The drug "Parnawel" describes the instructions for use as a prodrug, which is
an ACE inhibitor and has a pronounced antihypertensive effect. The action of this agent is based on
competitive inhibition of ACE activity, which subsequently leads to a decrease in the concentration of angiotensin II. Thanks to the Parnawel medication (the instructions for use confirm this), preload, afterload (OPSS) and resistance in the pulmonary blood vessels are reduced, and load tolerance is also increased. As for the pharmacokinetic properties of this drug, a pronounced antihypertensive effect begins to be observed within the first sixty minutes after its administration, reaching its maximum after four to eight hours and lasting for a day.
The drug Parnavel is produced, the price of which varies from two hundred fifty to three hundred rubles, in the form of ordinary round tablets. The composition of one tablet as the main active element includes perindopril erbumin in the amount of four milligrams.
Parnavel recommends taking the medicine “Parnawel” exclusively for the purpose of treating a chronic form of heart failure or arterial hypertension. In this case, the initial dosage of the drug, as a rule, is one to two milligrams per day at a time, and the maintenance dosage is two to four milligrams per day.
The use of Parnawel tablets is categorically not recommended by people with individual intolerance to perindopril erbumin, as well as to all those who are predisposed to the development of angioedema. In addition, the list of direct contraindications to the appointment includes pregnancy and the age of up to eighteen years. In the lactation period, similarly, one should refrain from taking the Parnawel drug. The instruction for use notes the undesirability of its use in case of severe arterial hypertension or established renal failure. People suffering from a deficiency of fluid and sodium, before starting a course of therapy, must necessarily perform the correction of the so-called water-electrolyte disturbances.
In addition, it is necessary to use Parnawel tablets with great care at the same time as medicines, which can provoke a significant increase in potassium levels.
In conclusion, it should be said about the possible adverse reactions that may cause the use of this drug. For example, experts note a rather high risk of dry cough, headache, dizziness, taste and dry mouth. In addition, frequent mood swings, sexual dysfunctions, skin rashes, angioedema, convulsions, erythema, skin hyperemia, itching and urticaria can occur. In addition, a decrease in hemoglobin and an increase in the level of uric acid and creatinine are possible due to the use of the Parnawel drug.