Calcium channel blockers are called a heterogeneous group of drugs that have the same principle of action, but differ in some properties, including kinetic parameters, tissue selectivity and effect on heart rate.
The basic principle of the action of such medicines is that they are able to inhibit the penetration of Ca ions from the intercellular space into the vessels and muscle cells of the heart through calcium channels (slow). This leads to a pronounced vasodilating effect.
The most popular calcium antagonist is Cinarin. Instructions for use, cost, reviews and composition of this tool will be described below.
Release form, packaging, description, composition
The drug “Tsinarin”, reviews of which are positive, goes on sale in the form of biconvex, round and white tablets. Their main component is cinnarizine. In addition to it, the composition of the medicine includes excipients in the form of povidone K25, lactose, wheat starch, colloidal silicon dioxide and magnesium stearate.
You can buy this tool in contour cells.
Drug characteristics
Instructions for use of the drug "Cinarin" reports that it is a selective antagonist of calcium channels (slow). It reduces the intake of Ca ions into cells and reduces their number in the plasma membrane depot, and also enhances the vasodilating effect of carbon dioxide and reduces the tone of the muscles of the arterioles.
By acting directly on the vessels, this drug significantly reduces their response to nutrients (norepinephrine, adrenaline, angiotensin, dopamine and vasopressin). It should also be noted that the medication in question has vasodilating properties, including in relation to the vessels of the brain. However, it does not affect blood pressure.
The drug “Tsinarin”, the price of which is indicated below, exhibits a moderate antihistamine activity, reduces the excitability of the vestibular apparatus and reduces the tone of the sympathetic NS. This drug effectively manifests itself both in the initial cerebrovascular insufficiency, and in chronic. In people with impaired peripheral circulation, it improves blood circulation to all tissues and organs. Also, this tool reduces blood viscosity, increases the elasticity of red blood cell membranes and muscle resistance to hypoxia.
Kinetics of medication
What kinetic features are inherent in the drug “Tsinarin”? Instructions for use states that this drug is absorbed in the intestines and stomach. The peak of its concentration in plasma is reached after three hours. The relationship of cinnarizine with plasma proteins is 91%. The drug is completely metabolized in the liver. Its half-life is four hours. A medication with urine and feces comes out.
Indications
The drug "Cinarin" is indicated for use with:
- senile dementia;
- ischemic stroke;
- cranial injuries;
- post-stroke conditions (including hemorrhagic stroke);
- discirculatory encephalopathy;
- for the prevention of kinetosis (sea or air sickness, as well as motion sickness);
- vestibular disorders (including Meniere’s disease, tinnitus, dizziness, nystagmus, vomiting and nausea of labyrinth origin);
- migraines (for the prevention of seizures);
- impaired peripheral circulation.
Contraindications to taking pills
Under what conditions can the drug “Cinarin” not be prescribed? The instruction for use reports that this tool is contraindicated in:
- hypersensitivity;
- bearing the fetus;
- breastfeeding.
It should also be noted that this medicine is prescribed with caution in Parkinson's disease.
The drug "Cinarin": instructions for use
Take the pills in question should be inside, preferably after a meal.
In case of impaired blood circulation of the brain, the drug is prescribed in an amount of 25-50 mg three times a day, and in case of impaired peripheral circulation - 50-75 mg with the same multiplicity.
For vestibular disorders, the drug is recommended to take 25 mg three times a day. With kinetosis or the so-called "road" disease, adult patients are prescribed 25 mg of the drug 30 minutes before the road. If required, then the medicine is taken again after 6 hours (in the same amount).
For children, this drug is prescribed in the amount of 1/2 dose from an adult.
With high sensitivity to the medication, therapy begins with a half dosage, gradually increasing it. The course of treatment can last from 2-3 weeks to several months.
Side effects
This drug may cause the following adverse reactions:
- dry mouth, dyspepsia, epigastric pain, cholestatic jaundice;
- drowsiness, headaches, fatigue and extrapyramidal disorders (for example, increased muscle tone, tremor of the extremities, hypokinesia);
- lichen planus, sweating, lupus-like syndrome, skin rash;
- allergic phenomena, weight gain, decreased blood pressure.
Price, release of the drug, analogues and reviews about it
The release of medicines belonging to the group of calcium channel blockers is carried out on prescription. The price of this medicine is about 20-50 rubles.
If necessary, this tool can be replaced with drugs: Vertisin, Diziron, Stugezin, Stugeron, Cinazin, Cinedil, Cinnarizine, etc.
Most consumers who take this antagonist claim that it is a very effective and effective drug. Reception of tablets "Tsinarin" helps to eliminate vestibular disorders and disorders in the blood circulation. In addition, this medication has a positive effect on the human body with migraines, senile dementia and post-stroke conditions.
It should be noted that the agent in question often causes adverse reactions. In order to avoid their development, all doctor's recommendations should be strictly observed. It is forbidden to take Cinarin tablets at your own discretion. They should be prescribed only by the attending physician.