"Prednisolone" is a hormonal medication for local and systemic use of medium duration. The drug is a dehydrogenated substitute for the hormone hydrocortisone produced by the adrenal cortex. The activity of the drug is many times higher. To purchase the drug, you need an appointment. Write a prescription in Latin for "Prednisolone" can a doctor.
The drug prevents the occurrence of an allergic reaction, inhibits the activity of immunity, eliminates the inflammatory process, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines, and has an anti-shock effect.
Release form
The Latin name for Prednisolone is Prednisolone. The drug is produced in several dosage forms: solution, tablets, ointment and drops.
The composition of Prednisolone in ampoules includes:
- active substance;
- sodium pyrosulphate;
- disodium edetate;
- nicotinamide;
- sodium hydroxide;
- water.
In ampoules "Prednisolone" (recipe in Latin):
Rp .: Sol. Prednisoloni 0.025 - 1 ml
D. td No. 1 in ampull.
S: Inject from 20 ml. 0.9% sodium chloride solution intravenously.
The structure of the tablets includes the following substances:
- active substance;
- colloidal silicon dioxide;
- magnesium stearate;
- stearic acid;
- starch;
- talc;
- lactose monohydrate.
Recipe "Prednisolone" in Latin (in tablets):
Rp .: Prednisoloni 0.001 (0.005)
DtdN 50 in tab.
- 1-2 tab. 2-3 times a day.
The liniment includes:
- active substance;
- soft paraffin;
- glycerol;
- stearic acid;
- methyl and propyl parahydroxybenzoate;
- water.
Indications for use
"Prednisolone" is prescribed in the presence of the following deviations and diseases:
- Atopic dermatitis (chronic allergic dermatitis develops in individuals with a predisposition to atopy, has a repeated course).
- Contact dermatitis (a generic term for acute and chronic diseases that occur as a result of skin contact with substances with an irritating effect).
- Pollinosis (a seasonal disease caused by hypersensitivity to pollen of various plants, which manifests itself by redness).
- Urticaria (the name of a group of diseases characterized by the appearance of acutely itching, inflamed rashes on the skin, mucous membranes).
- Quincke's edema (a reaction to the effects of various biological and chemical factors, often of an allergic nature).
- Minor chorea (a neurological disorder accompanied by promiscuous muscle contractions and motor impairment).
- Rheumatic fever (a disease of connective tissue with localization of lesions in the heart and blood vessels).
- Rheumatic heart disease (an ailment that affects the walls and membranes of the heart, as a result of which the normal functioning of the organ is disrupted).
- Nonspecific tendosynovitis (an inflammatory process that affects the synovial lining of the tendons, accompanied by pain and tenosynovitis).
- Seronegative spondylitis (a disease that is associated with inflammation and damage to the joints, as well as the spine).
- Epicondylitis (degenerative and inflammatory tissue lesions in the elbow joint).
- Osteoarthritis (a disease of the musculoskeletal system that affects large and small joints of the arms and legs).
- Lung cancer.
- Fibrosis (proliferation of connective tissue with the appearance of cicatricial changes in various organs, which occurs, as a rule, as a result of chronic inflammation).
- Acute alveolitis (post-traumatic infection and inflammation of the tooth hole after tooth extraction).
- Sarcoidosis (benign systemic disease, which belongs to the group of granulomatous processes, affects individual tissues of the body).
What other indications for use does Prednisolone have?
The drug is prescribed for:
- Eosinophilic pneumonia (a rare disease in which blood and lung tissue are affected by eosinophils).
- Aspiration pneumonia (an acute infectious toxic inflammatory process in the lung tissue that occurs due to the contents of the stomach, nasopharynx or oral cavity entering the lower respiratory tract. The disease is common).
- Tuberculous meningitis (inflammation of the meninges provoked by the ingress and activation of tuberculous bacteria).
- Pulmonary tuberculosis (an infectious disease that is provoked by Koch bacillus and is characterized by various lesions of the lung tissue).
- Granulomatous thyroiditis (an inflammatory lesion of the endocrine system, in which the destruction of gland cells occurs due to the action of the virus).
- Autoimmune diseases (pathologies that occur when the protective forces of the body fail).
- Hepatitis (inflammatory liver disease, usually of viral origin).
- Inflammatory diseases of the gastrointestinal tract.
- Nephrotic syndrome (a non-specific complex of clinical and laboratory symptoms that occurs with inflammation of the kidneys and manifested by edema, the appearance of protein in the urine and its low content in blood plasma).
- Anemia (a pathological condition of the body in which there is a decrease in the number of hemoglobin and red blood cells below the lower normal range).
- Cerebral edema.
- Dühring’s disease (a chronic, recurring bullous skin disease belonging to the group of immunopathies, characterized by polymorphism of skin manifestations and itching of the skin).
- Psoriasis (a chronic non-infectious disease, dermatosis that affects mainly the skin).
- Eczema (non-infectious inflammatory lesion of the skin, which is characterized by a variety of rashes, burning, itching and a tendency to repeat).
- Pemphigus (severe skin disease associated with impaired immunity).
- Exfoliative dermatitis (various lesions of the skin, which are extensive in nature and are characterized by enhanced peeling).
- Uveitis (an inflammatory process in the choroid).
- Allergic ulcerative keratitis (an inflammatory change in the cornea (cornea) of the eye associated with the development of an acute allergic reaction).
- Allergic conjunctivitis (the appearance of an inflammatory reaction of the mucous membrane of the eye in response to exposure to allergens).
- Choroiditis (inflammation of the choroid itself).
- Iridocyclitis (inflammation of the iris and ciliary body of the eyeball).
- Non-purulent keratitis (diseases that include many conditions of various etiologies).
Indications for the introduction of the solution:
- An acute attack of food allergies.
- Anaphylactic shock (immediate allergy, state of increased sensitivity of the body).
After several days of parenteral administration, the patient is usually transferred to a tablet form.
Indications for the use of tablets are considered to be chronic pathological processes. The prescription for Prednisolone in ampoules in Latin will be written by a medical specialist, since the drug is dispensed in the presence of a special purpose.
In addition, the solution and tablets of the drug are used to prevent transplant rejection and eliminate nausea or vomiting in people receiving cytostatics.
Ointment "Prednisolone"
As an external remedy, liniment is used for allergies and for eliminating inflammatory skin diseases of non-microbial origin. For instance:
- Dermatitis (an inflammatory lesion of the skin resulting from exposure to damaging factors of a chemical, physical or biological nature).
- Discoid lupus erythematosus (an unpleasant and incomprehensible disease by origin, one of the subspecies of lupus that affects the skin, but does not affect the internal organs, compared with a more severe form).
- Psoriasis (a chronic non-infectious disease, dermatosis, mainly affecting the skin).
- Urticaria (skin disease, dermatitis of predominantly allergic origin, characterized by the rapid onset of severely itchy blisters).
Eye drops
"Prednisolone" is also prescribed to eliminate eye diseases:
- Iridocyclitis (inflammation of the iris and ciliary body of the eyeball).
- Keratitis (inflammation of the cornea of the eye, manifested mainly by its clouding, ulceration, pain and redness of the eye).
- Scleritis (an inflammatory disease that affects the entire thickness of the outer connective tissue membrane of the eyeball).
- Blepharoconjunctivitis (inflammation of the edges of the eyelids in combination with lesions of the palpebral and orbital conjunctiva).
- Sympathetic ophthalmia (binocular damage to the organ of vision, developing after damage to the uveal tract with subsequent involvement in the pathological process of the second intact eyeball).
Drug limitations
According to the instructions for use, it is known that the main contraindications to the use of the drug are:
- Herpesvirus infection (primary infection with the herpes virus, capable of transitioning from a latent state to an active state due to stress, decreased immunity, hypothermia, overwork).
- Amoebiasis (anthroponous infestation with fecal-oral transmission mechanism, which is characterized by chronic recurrent colitis with extraintestinal manifestations).
- Tuberculosis (a contagious infectious disease, the main cause of which is infection of the body with Koch sticks).
- Systemic mycosis (diseases of a fungal nature, accompanied by damage to the skin, internal organs and mucous membranes).
- Duodenal ulcer (a chronic disease with a relapsing course that affects the mucous membrane).
- Myocardial infarction (one of the clinical forms of coronary heart disease occurring with the development of ischemic necrosis of the site).
- Hyperlipidemia (abnormally elevated levels of lipids and / or lipoproteins in human blood).
- HIV (a disease caused by the human immunodeficiency virus).
- AIDS (a disease that is considered one of the worst diseases of modern civilization).
- Lymphadenitis (an inflammatory disease of the nodes of the lymphatic system is often purulent in nature).
- Itsenko-Cushing's disease (a neuroendocrine disease characterized by increased production of hormones of the adrenal cortex, which is caused by excessive secretion of ACTH by the cells of the hyperplastic pituitary tissue).
- Kidney and liver disease.
- Urolithiasis disease.
- Systemic osteoporosis (severe chronic disease of bone tissue, characterized by a decrease in its density).
- Poliomyelitis (cerebrospinal paralysis, which is caused by damage to the gray matter of the spinal cord by poliovirus and is characterized by pathology of the central nervous system).
- Acute psychosis (a pronounced violation of mental activity in which mental reactions are grossly contrary to the real situation (according to I.P. Pavlov), which is reflected in a disorder in the perception of the real world and disorganization of behavior).
- Myasthenia gravis (an autoimmune nervous and muscle lesion characterized by pathologically rapid fatigability of striated muscles).
- Lactation.
- Pregnancy.
Contraindications to the introduction of the solution are:
- Pathological bleeding.
- Severe deformation of the joint.
- Bone destruction.
- Periarticular osteoporosis (a disease of the skeleton consisting in the destruction of joints and bones in contact with them).
- Pregnancy.
According to the instructions for use, it is known that liniment cannot be applied to the skin with:
- Mycosis (an ailment of fungal nature that affects the skin, nails, feet, scalp and inguinal region).
- Viral and bacterial skin lesions.
- Cutaneous manifestations of syphilis.
- Tumors of the skin.
- Tuberculosis (a chronic infection caused by mycobacteria).
- Acne.
- Pregnancy
Can be purchased with a prescription ointment "Prednisolone" in Latin:
Rp .: Ung. Prednisoloni 0.5% DS
Apply to affected areas 1 to 2 times a day.
According to the instructions for use, it is known that eye drops are not recommended for use with:
- Fungal and viral lesions of the eyes.
- Trachoma (an infectious lesion of the organs of vision that is provoked by chlamydia and is characterized by damage to the conjunctiva and cornea with the outcome in scarring of the conjunctiva, cartilage of the eyelids and complete blindness).
- Acute purulent viral conjunctivitis.
- Purulent infection of the eyelids and mucous membrane.
- Purulent ulcer of the cornea.
- Tuberculosis of the eyes (extrapulmonary form of tuberculosis, in which its own choroid, conjunctiva or adnexa of the organ of vision is affected)
Adverse reactions
Like any other drug, Prednisolone is able to provoke the appearance of the following negative effects:
- Fluid and sodium retention in the body.
- The development of nitrogen deficiency.
- Hypokalemic alkalosis (a change in the acid-base balance of the internal environment associated with the accumulation of hydroxyl anions).
- Glucosuria (the presence of glucose in the urine).
- Hyperglycemia (a clinical symptom indicating an increase in serum glucose compared to normal).
- Weight gain.
- Cushing's Syndrome (a complex of clinical symptoms due to the high content of corticosteroids in the blood).
- Steroid myopathy.
- Muscle weakness.
- Muscle loss.
- Osteoporosis (a chronic and progressive systemic metabolic lesion of the skeleton or clinical syndrome, which manifests itself in other diseases characterized by a decrease in bone density).
- Esophagitis ulcer (a disease of the esophagus, which is characterized by the development of an inflammatory process on its mucosa, namely erosion and ulcers).
- Flatulence.
- Digestive disorders.
- Vomiting
- Nausea
- Increased appetite.
- Pancreatitis (inflammation in the pancreas, in which there is a deficiency in the production of pancreatic enzymes).
- The appearance of blackheads.
What other undesirable reactions does the drug provoke?
Prednisone causes:
- Thinning of the skin.
- Erythema.
- Pseudotumor syndrome (clinical syndrome: increased intracranial pressure that occurs in the absence of intracranial volume formation or hydrocephalus).
- Depression
- Hallucinations.
- Petechiae (point rashes on the skin, which are no more than three millimeters, hemorrhagic in nature, having the shape of a circle).
- Diplopia (ophthalmic pathology associated with double vision).
- Vertigo (a symptom known as dizziness, it is characteristic of ear pathology or, less commonly, brain damage).
- Loss of sleep.
- Headaches.
- Glaucoma
- General weakness.
- Fainting.
- Teleangiectasia (a chronic increase in the diameter of small capillaries on the surface of the skin, manifested in the form of a vascular network or asterisks).
- Purples.
- Steroid Acne.
- Burning.
- Dryness.
- Hypertrichosis (a disease manifested in excessive hair growth that is not characteristic of a given area of the skin that does not correspond to gender and / or age).
Instructions for use
The prednisolone solution is administered intravenously, as well as intramuscularly and intraarticularly.
The method of administration and dosage of the drug are selected individually, taking into account the type of pathological process, the severity of the patient's condition, the location of the affected organ.
In severe conditions, the patient is prescribed pulse therapy using for a short time high concentrations of the drug. For 3-5 days, he is injected with 1-2 grams of medication every day by intravenous drip infusion. The duration of the procedure is from half an hour to 1 hour.
During therapy, the dosage is adjusted depending on the condition of the patient. It is considered optimal to administer the solution intravenously. For intra-articular administration, Prednisolone is used only in situations where the tissue inside the joint is affected by the pathological process.
Positive dynamics is considered the basis for the transfer of the patient to the tablet form. Therapy with tablets is continued until persistent remission.
If it is impossible to administer Prednisone intravenously, the drug must be injected deep into the muscle. But keep in mind that with this method it is absorbed more slowly.
Depending on the pathological process, the dosage of Prednisone may vary from 30 to 1200 milligrams per day.
Children from two months to one year are administered from 2 to 3 milligrams per kilogram of weight. The dose of Prednisolone for children from one to 14 years old is 1-2 milligrams per kilogram of body weight (as a slow intramuscular injection). If necessary, after half an hour, the drug is re-administered in the same concentration.
If a large joint is damaged, 25 to 50 milligrams of the drug is injected into it. From 10 to 25 mg are injected into medium-sized joints, and from 5 to 10 milligrams into small joints.
Terms of sale and storage
To buy the drug you need to have a special purpose. Recipe "Prednisolone" in Latin in ampoules (for v / m administration to a child up to a year):
Rp: Sol. Prednisoloni hydrochloride 3% - 1.0
Dtd N 3 in amp.
S. i / m 0.7 ml (i / m - 2 mg / kg / day; i / v - 5 mg / kg / day).
Ointment must be stored from 5 to 15 degrees heat, tablets and solution - at a temperature of up to 25 degrees, eye drops - from 15 to 25 degrees.
The doctor will give a prescription for the prednisolone solution in Latin. Drops after opening the bottle should be used within 28 days. For ointment, as well as tablets and solution - 24 months, for eye drops - 36 months.