In the article, we consider the instructions for use and reviews for the drug "Doramycin". The medicine is an antibiotic that is part of the macrolide group. It has a bacteriostatic effect, disrupting protein synthesis inside the cell.
Structure
According to the instructions to "Doramycin", in one coated tablet contains:
- as an active ingredient spiramycin 3,000,000 IU;
- as auxiliary substances, the following substances: corn starch, croscarmellose sodium, magnesium stearate, microcrystalline cellulose;
- film coating: titanium dioxide, hydroxypropyl methyl cellulose, polyethylene glycol 4000, polyethylene glycol 6000, talc.
Characteristic
The tablets are coated with a milky white or white color. The shape is biconvex, round, on one side - DORA engraving.
Indications for use
In accordance with the instructions, "Doramycin" is used to treat infections that are caused by microorganisms that are sensitive to spiramycin:
- diagnosed tonsillopharyngitis, which is caused by streptococcus β-hemolytic group A (as an alternative to therapy with β-lactam-type antibiotics, especially if they cannot be used);
- acute sinusitis (taking into account the microbiological properties of the infection, the use of macrolides is necessary when therapy with β-lactam antibiotics is impossible);
- superinfection with acute bronchitis;
- exacerbation of chronic bronchitis;
- community-acquired pneumonia in patients without risk factors, clinical factors, severe symptoms that indicate the pneumococcal origin of the disease; if there is a suspicion of the presence of atypical pneumonia, the use of macrolides is justified regardless of the history and severity of the pathology;
- infectious skin diseases characterized by a benign nature: primary impetigo, ecthyma, impetiginization, infectious dermo-hypodermatitis (especially erysipelas), infectious pathologies of the oral cavity, erythrasma;
- genital non-gonococcal infections;
- toxoplasmosis of pregnant women;
- chemoprophylaxis of the recurrence of acute rheumatic fever in patients with allergic reactions to β-lactam antibiotics;
- prevention of meningococcal meningitis in patients with a contraindication to the use of rifampicin (for eradication in the nasopharynx of the microorganism Neisseria meningitidis, as well as for the prevention of patients after treatment and during rehabilitation, patients who have been in contact with people with sputum discharge for ten days before hospitalization).
"Doramycin" cannot be used in the treatment of meningococcal meningitis. Formal instructions for the proper use of antibacterial drugs must be followed.
This is confirmed by the instructions for use with "Doramycin".
Contraindications
The drug cannot be used:
- with excessive sensitivity to the active component and other substances in the composition;
- with severe defects in the functioning of the liver.
Combined with other drugs that cause ventricular tachycardia, such as pirouette, for example:
- class Ia antiarrhythmic drugs ("Disopyramide", "Hydroquinidine", "Quinidine");
- class III antiarrhythmic drugs (“Ibutilide”, “Dofetilide”, “Sotalol”, “Amiodarone”);
- neuroleptic benzamide group - "Sultoprid";
- other: arsenic preparations, Misolastine, Dolasetron, Difemanil for intravenous use, Levofloxacin, Vandetanib, Moxifloxacin, Hydroquinidine, Prucaloprid, Escitalopram, Toremifenone, Domorephenid, Domorephenid "," Vincamine "for intravenous use," Mehitazin "," Disopyramide "," Erythromycin "," Citalopram "," Dronedaron ".
Pregnancy and lactation
How to take "Doramycin" during pregnancy? The instruction reports that during this period it can be used according to indications. Its use must be carried out exclusively for medical purposes and strictly follow the prescribed dosage. The duration of administration and the amount of the drug are determined by the severity and type of the disease. The course of use on average ranges from a week to ten days, is prescribed 2-3 times a day for one tablet. The medicine is taken regardless of the meal, is not chewed, washed down with still water in large quantities.
When prescribing the drug during the lactation period, you need to stop breast-feeding the baby, since spiramycin can be excreted together with the woman’s milk. What else can you learn from the instructions for use with "Doramycin"?
Method of application and dosage features
Patients with normal kidney function. If the patient has renal failure, dosage adjustment will not be required. There is no experience with the use of the drug in the amount of 3,000,000 IU in pediatrics.
Doramycin is prescribed exclusively to adults per day from 6,000,000 to 9,000,000 IU, the duration is ten days.
In the treatment of tonsillitis in a dosage of 6,000,000 during the day, the duration of use is also ten days.
To prevent meningococcal meningitis - every 12 hours 3,000,000 IU for five days.
In the treatment of toxoplasmosis in women in the position: “Doramycin” is prescribed inside in an amount of 6 to 9,000,000 IU per day in the form of three-week courses with a break for two weeks, which greatly reduces the likelihood of developing a fetal infection inside the womb.
Toxoplasmosis should be treated in accordance with the instructions and medical recommendations. The therapeutic regimen for a particular patient is selected directly by a specialist.
Tablets should be drunk, not chewed and washed down with water in sufficient quantities.
According to the instructions for use, "Doramycin" for children is also suitable.
Side effects
From the gastrointestinal tract: diarrhea, abdominal pain, vomiting, nausea, in very rare cases - pseudomembranous colitis.
Epidermis: itching, urticaria, very rarely - anaphylactic shock, Quincke's edema.
Peripheral and central nervous system: transient and rare paresthesia.
Symptoms of liver damage: in very rare cases, pathogenic results of liver tests.
Hematopoietic organs: there is evidence of a rare occurrence of hemolytic anemia.
Overdose
In accordance with the instructions to "Doramycin", spiramycin has not determined its toxic dosage.
Gastrointestinal disorders can occur after using the drug in high doses.
If an overdose occurs, the QT period must be established, especially if there are other risk factors (congenital increase in the QT period, hypokalemia, the use of other drugs that extend the QT interval, or cause ventricular fibrillation-flutter).
Spiramycin lacks a specific antidote.
Symptomatic therapy is recommended.
What else does the instructions for use with the drug "Doramycin" tell us?
Interaction with various drugs
The following drug interactions require caution when applying:
- Levodopa (simultaneously with Carbidopa): the absorption of Carbidopa is inhibited with a reduced degree of Levodopa in the blood plasma;
- clinical monitoring and presumed dosage adjustment of Levodopa;
- separate problems in the international normalized ratio (imbalance of INR).
There is evidence of numerous cases of excessive activity of oral anticoagulants in people who received antibiotic therapy. The inflammatory picture or severe infection, age and condition of patients as a whole are risk factors. That is why it becomes difficult to identify the effects of infection and its treatment on the development of an imbalance of INR, but some groups of antibacterial drugs and antibiotics have a greater effect on the INR imbalance compared to others. They mainly include a number of cephalosporins, fluoroquinolones, cotrimoxazole, cyclins and macrolides. This describes the instructions for use with "Doramycin." During pregnancy, this should especially be taken into account.
special instructions
If a patient appears at the very beginning of treatment with pustular rashes and generalized erythema, accompanied by an increase in body temperature, an acute exanthematous generalized pustulosis should be suspected.
If such a reaction develops, then you need to stop using the drug in the future, both independently and along with other means. Since the active substance is not excreted by the kidneys, there is no need to adjust its quantity to patients with insufficiency of this organ.
Do not drink tablets for children under the age of six, as they may choke on them. This is indicated in the instructions for "Doramycin."
Due to the fact that there is no confirmed information about the use of the drug in patients with kidney failure, you need to be careful when prescribing it to this group of people. Since the withdrawal of the drug is carried out with urine in a small amount, only patients who have a severe form of insufficiency need to adjust the dose.
There is information about a very rare occurrence of hemolytic anemia in those people who have a deficiency of glucose-6-phosphate dehydrogenase. That is why they are not recommended to take the drug.
We reviewed the instructions for use.
Analogues of "Doramycin"
If Doramycin is not on sale, a specialist can prescribe one of its analogues, which have a similar effect on the body. Antibiotics that are allowed during pregnancy: Clarimycin, Spirex, Macromycin, Claricar, Rovamycin, Vilprafen Solutab, Rovacid, Roxithromycin, Santpiram.
Reviews
Many pregnant women respond positively to the drug, since the desired result was achieved, side effects were absent.
At the same time, there are many negative opinions about its use in such a period. Doramycin is not recommended for use even in the third trimester of pregnancy, despite the fact that at this time the drugs can harm the fetus less. Patients complain of a large number of side effects: loss of appetite, nausea, stomach pain and severe heartburn. In a couple of days - loose stools, thrush and itching in the body. In addition, the test indicators respond to the antibiotic: bilirubin growth, all the same bilirubin mark, etc. The drug did not help in any way and even harmed the patient.
Some women note that after taking Doramycin, their mouth and fingers were numb. Many patients believe that antibiotics, in principle, cannot be safe, therefore it is worth resorting to them only as a last resort.
The article provided detailed instructions for use with the tablets "Doramycin".