The drug "Progestogel" application instruction refers to the clinical and pharmacological group of drugs used externally for the treatment of mastodynia.
It is produced in the form of a one percent colorless gel (there are no visible particles in it), which has a smell of alcohol.
The active ingredient of the drug is natural micronized progesterone. Among the auxiliary ones are trolamine, distilled water, ethanol, carbomer 980, octyldodecanol, castor oil.
The drug "Progestogel", instructions for use informs, has a therapeutic effect due to the action of progesterone. This substance blocks estrogen receptors, due to which compression in the milk ducts is reduced, and the process of fluid absorption from tissues is also improved. In addition, prolactin receptors are blocked in breast tissue, which reduces lactopoiesis.
The drug "Progestogel", the instructions for use contain this information, with local use it causes a high content of the main active substance in the field of application. In this case, there is no systemic effect and no side effects.
The drug "Progestogel", the use of which eliminates mastodynia, inhibits tubular reabsorption and increases cellular filtration. This prevents fluid retention during conversion of the secretion of the glandular component in the mammary glands.
The transdermal type of use of the drug allows you to affect the vascular network and glandular epithelium. Due to this, the permeability of capillaries decreases, swelling of tissues in the mammary gland, the signs of mastalgia disappear.
The drug "Progestogel", the instruction for use of which recommends a transdermal method of use, is able to reach the tissues of a diseased organ without exerting undesirable effects on the body and without being destroyed in the liver.
Absorbency of the main active ingredient with appropriate application is ten percent of the applied volume. The most complete absorption in the skin is observed an hour after using the drug. In this case, the level of hormones does not undergo changes.
According to studies, the medication in question is mostly excreted in the urine (up to sixty percent), a small amount leaves the body along with bile.
An indication for the use of this drug is mastodynia, the occurrence of which is due to the use of contraceptives (oral), the presence of premenstrual tension syndrome, mastopathy, and pregnancy. In addition, the drug is used to treat fibrocystic mastopathy.
Medication "Progestogel." How to apply?
A small amount (about two and a half grams) of the gel is applied using a metering applicator to problem areas until the drug is completely absorbed. The procedure is repeated daily several times a day, or from the sixteenth to twenty-fifth day of the menstrual cycle (its second phase).
The course of treatment can last up to three cycles. Repeatedly it can be carried out only by agreement with a specialist.
Possible side effects: the manifestation of various allergic reactions - swelling of the lips or neck, the occurrence of fever, erythema in the area of application of the gel, headache and nausea. Metrorrhagia, decreased libido, pain in the mammary glands are extremely rare.
The drug is contraindicated in case of nodular forms of fibrocystic mastopathy, tumors or tumor formations of unknown origin, genital cancer monotherapy, in the second and third trimester of pregnancy, as well as in case of hypersensitivity to the components included in the Progestogel medication.