Over the past few years, proteolytic enzymes for enzyme therapy, such as Chymotrypsin and Trypsin, have been very popular. Instructions for use informs that these drugs are prescribed for ophthalmic pathologies. These enzymes were first isolated by an American biochemist and professor John Howard in experimental animals. They are produced by the pancreas of cattle and mammals. They are activated under the influence of enterokinase and trypsin.
Through repeated studies, scientists have come to the conclusion that proteolytic enzymes can be effectively used in ophthalmology (as an antibacterial, anti-inflammatory and decongestant) for the treatment of extraction of cataracts, uveitis, post-traumatic eyelid disorders, central retinal vein thrombosis, subluxation of the lens, iridocyclitis and pus. channels.
It should be noted that overdose with a different method of use was not detected. But despite a fairly wide range of applications, the release of these medicinal drugs was suspended during the collapse of the USSR. Now the production is again established in Ukraine by the Kiev company, which manufactures bacterial agents under the brand name "Biopharma".
How are they issued?
The preparations “Trypsin” and “Chymotrypsin” are currently produced in the form of a lyophilized crystalline white powder, which does not have any odor. It is easily soluble in saline and ordinary water. In ophthalmologic clinics, medicines are used for subconjunctival, intramuscular and intravenous injections.
They are also used in the form of inhalations, dusting and baths. Electrophoresis is also widely used to treat most diseases. This method of administration gives effective results at low dosages, unlike other methods of administration. It is scientifically proven that the activity of enzymes does not decrease even under the influence of current.
This technique allows you to successfully treat hemorrhage in the eyeballs, as well as degenerative-dystrophic, adhesive and inflammatory processes. The drug "Trypsin", the instructions for use of which recommends it for therapeutic purposes in retinal hemorrhages, is also used for chorioretinitis, retinal degeneration, endophthalmitis and atrophic processes of the optic nerve.
What function does trypsin have in the human body?
The enzyme is involved in the cleavage of peptides and hydrolysis of proteins into simpler elements. Our pancreas system produces the crystalline substance in the form of trypsinogen (inactive state of the enzyme). After it enters the duodenum, trypsin is activated by the enzyme enteropeptidase and bile. Pathological violations of the gland are indicated by the absence of this substance in the feces. Trypsin in feces may also not be detected with pancreatic fibrosis.
Increase and decrease in the activity of the enzyme in the blood, what does it mean?
It is rarely found in patients with malignant tumors and viral infections. Serum activity is usually reduced in people with cancer of the gland, chronic pancreatitis, cystic fibrosis, and diabetes. If suspected of these pathologies, the drug Trypsin (crystalline) is prescribed.
Pharmacology of the drug
It is an anti-inflammatory agent that helps thin out viscous sputum. Breaks down fibrinous neoplasms and dead tissue. It is proved that the medicine does not have a detrimental effect on hemostasis.
What diseases are prescribed Trypsin?
Instructions for use clearly indicate that this medicine eliminates respiratory system diseases: bronchitis, pneumonia, tracheitis, pleural empyema, postoperative lung atelectasis, and exudative pleurisy. In addition, the medication is prescribed by doctors to treat periodontal disease, osteomyelitis, thrombophlebitis, iridocyclitis, sinusitis and otitis media. The drug helps with injuries, pressure sores, burns and purulent wounds.
Mode of application
A solution of crystalline trypsin is used in several ways.
In the form of electrophoresis, aerosol, intravenous and intrapleural. The duration of therapy is usually from 6 to 15 injections. Before use (for adults), 0.005 g of the substance is dissolved in a sterile solution of sodium chloride (0.9%) or procaine.
For wounds and burns, compresses are applied topically (in the form of a trypsin solution or powder). Before dressing, 50 mg of the substance is diluted in 5 ml of sodium chloride or sterile water. The wound is treated, and then a compress is applied for two days. Periodically, the dressing is moistened with an antiseptic, since dry gauze will not give the desired effect. If after 24 days the wound did not heal, then the procedure is repeated.
In the form of drops: a medicine is made from a 0.2-0.25% solution.
In the form of inhalation: the drug is administered using a bronchoscope or medical inhaler. After the procedure, the oral cavity is rinsed, and the nasal passages are washed with sterile water.
Side effects
In rare cases, allergic reactions are possible. With the inhalation route of administration, hoarseness of the vocal cords, irritation and redness of the mucous membrane of the respiratory tract can be observed. With intravenous administration, hyperemia at the injection site, slight redness and soreness are detected in patients.
Contraindications
It is forbidden to introduce the Trypsin preparation into the bleeding surface. Instructions for use warns that you can not apply compresses to the indicated area of malignant tumors. The drug is contraindicated for dystrophy and cirrhosis of the liver, pancreatitis, hemorrhagic diathesis and infectious hepatitis. Also not used for bronchial asthma, emphysema and acute forms of tuberculosis. People with hypersensitivity should be replaced with another medicine.
Storage conditions
Sold by prescription only. Before buying, be sure to look at its expiration date (no more than three years). It is better to store the medicine in the refrigerator - in the door, or in a cool, dry place, protected from sunlight at a temperature of no higher than + 10 ° C. The price policy ranges from 400 rubles for ten ampoules.
Similar drugs
These include Pax-trypsin, Terridekase, Ribonuclease, Asperase, Lizoamidase, Dalcex and Profesim. Only in ampoules the Trypsin medication is available. An ointment based on this substance is called "Irukson."
Conclusion
In medical practice, the proteolytic enzymes Trypsin and Chymotrypsin have established themselves as highly effective agents in the fight against many pathologies. They are widely used by most ophthalmological institutions for the treatment of small hemorrhages, mooring and adhesions, since such processes with improper therapy can lead to severe pathologies (before loss of vision).
Today, the use of enzymes in combination with modern antibacterial, antihistamines, anti-glaucoma and hormonal drugs significantly increases the effectiveness of the treatment of eye diseases. The description and instructions are presented for informational purposes; to prescribe a medication yourself is dangerous to health. We recommend that you contact your physician for an accurate diagnosis of the disease. He will also find out if you are allergic to this medication.
Patient opinions
Most people who have tried this medicine on themselves speak enthusiastically about it. It made it possible for some to recover faster and to stand up. It helps to cope with joint diseases: it removes soreness, relieves inflammation and restores motor function. Many patients are very treated with the Trypsin medication.
Reviews in a positive way about this drug are often numerous. Indispensable for severe cuts and injuries. After applying the compress, swelling, redness decreases and tissue regeneration occurs faster. None of the patients expressed dissatisfaction.
Doctors and specialists themselves praise the product and consider it versatile and highly effective. With it, you can achieve an amazing therapeutic result. Inhalation of Trypsin solution helped many patients with diseases of the respiratory system. In a couple of days, severe symptoms disappear, a person feels a surge of strength.
Patients taking this medicine were satisfied, as were the medical staff who prescribed it for treatment. Proteolytic enzymes show effective results in many areas. Take care of your health and take a course of therapy in a timely manner.