The drug "Sibutramine", the price of which is from 584 p., Refers to the drugs used to treat obesity. The medication has a central effect. The mechanism of drug activity is based on the ability to selectively inhibit the reuptake of norepinephrine, serotonin, and (to a lesser extent) dopamine. Sibutramine hydrochloride helps accelerate and prolong the feeling of fullness. This, in turn, provokes a decrease in food requirements.
After penetration, a high absorption is noted. The drug is metabolized almost completely in the liver cells. The maximum concentration of the drug is observed after an hour.
Indications
The medicine "Sibutramine" (doctors testify to this) is effective as maintenance therapy as part of a comprehensive treatment for alimentary obesity with a mass index of 30 kg / sq m or more, from 27 kg / sq m or more, accompanied by other risk factors associated with overweight. Risk factors, in particular, include an insulin-dependent type of diabetes mellitus, hyperlipidemia.
Dosage regimen
It is recommended to start taking a dose of 10 mg / day. In case of insufficient effectiveness of the indicated amount of the drug “Sibutramine” (doctors' reviews indicate this), it is advisable to increase the dosage to fifteen milligrams per day. In the absence of a therapeutic result when taking the medication in this dose, the drug is canceled. The duration of use of the drug is no more than a year, due to insufficient information on safety during long-term treatment.
Adverse reactions
The drug "Sibutramine" (reviews of doctors warn about this) can provoke a dry mouth, a change in appetite, constipation, paresthesia, and a feeling of anxiety. During treatment, patients experience dizziness, a feeling of palpitations, tachycardia, and seizures.
In some cases, there is an increase in the activity of enzymes in the liver, exacerbation of hemorrhoids, vasodilation, severe hypertension, and increased heart rate. The drug can provoke thrombocytopenia, acute
interstitial nephritis . As a rule, the negative consequences of taking the Sibutramin medication (expert reviews confirm this) develop in the initial stages of therapy (in the first month of treatment). With continued treatment, their frequency and intensity usually decrease.
Contraindications
It is not recommended for organic obesity, bulimia nervosa or anorexia and other serious eating disorders, ischemic heart disease, mental pathologies, and decompensated chronic heart failure. Contraindications include lactation, heart defects (congenital type), arrhythmias, pregnancy, hepatic impairment of severe course, benign prostatic hyperplasia. The drug is not recommended for drug or alcohol dependence, uncontrolled arterial hypertension, hyperthyroidism.