The drug is available in the form of enteric-coated tablets, as well as in the form of a solution for injection.
The tablets are whitish, oval.
Structure:
Active substance:
- Ademethionine - 400 mg (in 1 tablet)
Excipients:
- Anhydrous Colloidal Silica
- Sodium Starch Glycolate
- Magnesium stearate
- Microcrystalline cellulose
The composition of the enteric coating:
- Polyethylene glycol
- Simethicone
- Polymethacrylate
- Polysorbate
- Talc
- Purified water
The solution for injection is white.
Structure:
Active substance:
- Ademethionine - 400 mg (in 1 bottle)
Excipients:
- Sodium hydroxide
- Water for injections
- L-lysine
Pharmacological action of the drug
The drug "Heptral" refers to hepatoprotectors, also having an antidepressant effect. In addition, ademetionine (active substance) can have cholekinetic and choleretic effects. The drug is involved in the processes of transmethylation, while donating the methyl group of phospholipids of proteins, cell membranes, neurotransmitters and hormones, then trans sulfation - the precursor of taurine, glutathione and cysteine. Ademethionine can increase the amount of glutamine in the liver, and taurine and cysteine in the blood plasma, reduce the amount of methionine in the serum, thereby normalizing the metabolic reaction in the liver.
The drug has a choleretic effect, which is due to an increase in the polarization and mobility of the liver cell membranes, due to the stimulation of the conversion of phosphatidylcholine into them. Due to this, the function of transport systems associated with the membranes of hepatocytes of bile acids is significantly improved and promotes the withdrawal of bile acids.
Hepatoprotective and choleretic effects of the drug can last up to three months.
Pharmacokinetics
Thanks to a special enteric-soluble membrane, the tablets reach the duodenum and dissolve there. After a single dose, the maximum concentration of heptral in the blood is reached somewhere after a few hours.
When administered orally, the bioavailability is 5%, with intramuscular administration - 95%. The drug may slightly bind to serum proteins. The medicine can penetrate the BBB; its presence is always noted, regardless of the route of administration, in the cerebrospinal fluid.
Indications for the use of the drug "Heptral"
The instruction contains basic information on the indications for the use of heptral preratar. The use of this drug must be agreed with the doctor.
- Cholecystitis is chronic
- Intrahepatic cholestasis
- Cholangitis
- Toxic liver damage
- Fatty liver
- Hepatitis
- Cirrhosis
- Encephalopathy
- Withdrawal syndrome
- Depression
The drug may give a slight tonic effect, so it is not recommended to use it immediately before bedtime.
Side effects of the drug "Heptral"
The instruction contains comprehensive information about the possible side effects of the drug.
Side effects associated with the gastrointestinal tract:
- Dyspepsia
- Heartburn
- Gastralgia
In addition, side effects may occur due to intolerance to the components of the drug.
A solution for use must be prepared immediately before injection. In the event that the color of the powder is different from whitish, then it is not recommended to use it.
Contraindications
- Pregnancy
- Lactation
- Under 18 years old
If heptral is prescribed to patients with cirrhosis, they will need daily monitoring of the amount of nitrogen in the blood. In addition, with long-term therapy, monitoring of creatinine and urea is also necessary.
Overdose with Heptral
The instruction does not have information about cases of overdose with this drug.
Heptral drug interaction
The instruction does not have information about the consequences of any interactions of heptral with other drugs.