarizing muscle relaxants exhibit a longer effect when exposed to Betak tablets.
If it is necessary to carry out a planned surgical intervention, the drug is canceled two days before this event, so that the tablets do not affect general anesthesia.
To stop treatment with Betak medication, the instructions for use advise not immediately, but in stages, with a reduction in dosage over 7 or 14 days, in order to avoid the body's reaction to drug withdrawal. Every three days, the amount of medication is reduced by 0.005 g.
Tablets are not taken with drugs that belong to monoamine oxidase enzyme inhibitors.
The antihypertensive effect of the drug reduces non-steroidal anti-inflammatory and estrogen medications that trap sodium ions and water, and also inhibit the synthesis of prostaglandin compounds inside the kidneys.
The simultaneous use of diltiazem, amiodarone and verapamil with Betak tablets leads to an increase in the inhibitory effect of betaxolol hydrochloride on the contractility of the myocardial muscle and its conductivity.
The combination of the drug with cardiac glycosidic drugs contributes to the development of blockage of the atrioventricular type.
Combination with other antihypertensive agents increases the antihypertensive activity of Betak tablets.
Cocaine decreases the therapeutic efficacy of betaxolol when administered simultaneously.
The combination of Betak tablets with adrenomimetics or xanthines causes a mutual weakening of their activity.
Phenothiazines and betaxolol hydrochloride in the interaction increase their content in the blood.
The drug "Betak" prevents the excretion of drugs containing lidocaine or theophylline.
Sulfasalazine increases the serum concentration of betaxolol hydrochloride.
There is no information on the use of the drug in pediatric patients.
Caution is required in the use of tablets for people driving a vehicle, as well as for pregnant and lactating women.
Similar means
Beta1-adrenergic blocking medication includes the Betak medicine; instructions for use. Analogs also apply to this pharmacotherapeutic class. In their composition, the active ingredient is betaxolol hydrochloride.
The French counterpart is Lokren, manufactured by Sanofi Winthrop Industry in tablet form coated with a film white. Their shape is round with biconvex surfaces on which the dividing and extruded designation “KE 20” is located.
There is a single dose of 0.02 g of betaxolol hydrochloride. Auxiliary components of the drug include milk sugar, microcrystalline cellulose, sodium carboxymethyl starch type A, colloidal silicon dioxide, magnesium stearate.
In the film coating, you can find hypromellose, 400 polyethylene glycol, titanium dioxide.
The drug is sold in cardboard packs with two blisters of 14 tablets.
A medicine is used to eliminate high blood pressure, it is also combined with other hypertension medications.
The drug can carry out preventive measures to eliminate exacerbation of angina pectoris in an intense form.
A similar drug in Russia is Betaxolol, which is produced by Moscow Endocrine Plant in the form of film-coated white tablets. They have a round shape with biconvex surfaces. Betaxolol hydrochloride in the amount of 0.020 g is considered the active ingredient. Milk sugar, sodium starch glycolate, dehydrated aerosil, magnesium stearate, and microcrystalline cellulose are auxiliary components. The film coating is formed by polyvinyl alcohol, titanium dioxide, talc, 3350 macrogol, Opadra-2 white.
This tool is used systemically with high blood pressure.
There is also a medicine called Betaxolol in the form of eye drops, which are applied topically for chronic open-angle type glaucoma, with high intraocular pressure, and when vision is restored after laser trabeculoplasty surgery.
Patient opinion
About Betak, instructions for use include reviews of undesirable effects in the section “Adverse Reactions”. These manifestations may not always occur when using a medication.
From many patients you can hear positive reviews about the beta1-adrenergic blocking drug Betak, which perfectly treats arterial hypertension and angina pectoris. Basically, tablets are taken together with other antihypertensive drugs with complex therapy, which enhance their effectiveness.
After a course of use, arterial pressure returns to normal, which greatly improves the patient's well-being.
There are also reviews about the drug, which indicate the ineffectiveness of treatment with this tool.