Dosage form of the drug "Concor": The instruction says that the drug is supplied in tablets that are film-coated. Biconvex tablets are light yellow and have a heart shape. There are dividing risks on each surface. There are two types of tablets, varying in concentration.
Structure:
Active substance:
- Bisoprolol hemifumarate - 5/10 mg (in 1 table, respectively)
Excipients:
- Anhydrous Calcium Hydrophosphate
- Anhydrous Colloidal Silica
- Magnesium stearate
- Microcrystalline cellulose
- Crospovidone
- Corn starch
pharmachologic effect
The medicine belongs to the group of beta 1 adrenergic blockers, which do not have their sympathomimetic activity. The drug also does not have a membrane stabilizing effect.
Concorre decreases renin activity, reduces myocardial oxygen demand, and reduces heart rate. It also has antiarrhythmic, antianginal and hypotensive effects. With an increase in the dose consumed, the drug may act as a beta 2 blocker.
On the first day of taking the drug, OPSS increases, and after a few days it returns to normal. With prolonged use of the drug, OPSS may decrease.
The antiarrhythmic effect of the drug is associated with its ability to reduce myocardial oxygen demand, reduce the effect of the renin-angiotensin system, and stimulate sympathetically peripheral vessels.
Concor Indications
- Ischemic heart disease
- Arterial hypertension
- Chronic heart failure
Side effects of concor
The instruction describes almost all the symptoms that can be caused, as a result of side effects of the drug.
Side effects associated with the gastrointestinal tract:
- Vomiting
- Nausea
- Constipation
- Diarrhea
- Dry mouth
- Hepatitis
Side Effects Associated with CCC:
- Bradycardia
- Arterial hypertension
- Angiospasm
- Arterial hypotension
- Angiospasm
- Violation of AV conduction
- Arterial hypertension
- Decompensation of heart failure
Side effects associated with the central nervous system:
- Asthenia
- Dizziness
- Headache
- Depression
- Sleep disturbance
- Fatigue
- Nightmares
- Cramps
- Hallucinations
Side effects associated with the organs of vision:
- Tear reduction
- Conjunctivitis
- Visual impairment
Side Effects Associated with reproductive system:
Possible allergic reactions to the drug:
- Rash
- Itchy skin
- Skin redness
Side effects that may be associated with dermatological causes:
- Alopecia
- Sweating
- Psoriasis
During the course of taking the drug, you can not drastically change the dose of the medicine and break off the treatment, because this can give a complication to the heart, especially for patients with coronary artery disease.
Contraindications "Concor"
The instruction includes a list of diseases in which taking the drug is not recommended.
- AV block 2 and 3 degrees
- Collapse
- Cardiogenic shock
- Severe bradycardia
- Heart failure
- Sinoarterial block
- MAO inhibitors (except type B)
- Marked decrease in blood pressure
- COPD and severe bronchial asthma
- Raynaud's disease
- Metabolic acidosis
- Pheochromocytoma
- Under 18 years old
- Sensitivity to components
In addition, this drug must be used very carefully if the patient has a history of liver failure, thyrotoxicosis, diabetes mellitus, myasthenia gravis, renal failure, Prinzmetal angina, psoriasis, and depression.
Overdose with Concor
The instruction says that if an overdose occurs, it is necessary to rinse the stomach, take absorbent drugs and prescribe symptomatic therapy to the victim.
Medicinal interaction of the drug "Concor" core
The instruction does not contain descriptions of the consequences of the interaction of concor with other drugs. Concor quite often can mutually affect the effectiveness of drugs used simultaneously with it.