Nonsteroidal anti-inflammatory drugs are used not only in the presence of joint and muscle diseases, but also in other pathological conditions. Such drugs are designed to reduce pain and reduce the inflammatory process. Often they are used in ophthalmic practice after surgery.
One of the most popular remedies in this area is Broxinac - eye drops. Instructions, analogues, indications, side effects and contraindications of this drug will be presented below.
Release form, description, composition and packaging of the drug
Medication "Broxinac" (eye drops), the instruction of which is contained in a box of thick paper, is a clear solution of greenish-yellow color. Its active ingredient is bromfenac sodium sesquihydrate.
It should also be noted that the composition of the drops also includes auxiliary components, which are presented in the form of boric acid, benzalkonium chloride, disodium edetate dihydrate, povidone K-30, polysorbate 80, sodium borate decahydrate, sodium hydroxide, sodium sulfite anhydrous and purified water.
In what packaging can I buy Broxinac? Eye drops go on sale in bottles placed in cardboard boxes.
Pharmacological properties
What is a broxinac solution (eye drops)? The instruction (reviews on the effectiveness of the medication are presented a bit below) indicates that this is a non-steroidal anti-inflammatory drug that has an analgesic and anti-inflammatory effect.
By inhibiting cyclooxygenase 2 and 1, said preparation is capable of blocking the synthesis of prostaglandins from arachidonic acid. As a result of this effect, inflammation decreases and pain syndrome decreases.
Studies by specialists have shown that prostaglandins are mediators of certain types of inflammation in the visual organs. During experiments on animals, it was found that these substances contribute to the violation of the blood-brain barrier, as well as increase vascular permeability, causing leukocytosis and vasodilation. Moreover, prostaglandins significantly increase intraocular pressure.
Kinetic features
Is Broxinac (eye drops) absorbed? The instruction reports that the concentration of this drug in the blood is much lower than the measurement limit. In this regard, it has no clinical significance.
According to experienced specialists, bromfenac penetrates well into the cornea. With a single use of the drug, its concentration in the aqueous humor of the visual organs is 79 ± 68 ng / ml. These values are observed after 155-180 minutes after instillation of the solution into the eyes. In this case, the indicated concentration remains for 13-23 hours.
The half-life of bromphenac from aqueous humor is approximately 1.4 hours.
Indications for the use of drops
Are you aware of the purpose of using Broxinac? Eye drops are used to treat postoperative inflammation and to reduce pain in people after cataract extraction.
Contraindications
What conditions of the patient are forbidden to use the medication "Broxinac" (eye drops)? Instructions for use (on prescription, this tool can be purchased at almost any pharmacy in Moscow) informs about the following contraindications:
- the presence of increased sensitivity to the substances of the solution, as well as to other NSAIDs;
- urticaria, asthma attacks and symptoms of acute rhinitis, which are worse when taking NSAIDs or acetylsalicylic acid;
- minor age (the efficacy and safety of using the medication in children and adolescents have not been investigated).
Sodium sulfite contained in the solution in susceptible people can cause an allergic reaction, including asthma attacks and anaphylactic shock. Therefore, this category of people, the drug is prescribed with extreme caution. It should also be noted that sensitivity to sulfites is increased in patients with a history of allergy and bronchial asthma.
One cannot fail to say that when using the drug in question, there is a likelihood of developing cross-sensitivity to phenylacetyl acid derivatives, acetylsalicylic acid and other NSAIDs. In this regard, special care must be taken in the treatment of people who have previously manifested negative reactions to these drugs.
What other contraindications should you know before using Broxinac solution (eye drops)? Instructions for use states that NSAIDs as a result of platelet aggregation disorders can significantly increase bleeding time.
The use of local anesthetics in combination with ophthalmic surgery helps to increase bleeding of tissues of the visual organs (including the anterior chamber of the eye).
In connection with all of the above, we can safely conclude that the medication in question should be used with extreme caution in people who have a history of bleeding, as well as if the patient is taking other drugs that increase the coagulation time blood.
As medical practice shows, the use of local NSAIDs in patients with corneal denervation, complications after eye surgery, corneal epithelial defects, rheumatoid arthritis, diabetes mellitus, superficial diseases of the visual organs, or repeated surgical interventions that were carried out over a short period of time can significantly increase the risk of developing unwanted effects from the cornea.
The drug "Broxinac" (eye drops): instruction
How and in what dosage do they install the drug in the conjunctival sac? According to the instructions, this medication is used one drop once a day.
As a rule, therapy with this agent is started one day before surgery and continued during the first two weeks of the postoperative period (including on the day of surgery).
What to do if a patient has missed the Broxinac instillation procedure? Eye drops, reviews of which are ambiguous, should be used as soon as possible in the dose prescribed by the instructions.
In the event that it has already been 20-24 hours, the drug should be instilled at the next appointed time. It is forbidden to double the dose in order to compensate for the missed one.
The method of application and dosage of the solution for treating patients over 65 years of age do not differ from the method of application and dosage in younger people.
Adverse reactions
What side effects occur while using Broxinac? Eye drops, the instruction of which was presented above, with a single application can cause the following reactions:
- corneal erosion, thinning and perforation of the cornea, destruction of the epithelium;
- severe and frequent headaches;
- unusual sensations and discomfort in the eyes, burning and itching, irritation, redness and pain, inflammation of the iris, conjunctival hyperemia;
- decreased visual acuity, corneal edema, retinal hemorrhage, bleeding from the vessels of the eyelids, photophobia, exudates on the fundus;
- nosebleeds, nasal discharge, cough, asthma;
- corneal ulcer;
- swelling of the face.
Overdose Signs
What should I do if a patient accidentally takes the Broxinac drug inside? Eye drops, photos of which you can find in this article, are for local use only. When using the medication inside, you should immediately drink a large amount of water. This is necessary in order to reduce the concentration of the drug in the stomach.
Compatibility with other medicines
The drug is allowed to be used simultaneously with other ophthalmic agents, including alpha-adrenergic agonists, beta-blockers, mydriatics and carbonic anhydrase inhibitors. In this case, all of the listed medicines should be used with an interval of 5 minutes.
Pregnancy and lactation
Can Broxinac be used during pregnancy? Eye drops, the synonyms of which are indicated below, can be used during gestation, but only if the intended effect for the expectant mother exceeds the probable risk for the baby.
It should also be noted that drops should be avoided in late pregnancy.
With extreme caution, this medication is recommended for women during breastfeeding.
Special recommendations
The use of local NSAIDs a day before surgery on the eyes and within two weeks after an ophthalmic intervention can increase the risk of developing and the severity of adverse reactions from the cornea.
Instillation of non-steroidal drops contributes to the occurrence of keratitis.
In susceptible people, prolonged use of local NSAIDs can cause epithelial rupture, as well as thinning, erosion, perforation of the cornea and the formation of ulcers on it. Such side effects pose a risk of vision loss.
People with symptoms of rupture of the corneal epithelium should immediately stop using the solution and consult an experienced ophthalmologist.
The use of NSAIDs can inhibit healing processes, especially when combined with local corticosteroids. Patients should be informed about this feature of the medication.
When using the Broxinac solution it is forbidden to wear contact lenses.
Patients should be warned that they do not touch the tip of the dropper bottle with their fingers, and also do not touch any other surface, including the mucous membrane of the eye. Otherwise, this can lead to contamination of the drug.
The medication in question only slightly affects the person’s ability to drive vehicles and drive dangerous machinery. After instillation of the solution, the patient may have blurred vision for a short time. In this regard, it is recommended to wait a bit until it is fully restored.
The drug "Broxinac" (eye drops): analogues and cost
There are no synonyms for this tool. However, if necessary, it can be replaced by such analogues as Diclofenac, Ketadrop, Voltaren Ofta, Uniklofen, Diklo-F, Diklofenaklong, Nevanak, Akyular, Indokollir.
As for the cost, the average price of eye drops considered by us is 370-420 rubles.
Consumer Reviews
Most people leave only positive reviews about this drug. According to them, Broxinac drops effectively cope with the task. As a rule, they are prescribed after surgery in front of the eyes. Reviews say that the use of the drug helps to reduce the inflammatory process and reduce pain.
However, often against the background of the use of the mentioned eye drops in patients, adverse reactions are observed, including those hazardous to vision. In this case, the medication must be canceled independently and immediately consult an ophthalmologist.
It should also be noted that this drug has other disadvantages. Patients attribute high cost to them. In addition, people constantly complain that it is quite difficult to find such a tool in small cities of Russia. Often it has to be ordered through the Internet.