This article will be presented to the drug "Flagil" instructions for use, price and reviews. The medication acts as a means that has an antiprotozoal effect. It also has an antibacterial effect and is intended for local use in the field of gynecological practice. The composition of this medicine includes an active substance called metronidazole.
The mechanism of action of Flagil lies in its ability to provoke biochemical recovery of the fifth nitro group of metronidazole via intracellular transport proteins of simple and anaerobic microorganisms. As a result of this process, the amino acid synthesis is inhibited by the cells of the microorganism or protozoa, as a result, their death occurs. Consider this drug in more detail and find out how effective it is.
What does the instruction to “Flagil” tell us?
Description of the drug
It has a wide range of antiprotozoal and antibacterial effects. The presented drug is highly active against many anaerobic microorganisms and sensitive strains. This is confirmed by the instructions for use to the "Flagil".
As a rule, twenty percent of the drug taken into the systemic circulation. A plasma concentration of the drug is twelve percent of a single dose. The elimination half-life usually lasts up to twelve hours. The drug binds to plasma proteins in an amount of about twenty percent.
Indications
According to the instructions, “Flagil” is prescribed in the following cases:
- Conducting local treatment of trichomonas, and in addition, non-specific vaginitis.
- Prevention of the development of anaerobic infection in cases of surgical intervention in the region of the abdominal cavity or pelvis.
Contraindications
The instructions to the "Flagil" are the following contraindications regarding its use:
- The presence of hypersensitivity to imidazoles.
- The development of organic damage to the nervous system, including the presence of epilepsy.
- The development of various blood diseases, including a history of.
- Lack of coordination of movements.
- Pregnancy and the lactation period.
- The presence of liver failure.
Now we find out how to use the presented tool and in what quantity.
Method of using the drug
"Flagil" is intended for intravaginal use. The presented medicine is released in the form of suppositories. This drug is used exclusively for adults. Dosage in the presence of Trichomonas vaginitis is one suppository per day. The total duration of treatment with this medicine is ten days. It is necessary to combine “Flagil” with oral use of metronidazole.
Dosage in the presence of nonspecific vaginitis is one suppository twice a day. The total duration of the course is one week. If necessary, you can connect metronidazole orally. Mandatory treatment of the sexual partner is also required, regardless of whether he has symptoms or not. Treatment with a medication and its analogues should not last more than ten days, and courses should not be repeated more than three times a year.
This is reported to us by the instructions for use. The price of the “Flag” will be given at the end of the article.
Side effect of the drug
Against the background of taking the drug, the following side effects are recorded:
- On the part of the digestive system, patients may experience a metallic taste in the mouth along with nausea, dryness, glossitis, decreased appetite, stomatitis, anorexia, pancreatitis, diarrhea, vomiting and pain in the epigastric region.
- The nervous system may respond with dizziness, headaches, impaired coordination of movements, irritability, confusion and increased excitability. The appearance of depression, convulsions, insomnia, peripheral neuropathy and hallucinations is not ruled out.
- Allergic reactions are usually manifested by flushing of the skin, urticaria, fever, allergic rhinitis, and so on.
- A malfunction of the urinary system may be accompanied by cystitis, polyuria, dysuria, candidiasis, urinary incontinence and its staining in a brownish color.
- Local reactions can manifest themselves in a burning sensation in the genital area. In addition, vulvitis may occur.
Among other things, the development of neutropenia and leukopenia is not ruled out. Side effects are often the main reason for negative reviews about the drug that people leave on the Internet. To prevent them, it is necessary to use the drug “Flagil” only after receiving medical advice, and in addition, a detailed study of the instructions for the presented medicinal product.
Instructions for use with Flagil candles also contain special instructions.
Special instructions for the use of the drug
When taking the drug, the use of alcoholic beverages is strictly contraindicated, since the development of side effects such as the appearance of vomiting, fever, or tachycardia is likely. If you need long-term use of the means "Flagil" it is extremely important to control the hematological indicator. In the case of leukopenia, the question of the subsequent use of this drug depends on the risk of infection.
During the treatment of trichomonas vaginitis, it is important to refrain from sexual intercourse. During menstruation, Flagil therapy should not be discontinued. In case of neurological symptoms, the treatment with the presented medicinal product must be stopped. The metronidazole that is part of the drug has the ability to immobilize treponema, and this in turn can lead to a false positive Nelson reaction.
The “Flagil” instruction also contains this information.
Interaction with other medical devices
The product may cause ethanol intolerance. The simultaneous use of this drug with Disulfiram can cause neurological symptoms. The presented preparation can enhance the effect of indirect anticoagulants, increasing the plasma concentration of lithium, and, in addition, cyclosporine and bisulfan. The simultaneous use of Phenobarbital with Phenytoin may accelerate the elimination of Flagil. The combination of “Flagil” with non-depolarizing muscle relaxants is also not recommended.
"Flagil" and its analogues
The drug “Flagil” has many different analogues, among which are such drugs as “Bacimex”, “Klion”, “Metroksan”, “Metrolaker”, “Orvagin”, “Rosamet”, “Trichopol”, “Efloran” and others.
True, information on analogues does not contain instructions for use.
Reviews about "Flagila"
The presented drug has a high antitrichomonas, and, in addition, antibacterial effectiveness, which has been repeatedly proven in a number of clinical studies. That is why most of the reviews of the drug "Flagil" by gynecologists are mostly positive. Subject to the recommendations, along with the dosage regimen, this drug is well tolerated.
As for patients who happened to use the presented drug for their treatment, in general, they report that the tool helped and was effective. However, such shortcomings as the development of some side effects are noted, among which, as an example, the occurrence of headaches and a feeling of an unpleasant aftertaste in the mouth are most often cited.
According to many women, side effects do occur, but most often they are quite tolerable, and treatment with this drug directly helps to achieve the desired effect. Thus, in general, both patients and doctors recommend the use of this drug if necessary.
It is important that everyone can, if necessary, read the instructions for the “Flagil”.
Price
How much is this medicine? This drug can be purchased at a pharmacy for about 120-150 rubles. It depends on the region and the pharmacy network.