Medication "Metadoxil" application instructions refers to the category of drugs for the treatment of alcoholism. The drug has hepatoprotective properties, a membrane stabilizing effect, due to the ability to restore the ratio between unsaturated and saturated fatty acids.
The medicine is available in tablet form and in the form of an injection solution. The tool has a detoxifying effect associated with the activation of liver enzymes involved in the metabolism of ethanol. Due to this effect, the negative impact of toxins is reduced, their transport from the body is accelerated. The drug "Metadoxil" (instructions for use indicates this) reduces the somatic and mental manifestations of a hangover, shortens the period of elimination of withdrawal symptoms.
In addition, the tool has a non-specific antidepressant and anxiolytic effect, reduces the need for alcohol. Upon penetration, rapid absorption from the gastrointestinal tract occurs. The bioavailability of the drug is quite high - from 60 to 80%. With proteins in plasma, the drug binds to 50%. Metabolism is carried out in liver cells. Excreted in the urine.
Appointment
The solution and tablets "Metadoxil" are recommended for acute alcohol intoxication, withdrawal symptoms. The drug is prescribed for chronic alcoholism, as well as in the complex treatment of hepatic pathologies due to the influence of ethanol in particular.
Contraindications
The drug "Metadoxil" instructions for use does not allow for use during lactation and pregnancy, with intolerance to the substances contained in its composition. Caution in the appointment and therapy is shown with patients with Parkinson's disease in case of simultaneous administration of Levodopa (the effectiveness of the latter decreases). In the solution for injection, sodium metabisulfite is present. This component is able to provoke an attack (or its intensification) of bronchial asthma, allergic manifestations, especially in patients with a predisposition.
Adverse reactions
When treated with Metadoxil (the instructions for use contain this information), allergic manifestations are likely. In patients with bronchial asthma, bronchospasm may occur (with the introduction of a solution).
Dosing method
In case of alcoholic (acute) intoxication, the Metadoxil drug (instructions for use indicate this) is prescribed 300-600 mg intramuscularly or 300-900 mg per vein. The dosage is selected in accordance with the degree of poisoning. With complex treatment, the drug is prescribed in tablet form, 1 pc. twice a day. The medicine is drunk before meals for fifteen to thirty minutes. In some cases, the amount of Metadoxil may be increased to 3 tablets per day. The duration of treatment is at least three months. With withdrawal symptoms, 900 mg is administered intravenously once for three to seven days.
Means "Metadoxil". Price
Tablets in pharmacies can be purchased at a price of 760 p., Ampoules - from 510 p.