"Picamilon": instructions for use, reviews, analogues

In the article, we consider the instructions for use, reviews and analogues to the drug "Picamilon".

A medication is a nootropic drug that helps to dilate blood vessels in the brain, improve cerebral circulation and the functional activity of this organ. In addition, the medication has a tranquilizing, antioxidant, psychostimulating, antiplatelet and anti-migraine effect.

Release Forms

According to the instructions to "Picamilon", the pharmaceutical dosage forms are:

1. Solutions for intramuscular and intravenous administration. Available in ampoules of 10 pieces in a cardboard box.
2. Tablets that have a flat-cylindrical shape, chamfer, white or creamy white tint. Packed in contour packs of 10 pieces - 10, 6, 3 in a cardboard box, or 30 pieces in plastic bottles, or 100, 60, 30 tablets contained in darkened glass jars.

Instructions for use with "Picamilon" are in each pack.

Structure

The active substance of the drug is the sodium salt of N-nicotinoyl-gamma-aminobutyric acid, the content of which in different dosage forms of this medication is: in 1 ml of a solution of 50 and 100 mg, and in 1 tablet - 20 and 50 mg.

Auxiliary elements of tablets are represented by potato starch, magnesium hydroxycarbonate hydrate, talc, sucrose, stearic acid and calcium stearate.

pharmachologic effect

As the instruction indicates, "Picamilon" is a nootropic medication that dilates blood vessels in the brain. It has a pronounced psychostimulating, antioxidant, tranquilizing, antiplatelet effect, and also stabilizes the tissue metabolism of this organ and affects the blood circulation in it (improves blood circulation in the capillary network, increases the blood flow in the brain, inhibits platelet aggregation, lowers vascular resistance).

With the systematic administration of this drug, the following effects are noted:

• normalization of blood circulation in the vessels of the retina and optic nerves;
• a decrease in the severity of headaches;
• normalization of sleep;
• increasing the level of mental and physical performance;
• memory improvement;
• decreased severity of tension, anxiety and fear;
• improving the general condition of patients with a variety of motor and speech pathologies;
• lowering the degree of inhibitory effect of alcohol on the central nervous system.

Pharmacokinetics

In accordance with the instructions, "Picamilon" is completely and quickly absorbed, breaking the blood-brain barrier and is stored in the tissues of the whole body for a long time. The bioavailability of the drug is from 60 to 89%. The medication is excreted mainly by the kidneys unchanged. The half-life of active substances is 30 minutes.

Indications for use

Instructions for use with "Picamilon" indicates that a pharmacological agent is prescribed in the treatment of the following pathologies:

• asthenic condition, which was the result of nervous and mental diseases;
• circulatory disturbance in the brain (acute ischemic disorders, recovery and subacute period of ischemic stroke, chronic circulatory failure of the brain);
• neuroinfection, head injuries (this drug is used as part of complex therapy);
• mental disorders, which are accompanied by increased irritability, anxiety and emotional lability;
• with the prevention of migraine;
• with open-angle glaucoma (to normalize visual function);
• with senile psychosis, as well as asthenia, vegetative-vascular dystonia, depression or other disorders in elderly patients;
• therapy of chronic alcoholism (in order to reduce the symptoms of alcoholic encephalopathy, pre-relapse, asthenic, postpsychotic and asthenoneurotic disorders);
• elimination of acute intoxication caused by excessive consumption of alcoholic beverages (usually as part of a combination treatment);
• normalization of mental and physical stress (for patients under intense or extreme conditions, athletes);
• violation of urination in all age categories of patients (to eliminate the symptoms of detrusor hypoxia and enhance the adaptive properties of the bladder).
  

Contraindications

What else does the instruction manual for Picamilon tell us? The use of this medication has some limitations. Absolute contraindications to its administration include:

• chronic renal failure;
• pregnancy and lactation;
• high sensitivity to a specific element of the drug.

Dosage and administration

According to the instructions for use with "Picamilon", solutions for intravenous administration of this medication are used drip or jet. Standard patterns for using a medicine:

• in asthenic conditions: 20 or 40 mg per day for a month with the simultaneous use of the drug in tablet form;
• in case of chronic circulatory disturbance in the brain: 100 or 200 mg per day for ten days, then intramuscularly, so that the total duration of therapy is 20 to 30 days;
• to eliminate acute uncomplicated intoxications with ethanol (as part of complex treatment): at the beginning of therapy - in saturating dosages, which are 5 mg per kilogram of the patient’s weight, and subsequently in maintenance doses.

As the instructions for use indicate, Picamilon tablets should be used orally, regardless of the time of a meal (since this does not affect the effectiveness of the drug).

Side effects

The use of a medicinal product can provoke the development of some side effects, among which some allergic reactions in the form of skin itching and rashes, disorders of the nervous system, which can occur in the form of vertigo, increased irritability, excessive anxiety, agitation, headaches, dyspepsia, can be noted.

The instruction for the Picamilon tablets is very detailed.

Overdose

With an increase in the established dosages of the drug, as a rule, an increase in the severity of side effects is noted. In this case, the patient is recommended to carry out symptomatic treatment.

This drug is prohibited for use during pregnancy and lactation.

In the treatment of children

As we are told by the instruction for use with Picamilon, it is forbidden to use it in the treatment of childhood diseases in children under three years of age.

For the treatment of children, as a rule, tablets are prescribed in a dosage of 20 mg, which is conventionally considered to be "children's". The child should swallow the tablet without chewing, washing down with clean water or any other liquid (juice, compote, milk, etc.). The duration of the therapeutic course in children with different symptoms of the disease is the same and should be from 1 to 1.5 months. If necessary, treatment can be repeated, however, the intervals between them should be strictly observed for at least three months.

According to the instructions to "Picamilon" for children, the dosage and frequency of medications are:

• at the age of 3-10 years - 20 mg twice a day;
• after 10 years - 20 mg 3 times a day;
• with therapy aimed at normalizing urination, dosages are selected by a specialist taking into account individual characteristics.

Drug interaction

With concomitant treatment with a drug with barbiturates, the duration of their exposure is significantly reduced. When used simultaneously with narcotic analgesics, their effect is enhanced.

Instructions for use with "Picamilon" confirms this.

Analogs

Analogue medicines include:

• "Olatropil", which is recommended for use to increase attention span, physical, mental performance, learning and memory, to reduce irritability and increase the body's resistance to stressful effects of various origins, for diseases of the nervous system caused by vascular changes (atherosclerosis, hypertension), chronic cerebral -vascular insufficiency, for the treatment of the consequences of stroke and head injury, in order to restore speech, increase mental activity, prevent an attack dizziness, in depressive states with signs of adynamia, etc.
• “Citimax” is a medication that is used in the acute phase of circulatory disorders in the brain and the treatment of their consequences, with brain injuries, various neurological disorders (sensitive, cognitive, motor) caused by cerebral pathology of degenerative and vascular origin. This is stated in the instructions for use with the Picamilon analogue.
• “Noofen” - is used in case of asthenic, neurotic and anxiety states, stuttering, enuresis in children, insomnia and night anxiety symptoms in elderly people, with Meniere’s disease, dizziness associated with vestibular analyzer dysfunction, in the prevention of motion sickness, as part of a comprehensive treatment for withdrawal syndrome to eliminate somatovegetative and psychopathological disorders.
• “Pantogam” is a medication prescribed for children with severe perinatal encephalopathy, cerebral palsy, mental retardation of varying severity, with behavioral disorders, developmental delay, speech and motor function disorders, the formation of learning skills, as well as hyperkinetic disorders, neurosis-like conditions, and stuttering , enuresis and encopresis, with a decrease in intellectual productivity, senile dementia, brain damage, etc. Detailed instructions for analogues of Picamilon we will not attack.
• “Pantocalcin” - is prescribed for cognitive impairment, akinetic and hyperkinetic neuroleptic syndrome, for schizophrenia, treatment of cerebrovascular insufficiency, for the effects of encephalitis and neuroinfection, head injuries, trigeminal neuralgia, diseases of the nervous system, cervical osteochondrosis.
• "Semax" - is prescribed for intellectual and mnestic disorders, for vascular diseases of the brain, encephalopathy, neurotic disorders, after ionizing radiation, stroke, etc.
  

Reviews

This drug is widely used in the field of clinical neurology. It is prescribed for many functional and pathological disorders in the work of the brain, with cerebrovascular insufficiency, neuralgia in adults, developmental delay in children. In addition, it can be used for depressive disorders associated with insufficient intake of oxygen in the brain, with pathologies of the vascular system, etc. There is information on this in the instructions.

Reviews about Picamilon are mostly positive. Patients note that during treatment with this medication they significantly improved physical well-being, mental activity, psychological state and quality of sleep. They observed increased attention, the disappearance of distraction, symptoms of chronic fatigue, etc. In addition, patients showed a significant improvement in the quality of visual functions, hearing, etc.

Parents of children to whom this drug was prescribed for some brain pathologies, including at very early stages of life, say that the child’s condition improved, but this was not noticeable immediately, but after a long period of about one to two months. In older children, there was an improvement in memory and memorization, significant changes were noted regarding the educational process. In addition, parents indicate a good tolerability of this drug. In rare cases, children developed symptoms of increased drowsiness, or, conversely, increased mental arousal, however, these phenomena disappeared after the initial period of therapy.

We reviewed the instructions for use with Picamilon.