The drug "Derinat" is an immunomodulatory drug. It helps to greatly enhance the human immune system. In our article, we will examine in detail the instructions for use with Derinat, and also learn how patients respond to it.
The composition and form of release funds
The drug is produced in the following pharmaceutical forms:
- Solution for injection 1.5% (ampoules with a volume of 5 ml).
- Solution for external and local use 0.25% in vials or dropper bottles with a volume of 10 ml.
- Drops "Derinat" for the eyes of 0.25%.
The composition of a milliliter of a solution for intramuscular injections includes:
- The active component is sodium deoxyribonucleate in an amount of 15 ml.
- Auxiliary components in the form of sodium chloride and water for injection.
The composition of a milliliter of a solution intended for local and external use includes:
- The active component is sodium deoxyribonucleate in an amount of 2.5 ml.
- Auxiliary components in the form of sodium chloride and water for injection.
Pharmacodynamics of the drug
According to the instructions for use, Derinat activates the process of humoral, and, in addition, cellular immunity. An immunomodulatory effect is provided by stimulation of B-lymphocytes, as well as by activation of T-helpers. The drug can activate the nonspecific resistance of the body, optimizing the inflammatory response along with the immune response to antigens that have a viral, fungal and bacterial nature. The medicine causes stimulation of the regenerative and reparative process, increasing the body's resistance to the action of infection. In addition, Derinat can regulate hematopoiesis, providing normalization of lymphocyte levels along with leukocytes, granulocytes, platelets and phagocytes.
Due to the pronounced nature of lymphotropy, the use of Derinat stimulates the drainage and detoxification properties of the lymphatic system. This medication significantly reduces the sensitivity of cells to the effects of radiation treatment and chemotherapeutic drugs. Derinat does not cause a teratogenic, embryotoxic or carcinogenic effect.
Pharmacokinetics of the drug
Quickly absorbed, Derinat is distributed in the organs along the endolymphatic channels. The medicine has a high tropism in relation to the blood forming organs. The drug is embedded in the cellular structure, due to which it takes an active part in metabolism. In the framework of an intensive entry into the circulatory system, in parallel with the process of metabolism and excretion, the medication is redistributed between plasma and shaped blood elements. Against the background of intramuscular injections, the half-life of the drug is about 72 hours. This confirms the instructions for use to Derinat.
The medicine is distributed fairly quickly in the body. During the daily course of therapy, it accumulates in the tissues, and, in addition, in the organs, mainly in the lymph nodes, as well as in the spleen and bone marrow. To a small extent, the agent accumulates in the brain, stomach, liver, and also in the large intestine. The maximum concentration in the bone marrow is approximately 5 hours. Directly in the brain for half an hour. The medicine can penetrate the blood-brain barrier, then it is metabolized and excreted in the form of metabolites. To a lesser extent, the drug is excreted in feces.
Next, we will consider in detail in which cases doctors prescribe this drug to their patients.
Indications for use
According to the instructions for use, Derinat in the form of a solution for intramuscular injection is used as part of the treatment of the following diseases and conditions:
- Observation of hematopoiesis disorders.
- The development of radiation damage to the body.
- The presence of resistance and myelodepression in relation to cytostatics among cancer patients, which is associated with radiation or cytostatic treatment. In this case, stabilization of hematopoiesis is required along with a decrease in the cardiotoxicity of chemotherapy drugs.
- The presence of stomatitis induced by cytostatic drugs.
- The appearance of erosive gastroduodenitis along with peptic ulcer of the stomach and intestines
- The presence of obliterating diseases of the vessels of the limbs, which are in the second or third stage.
- The development of coronary heart disease.
- The appearance of purulent-septic complications, and, in addition, odontogenic sepsis.
- The presence of non-healing wounds, trophic ulcers.
- The presence of pulmonary tuberculosis along with inflammatory diseases of the respiratory tract.
- The appearance of a burn disease.
- The development of rheumatoid arthritis.
- The presence of endometritis, endometriosis, salpingo-oophoritis or fibroids.
- The appearance of ureaplasmosis, chlamydia or mycoplasmosis in patients.
- The appearance of chronic obstructive pulmonary pathology.
- The presence of benign prostatic hyperplasia along with prostatitis.
- Against the background of the postoperative period. This tool is often used in surgical practice.
The use of drugs for monotherapy
As part of monotherapy, the drug in the form of solutions for local and external use is used in the development of the following diseases:
- The presence of dystrophic and inflammatory eye diseases.
- The appearance of inflammatory processes in the oral mucosa.
- The presence of acute respiratory viral infections. This drug is used not only for therapy, but also for the prevention of such diseases.
- The appearance of acute respiratory infections.
Complex treatment
As part of a comprehensive treatment, the drug is prescribed for the treatment of the following diseases:
- The development of chronic and acute ailments of the upper respiratory tract, for example, with rhinitis and sinusitis, including sinusitis and frontal sinusitis.
- The appearance of fungal, chronic inflammatory diseases along with bacterial and other infections of the mucous membranes as part of gynecological practice.
- The presence of infected and prolonged non-healing wounds, including diabetes mellitus.
- The appearance of obliterating ailments of the lower extremities.
- The occurrence of gangrene and trophic ulcers.
- The presence of post-radiation skin necrosis.
- The presence of frostbite or burns.
Instructions for use and reviews of Derinat for children will be discussed below.
Contraindications
Use the product should not only be in cases of hypersensitivity to certain components of the drug. Next, we consider the instructions for the use of the drug presented and find out in what dosages it is prescribed to patients with various diseases.
Instructions for the use of injections "Derinata"
For adult patients, the drug is prescribed in the form of a solution for intramuscular injections. Intervals of administration are three days. Depending on certain indications, the following treatment regimens are used:
- With coronary heart disease, 5 ml of the solution is administered, the interval between the administration procedures is three days. The treatment course involves the introduction of 10 injections.
- In case of cancer, 5 ml of the solution is administered, the interval between the administration procedures is two days. The treatment course involves the introduction of 10 injections.
- In case of peptic ulcer of the stomach and intestines, 5 ml of the solution is also administered, the interval between the administration procedures is two days. The treatment course involves the introduction of 10 injections. Instructions for use for injections "Derinat" confirms this.
- With tuberculosis, patients are injected with 5 ml of the solution, the interval between administration procedures is one day. The treatment course involves the introduction of 15 injections.
- In the presence of benign prostatic hyperplasia, 5 ml of the solution is administered, the interval between the administration procedures is two days. The treatment course involves the introduction of 10 injections.
- With chlamydia, endometriosis, endometritis, mycoplasmosis, ureaplasmosis, myoma and salpingo-oophoritis, 5 ml of solution is administered, and the interval between administration procedures is two days. The treatment course involves the introduction of 10 injections.
- In the presence of chronic inflammatory ailments, 5 ml of the solution is administered to patients. The first five injections are done with an interval of 24 hours each, and the subsequent ones in compliance with a three-day interval. The treatment course involves the introduction of 10 injections.
- In the presence of acute inflammatory ailments, 5 ml of the solution is administered to patients, the interval between the administration procedures is three days. The treatment course involves the introduction of 5 injections. This is indicated in the instructions for use with Derinat ampoules.
Instructions for use of the drug "Derinat" for children
The multiplicity of intramuscular injections of the drug in children is exactly the same as in adult patients. Thus, the drug is used in the following doses:
- Until the age of two, the average single dose is 7.5 milligrams.
- From two to ten years, a single dose is determined at the rate of 0.5 milligrams of the drug per year of life.
- Children who are older than 10 years old are prescribed an average single dose, which is equal to 75 milligrams. The course dose involves the introduction of 5 injections of the drug.
Drops "Derinat"
Consider the instructions for use with Derinat drops for children and adults.
The drug in the form of solutions for external and local use is used depending on the location of the ongoing processes. The drug can be used by adults and children from the first days of life. For prevention of otolaryngological diseases, nose drops “Derinat” are used.
Instructions for use indicate that as part of this procedure, two drops of the solution are used in each nasal passage up to four times a day. The duration of therapy is usually two weeks.
Against the background of the development of symptoms of a respiratory pathology, during the first day you need to drip the medicine into the nose three drops in each stroke. This is done every half hour, and then four times a day, two drops. The duration of the therapeutic course can last from 5 to 30 days. This is also confirmed by the instructions for use to the nose drops "Derinat".
Depending on a particular disease, the drug in drops is used according to certain schemes.
- As indicated by the instruction for use in Derinat nasal drops for inflammatory pathologies of the sinuses and nasal cavity, the drug is prescribed six times a day, three drops per stroke. The course lasts two weeks.
- With inflammatory diseases of the oral cavity, the drug is taken six times a day. In this case, rinse the oral cavity. One bottle of medicine is enough for three rinses. The duration of the treatment course is 10 days.
- In chronic inflammatory ailments, as well as fungal, and other infections in the gynecological sphere, the vagina is irrigated, and, in addition, the cervix. For this, intravaginal tampons with a solution are provided. For one procedure, 5 ml of the drug is required, the frequency of use is twice a day. Course duration: two weeks.
- In the presence of severe inflammatory and dystrophic processes in patients in ophthalmic practice, the Derinat preparation is used twice a day. They need to bury their eyes in two drops each. The duration of the treatment course is 45 days. So described in the instructions for use. Reviews about the Derinat drops are abundant.
- With hemorrhoids, a rectal administration of the drug is prescribed using microclysters of 40 ml. The duration of the treatment course is 10 days.
- With post-radiation necrosis of the mucous membranes and integuments of the skin, long non-healing wounds, and, in addition, burns, frostbite, gangrene and trophic ulcers of various etiologies, the drug is prescribed three times a day. At the same time, an application dressing with the applied solution is required to be applied to the affected areas. In addition, the affected surface can be treated up to five times a day with a preparation from a spray of 40 ml. The duration of the therapeutic course: three months.
- In the presence of obliterating ailments of the lower extremities in order to achieve a systemic effect, this medicine is instilled six times a day, this is done in each nasal passage two drops. Duration of the treatment course: up to six months.
Derinat (spray)
Consider also a brief instruction for use with Derinat spray. Use the drug according to the following algorithm:
- Remove the protective cap from the nozzle of the bottle.
- Bring the bottle to your mouth so that the nozzle faces the throat.
- Hold the breath.
- Press the nozzle several times.
- Turn the bottle between presses so that the medication is sprayed evenly across the throat. According to the instructions for use, Derinat spray can also be sprayed into the nose. The effectiveness of the drug is maintained.
As indicated by the instructions for use, for children, the Derinat spray is used without age restrictions.
However, the aerosol form is not very convenient for babies. Spraying involves holding your breath, which is difficult for young children to do. For children, Derinat drops are more suitable. You can drip the product on the cheek or on the nipple.
Dosage for children is reduced in accordance with age:
- 2 years or less - 1 spray;
- from 2 to 10 years - 2 sprayings;
- 10 years and older — at an adult dosage.
Side effects with the use of the drug
Against the background of the intravenous administration of Derinat in patients with diabetes mellitus, it is likely that a hypoglycemic effect is observed, which must be taken into account when controlling the amount of glucose in the blood. In the framework of local and external use of the drug, no side effects have been identified. Negative manifestations due to overdose were also not detected.
Instructions for use with Derinat nasal drops and injections confirm this.
Special instructions for use
It should be noted that Derinat does not possess embryotoxic, and, in addition, carcinogenic or teratogenic effects. Subcutaneous administration of the drug is possible. Against the background of surgical sepsis, the use of the drug as part of a comprehensive treatment leads to the activation of the immune system along with a decrease in the level of intoxication. This medication leads to the normalization of blood formation. In addition, there may be an improvement in the work of the organs that are responsible for the detoxification process of the internal environment. Thus, the activity of the spleen and lymph nodes improves.
The drug can reduce the iatrogenicity of drugs in the treatment of rheumatoid arthritis with 50% achievement of improved complex values of pathology activity. Derinat potentiates the therapeutic effect of basic treatment for peptic ulcer of the stomach and intestines.
According to studies, the effectiveness of this drug was proved against the background of standard treatment in patients with exacerbation of chronic lung disease of varying degrees of complexity. In this case, an intramuscular solution is used, and the interval between administrations is two days. The treatment course involves the introduction of 10 injections. In the framework of external and local use in the treatment of gangrenous processes under the influence of Derinat, spontaneous rejection of a number of necrotic masses with subsequent restoration of the skin is noted in some foci. In the presence of burns and open wounds, doctors note the analgesic effect of the drug.
Instructions for use with Derinat for children and adults are very detailed, features are indicated for pregnant women.
Pregnancy and use of the drug
Derinat in the form of solutions for external and local use during pregnancy can be used without any restrictions. The drug in the form of solutions for intramuscular administration is used only after passing a consultation with a doctor. The decision to prescribe this medicine to pregnant women is made on the basis of assessing the ratio of the intended benefit to the woman and the risk to the fetus.
The drug Derinat in the form of solutions for intramuscular administration during lactation is recommended to be used only after visiting the attending physician. It should also be noted that this drug is allowed to be used to treat children from the very first day of life.
Interaction with other medicines
The drug Derinat can increase the effectiveness of cytostatics, and, in addition, antitumor antibiotics from the anthracycline group. The use of Derinat as a part of complex treatment makes it possible to increase the effectiveness, reducing the duration of therapy against the background of a significant reduction in the dose of antibiotic medicines and antiviral drugs. As for local use, such a drug is incompatible with hydrogen peroxide, and, in addition, with ointments based on fat. This describes the instructions for use.
Analogues of Derinat
The analogues of this drug are pharmaceuticals in the form of "Deoxinate" and "Panagen". They can be purchased at any pharmacy.
Storage conditions of the drug and its cost
Keep the medicine presented in a dark place, which should also be dry and out of the reach of children. This medication can be stored at a temperature of 4 to 20 degrees. Shelf life is five years. , , 2 . «».
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As for the negative reviews about Derinat, they contain information that is related to the fact that the injections that must be performed during the treatment period are extremely painful. It is also noted that the effect of the treatment is short-lived. Many are not satisfied with its cost, which reaches two thousand rubles. But, nevertheless, the drug Derinat today is a fairly popular and often prescribed immunostimulating agent.
We reviewed the instructions for use with Derinat drops, spray and injections.