"Baclofen" is a drug that has a powerful effect on neuromuscular transmission of impulses. In addition, the medication has a strong sedative effect. The dosage is selected for each person purely individually: so that the medication has an antispastic effect, but does not lead to adverse reactions.
Pharmacological properties
Taking the drug can lead to the following effects on the patient's body:
- relaxing
- antispastic;
- painkiller.
According to the instructions for the use of "Baclofen" it is known that the medicine adversely affects the reflexes of spinal cord extension, and also significantly reduces muscle tone.
From the stomach and intestines, Baclofen, according to people, is perfectly absorbed. After consumption, the drug reaches its maximum concentration in the body after three hours. The drug is excreted through the kidneys with urine.
Composition and form of release
The medication is made in tablet form at ten and twenty-five milligrams. It is known from the instructions for use: "Baclofen" is not available in injections. The composition of the drug has one active substance - baclofen. Tablets are packaged in fifty bottles.
Indications
The main indications for the use of "Baclofen" are the following diseases:
- Multiple sclerosis (a chronic autoimmune disease in which the myelin sheath of the nerve fibers of the brain and spinal cord is affected).
- Paralytic syndromes (complete absence of voluntary movements).
- The defeat of the brain.
- Stroke (an acute violation of the microcirculation of the brain that provokes damage and death of nerve cells).
- Cerebral palsy (a general medical term used to refer to a group of motor disorders).
- Heart attack (death of the heart muscle, the cause of which is a violation of blood circulation).
Tablets "Baclofen": instructions for use
The product must be consumed with food. Initially, the dosage of "Baclofen" for adult patients and children is fifteen mg per day.
One serving of the drug is equal to half a tablet of ten milligrams. Every three days, the amount of medication rises. This should occur gradually so as not to cause poisoning.
The therapy is carried out under the supervision of a medical specialist, with strict observance of the instructions for use of Baclofen. According to patients' reviews, it is known that dosing is increased until the necessary therapeutic effect is obtained.
Typically, for an adult patient, the maximum concentration of the active substance varies from thirty to seventy-five mg per day. When using the drug in high doses, you need to take "Baclofen" one time in an amount of twenty-five milligrams.
Nevertheless, according to medical reviews and instructions for the use of baclofen tablets, it is known that the maximum daily dose of the drug should not be more than one hundred mg. For small patients from one to two years, as a rule, not more than twenty milligrams per day is prescribed.
The daily dosage of "Baclofen" for babies from two to six years is from twenty to thirty mg.
Children from six to ten years old are allowed to take the drug in the amount of thirty to sixty milligrams. And after ten years, another Baclofen treatment regimen is used according to the instructions for use: based on the body weight of the child.
So, at this age, it is recommended to use the drug at the rate of one and a half to two milligrams per kilogram.
Cautious use of "Baclofen"
Reviews about the drug tell that the drug should be used with extreme caution in the following ailments and conditions:
- Kidney and liver disease.
- An acute violation of the microcirculation of blood in the brain, leading to damage and death of nerve cells.
- Respiratory diseases.
- Neurogenic dysfunction.
- The symbol for pathologies leading to organic brain damage.
- Schizophrenia (a mental state characterized by a distortion of consciousness and perception).
- Cramping.
- Dizziness, in which different syndromes are combined (amentia and delirium).
In the presence of these conditions, it is recommended to use the medicine with extreme caution, according to the instructions for use. Reviews about the drug "Baclofen" sometimes contain information about the negative consequences of the use of the drug by patients of retirement age. Therefore, people over sixty-five years old need to be very careful about taking the medicine.
After the treatment, according to the instructions for use of "Baclofen", you need to slowly lower the amount of active substance. From reviews of the drug it is known that a sharp dose reduction can provoke the following problems:
- Spasm.
- Restless condition.
- Anxiety (negatively colored emotion expressing a feeling of uncertainty, hard-to-detect forebodings).
- Hallucinations (an image that occurs in the mind without an external stimulus).
- Mental illness.
- Increased muscle tone.
Using "Baclofen" can adversely affect attention, therefore, at this time it is not advised to drive. It is best to take a vacation or carry out treatment within the walls of the hospital during the procedure.
Adverse reactions
Due to the fact that the medication has a strong effect, the appearance of negative effects of the effects of the drug is quite possible. This probability increases due to improper compliance with the instructions for use of "Baclofen." So, adverse reactions from the use of the drug can be very different.
For example, the following negative phenomena may appear from the side of the nervous system:
- Drowsiness.
- Insomnia (sleep disorders).
- Dizziness.
- Migraine (a neurological disease characterized by episodic or regular severe pain).
- Dull consciousness.
- Ataxia (a motor disorder that is accompanied by impaired coordination of movements).
- A pathology that is characterized by a motor disorder of varying degrees.
- A state of euphoria (positively colored affect or emotion).
- Depression (deterioration of mood and loss of ability to feel joy).
In the reviews of "Baclofen" there is information about the harmful reaction of the body to the effects of the drug from the heart and blood vessels. Similar phenomena act as the following diseases:
- Arterial hypertension (increased blood pressure).
- Cardiopalmus.
- Chest pain.
- Cardiac collapse (the condition is manifested by the occurrence of a sharp weakness and pallor in a person).
The stomach and intestines also actively respond to the use of the drug, with improper dosage, for example:
- Diarrhea.
- Vomiting.
- Dyspepsia (a violation of the normal functioning of the stomach, which is characterized by difficult and painful digestion of food).
- Pain in the abdomen.
If the instructions for use for "Baclofen" and the use of the medication without a doctor's prescription are not followed, negative effects from the genitourinary system of the body can:
- Urinary incontinence.
- Spontaneous bowel movements.
- Sexual dysfunction
- Erectile dysfunction.
On the part of the respiratory system, perhaps the manifestations of the following disorders:
- Difficulty breathing.
- Suffocation.
In addition to these harmful reactions, other negative phenomena may develop:
- Muscle pain.
- Rashes on the surface of the skin.
- Irritation.
- Swelling of the extremities.
- Sweating.
- Weight gain.
If treatment is accompanied by symptoms such as chest pain, depression, vomiting, heavy breathing, you should immediately consult a doctor or call an ambulance.
Overdose
If you violate the instructions for use of the drug "Baclofen", poisoning may occur, in which it is necessary to conduct complex therapy.
Contraindications
The following diseases are considered a ban on the use of "Baclofen":
- Sensitivity to the active substance of the drug.
- Stomach ulcer.
According to reviews of Baclofen, tablets are prescribed during pregnancy only in exceptional situations, when the therapeutic effect of using the drug is higher than the likely risk to the unborn child. Lactation and taking the drug is not recommended to combine.
Analogues of the drug
According to the instructions for use, analogues of "Baclofen" has, like any other drug, for example:
- Betaferon.
- Sinacten.
- "Fampira".
- Novantron.
- Polynorm.
- Avonex
- "Infibet".
- "Alcheba".
- Abaggio
- Myocaine.
- "Mephedol".
- "Sibazon".
Sibazon
The drug is a tranquilizer of sedative, anticonvulsant, muscle relaxant and hypnotic effects. "Sibazon" has moderate inhibitory activity, can provoke the expansion of coronary vessels and a decrease in blood pressure, increases the threshold of pain sensitivity.
The drug is produced in the following forms:
- Capsules are biconvex, milky. Tablets are packaged in contour cells of ten pieces.
- Solution for intravenous or intramuscular administration. The liquid is clear or with a yellowish tint. The solution is available in ampoules of two milliliters, a total of five ampoules in the contour cell.
Sinacten
The medication has an anti-inflammatory, anti-allergic effect, which affects fat, mineral and protein metabolism.
"Sinacten" is available in the form of a suspension for intramuscular administration. In one package, there can be from one to ten ampoules of one milliliter each. According to the instructions for use, the drug is an analogue of "Baclofen."
After applying the drug in a dosage of one milligram, the content of the active substance (cortisol) increases, its maximum marks are fixed for twelve hours after administration. For twenty-four hours, the increased content of the active component persists, then after about forty-eight hours the mark returns to normal. The prolonged effect of the drug is due to the slow release of tetracosactide.
Slow elimination of the active substance is ensured by the absorption of tetracosactide on zinc phosphate.
"Sinacten" is administered only strictly intramuscularly. At the beginning of treatment, the medication is used every day. After about three days, they go into maintenance mode. The cost of the drug varies from 2000 to 2500 rubles.